Urvi Shukla
A5076710103- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Venous Thromboembolism Diagnosis and Management
- COVID-19 and healthcare impacts
- Thermal Regulation in Medicine
- Dental Research and COVID-19
- Otolaryngology and Infectious Diseases
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Healthcare cost, quality, practices
- Trauma and Emergency Care Studies
- Colorectal and Anal Carcinomas
- Healthcare Systems and Challenges
- Diversity and Career in Medicine
- Delphi Technique in Research
- Neurological and metabolic disorders
- Diabetes Management and Research
- Airway Management and Intubation Techniques
Symbiosis International University
2020-2024
Creative Commons
2023
Aditya Birla Memorial Hospital
2014-2020
We compared dexamethasone 12 versus 6 mg daily for up to 10 days in patients with coronavirus disease 2019 (COVID-19) and severe hypoxaemia the international, randomised, blinded COVID STEROID 2 trial. In primary, conventional analyses, predefined statistical significance thresholds were not reached. conducted a pre-planned Bayesian analysis facilitate probabilistic interpretation. analysed outcome data within 90 intention-to-treat population (data available 967 982 patients) using models...
We are using multimodal technique to improve hand hygiene (HH) compliance among all health care staff for the past 1-year. This cross-sectional observational study was conducted in surgical ICU assess adherence HH nurses and allied healthcare workers, at end of training year.This a direct observation technique. A single observer collected data. During this analysis, 1500 opportunities were observed. tested 5 moments as per WHO guidelines.Overall Guidelines 78%. Nurses had an rate 63%; 86.5%....
Background The coronavirus disease 2019 (COVID‐19) pandemic has resulted in millions of deaths and overburdened healthcare systems worldwide. Systemic low‐dose corticosteroids have proven clinical benefit patients with severe COVID‐19. Higher doses are used other inflammatory lung diseases may offer additional benefits At present, the balance between harms higher vs. lower for COVID‐19 is unclear. Methods COVID STEROID 2 trial an investigator‐initiated, international, parallel‐grouped,...
BACKGROUND: Optimal thromboprophylaxis for hospitalized patients with coronavirus disease 2019 (Covid-19) is uncertain. METHODS: In an open-label, adaptive platform trial, we randomly assigned adults Covid-19 to low-dose low-molecular-weight heparin or intermediate-dose plus aspirin. response external evidence, the aspirin intervention was discontinued and a therapeutic-dose arm added. The primary end point death requirement new organ support by day 28, analyzed Bayesian logistic model....
The novel coronavirus, named SARS-CoV-2, was first described in December 2019 as a cluster of pneumonia cases Wuhan, China. It has since been declared pandemic, with substantial mortality.In our case series, we describe the clinical presentation, characteristics, and outcomes initial experience managing 24 critically ill COVID-19 patients at designated ICU Western India.Median age 54 years, 58% were males. All presented moderate to severe acute respiratory distress syndrome (ARDS); however,...
Coronavirus disease 2019 (COVID-19) can lead to severe hypoxic respiratory failure and death. Corticosteroids decrease mortality in severely or critically ill patients with COVID-19. However, the optimal dose remains unresolved. The ongoing randomised COVID STEROID 2 trial investigates effects of higher vs lower doses dexamethasone (12 6 mg intravenously daily for up 10 days) 1,000 adult COVID-19 hypoxia.
Gender disparity in Critical Care Medicine (CCM) persists globally, with women being underrepresented. Female Intensivists remain a minority, facing challenges academic and leadership positions at the workplace within societies. The Indian Society of (ISCCM) recognized need for addressing issues related to gender parity constituted its first Diversity Equity Inclusion (DEI) Committee 2023. Through Delphi process involving 38 Panelists including 53% women, consensus stability were achieved 18...
Objective: To determine whether high-flow nasal oxygen (HFNO) or noninvasive ventilator (NIV) can avoid invasive mechanical ventilation (IMV) in COVID-19-related acute respiratory distress syndrome (ADRS), and the outcome predictors of these modalities.Design: Multicenter retrospective study conducted 12 ICUs Pune, India.Patients: Patients with COVID-19 pneumonia who had PaO 2 /FiO ratio <150 were treated HFNO and/or NIV.Intervention: NIV.Measurements: The primary was to assess need...
Cronkhite Canada Syndrome (CCS) is a rare syndrome, described in 1955 by Americans, Leonard Wolsey and Wilma Jeanne the New England Journal of Medicine [1]. About 450 cases have been reported. Complications, like malignant transformation, unprovoked thromboembolism known. Since there wide variability medical presentation, no definitive diagnostic treatment protocol s set. The mortality remains at 55%.We report case 50 year old male patient presenting with diarrhea, weight loss, abdominal...
In the COVID-STEROID 2 trial there was suggestion of heterogeneity treatment effects (HTE) between patients enrolled from Europe vs. India on primary outcome. Whether HTE for remaining patient-centred outcomes is unclear.
Abstract Infection with SARS-Cov-2 virus, is associated significant morbidity and mortality, in addition to the economic burden it has put on country. While waiting for a vaccine that gives adequate protection, necessary understand course of infection identify drugs could reduce its impact. The results this multicenter study involving 1035 hospitalized patients Pune, identified diabetes, hypertension low lymphocyte counts as predictors mortality. There also an indication multiple...
Abstract IMPORTANCE Dexamethasone 6 mg daily is recommended for up to 10 days in patients with