Bodil Steen Rasmussen
A5091025546- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- Cardiac and Coronary Surgery Techniques
- Mechanical Circulatory Support Devices
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Metabolomics and Mass Spectrometry Studies
- Thermal Regulation in Medicine
- Atrial Fibrillation Management and Outcomes
- Cardiac Valve Diseases and Treatments
- Venous Thromboembolism Diagnosis and Management
- Airway Management and Intubation Techniques
- Anesthesia and Sedative Agents
- Anesthesia and Pain Management
- Cardiac Ischemia and Reperfusion
- Education, Healthcare and Sociology Research
- Acute Kidney Injury Research
- Frailty in Older Adults
- Cardiovascular and exercise physiology
Aalborg University Hospital
2016-2025
Aalborg University
2016-2025
Centre for Research in Intensive Care
2017-2025
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2025
Western Health
2022-2025
Deakin University
2022-2025
University of Copenhagen
2018-2025
North Denmark Region
2024
Rigshospitalet
2013-2023
Zealand University Hospital
2021-2023
Blood transfusions are frequently given to patients with septic shock. However, the benefits and harms of different hemoglobin thresholds for transfusion have not been established.In this multicenter, parallel-group trial, we randomly assigned in intensive care unit (ICU) who had shock a concentration 9 g per deciliter or less receive 1 leukoreduced red cells when level was 7 (lower threshold) (higher during ICU stay. The primary outcome measure death by 90 days after randomization.We...
The effect of bystander interventions on long-term functional outcomes among survivors out-of-hospital cardiac arrest has not been extensively studied.We linked nationwide data arrests in Denmark to outcome and reported the 1-year risks anoxic brain damage or nursing home admission death from any cause patients who survived day 30 after an arrest. We analyzed according whether cardiopulmonary resuscitation (CPR) defibrillation was performed evaluated temporal changes outcomes.Among 2855 were...
Prophylaxis for gastrointestinal stress ulceration is frequently given to patients in the intensive care unit (ICU), but its risks and benefits are unclear.In this European, multicenter, parallel-group, blinded trial, we randomly assigned adults who had been admitted ICU an acute condition (i.e., unplanned admission) were at risk bleeding receive 40 mg of intravenous pantoprazole (a proton-pump inhibitor) or placebo daily during stay. The primary outcome was death by 90 days after...
Patients with acute hypoxemic respiratory failure in the intensive care unit (ICU) are treated supplemental oxygen, but benefits and harms of different oxygenation targets unclear. We hypothesized that using a lower target for partial pressure arterial oxygen (Pao2) would result mortality than higher target.
Intravenous fluids are recommended for the treatment of patients who in septic shock, but higher fluid volumes have been associated with harm intensive care unit (ICU).In this international, randomized trial, we assigned shock ICU had received at least 1 liter intravenous to receive restricted or standard therapy; were included if onset within 12 hours before screening. The primary outcome was death from any cause 90 days after randomization.We enrolled 1554 patients; 770 restrictive-fluid...
Haloperidol is frequently used to treat delirium in patients the intensive care unit (ICU), but evidence of its effect limited.
Ilofotase alfa is a human recombinant alkaline phosphatase with reno-protective effects that showed improved survival and reduced Major Adverse Kidney Events by 90 days (MAKE90) in sepsis-associated acute kidney injury (SA-AKI) patients. REVIVAL, was phase-3 trial conducted to confirm its efficacy safety. In this international double-blinded randomized-controlled trial, SA-AKI patients were enrolled < 72 h on vasopressor 24 of AKI. The primary endpoint 28-day all-cause mortality. main...
Importance Supplemental oxygen is ubiquitously used in patients with COVID-19 and severe hypoxemia, but a lower dose may be beneficial. Objective To assess the effects of targeting Pa o 2 60 mm Hg vs 90 hypoxemia intensive care unit (ICU). Design, Setting, Participants Multicenter randomized clinical trial including 726 adults receiving at least 10 L/min or mechanical ventilation 11 ICUs Europe from August 2020 to March 2023. The was prematurely stopped prior outcome assessment due slow...
OBJECTIVES: Randomized clinical trials informing practice (e.g., like large, pragmatic, and late-phase trials) should ideally mostly use harmonized outcomes that are important to patients, family members, clinicians, researchers. Core outcome sets for specific subsets of ICU patients exist, example, respiratory failure, delirium, COVID-19, but not in general. Accordingly, we aimed develop a core set adult general patients. DESIGN: We developed Denmark following the Outcome Measures...
Background— Conventional coronary artery bypass grafting performed with the use of cardiopulmonary is a well-validated treatment for patients ischemic heart disease. Off-pump (OPCAB) has been suggested to reduce number perioperative complications, especially in elderly patients. Methods and Results— In multicenter, randomized trial, we assigned 900 >70 years age conventional or OPCAB surgery. After 30 days, blinded end-point committee assessed whether combined end point death, stroke,...
Background— Data on long-term function of out-of-hospital cardiac arrest survivors are sparse. We examined return to work as a proxy preserved without major neurologic deficits in survivors. Methods and Results— In Denmark, arrests have been systematically reported the Danish Cardiac Arrest Register since 2001. During 2001–2011, we identified 4354 patients employed before among 12 332 working-age (18–65 years), whom 796 survived day 30. Among (median age, 53 years [quartile 1–3, 46–59...
Background The population is aging. We examined changes in the proportion of elderly (≥ 80 years) intensive care unit (ICU) patients during 2005–2011 and association between age mortality controlling for preexisting morbidity. Methods Through Danish National Patient Registry, we identified a cohort 49,938 ICU admissions (47,596 patients) Northern Denmark from 2005 to 2011. Patients were subdivided groups (15–49, 50–64, 65–79 ≥ calendar year. estimated 30-day 31–365-day rate ratios (MRRs),...
Norepinephrine, the first-line vasopressor for septic shock, is not always effective and has important catecholaminergic adverse effects. Selepressin, a selective vasopressin V1a receptor agonist, noncatecholaminergic that may mitigate sepsis-induced vasodilatation, vascular leakage, edema, with fewer To test whether selepressin improves outcome in shock. An adaptive phase 2b/3 randomized clinical trial comprising 2 parts included adult patients (n = 868) shock requiring more than 5 μg/min...
We compared dexamethasone 12 versus 6 mg daily for up to 10 days in patients with coronavirus disease 2019 (COVID-19) and severe hypoxaemia the international, randomised, blinded COVID STEROID 2 trial. In primary, conventional analyses, predefined statistical significance thresholds were not reached. conducted a pre-planned Bayesian analysis facilitate probabilistic interpretation. analysed outcome data within 90 intention-to-treat population (data available 967 982 patients) using models...
In surgical teams, health professionals are highly interdependent and work under time pressure. It is of particular importance that teamwork well-functioning in order to achieve quality treatment patient safety. Relational coordination, defined as "communicating relating for the purpose task integration," has been found contribute coordination also psychological safety ability learn from mistakes. Although extensive research carried out regarding relational many contexts including surgery,...
Disclaimer 2019: The EACTS/EACTA/EBCP Guidelines represent the views of EACTS, EACTA and EBCP were produced after careful consideration scientific medical knowledge evidence available at time their dating. are not responsible in event any contradiction, discrepancy and/or ambiguity between other official recommendations or guidelines issued by relevant public health authorities, particular relation to good use healthcare therapeutic strategies. Health professionals encouraged take fully into...
Previous trials have suggested that vasopressin and methylprednisolone administered during in-hospital cardiac arrest might improve outcomes.To determine whether the combination of improves return spontaneous circulation.Multicenter, randomized, double-blind, placebo-controlled trial conducted at 10 hospitals in Denmark. A total 512 adult patients with were included between October 15, 2018, January 21, 2021. The last 90-day follow-up was on April 2021.Patients randomized to receive a (n =...
Most data on intensive care unit (ICU) patients with COVID-19 originate in selected populations from stressed healthcare systems shorter term follow-up. We present characteristics, interventions and longer outcomes of the entire, unselected cohort all ICU Denmark where capacity was not exceeded.We identified SARS-CoV-2 admitted to any Danish 10 March 19 May 2020 registered demographics, chronic comorbidities, use organ support, length stay, vital status patient files. Risk factors for death...
Midline catheters (MCs) are widely used, but safety and efficacy compared with peripherally inserted central (PICCs) has not been adequately evaluated.
We assessed long-term outcomes in acutely admitted adult patients with delirium treated intensive care unit (ICU) haloperidol versus placebo.
The aims of the study were to examine prognostic value pre-operative left ventricular systolic and diastolic function on early, late mortality after valve replacement for aortic stenosis, identify possible underlying mechanisms. Ninety-one prospectively recruited consecutive patients with a mean age 61 years underwent stenosis concomitant coronary artery bypass grafting in 32 minimum postoperative observation period 5·4 years. There six early (≤30 days postoperatively) 19 deaths, 18 deaths...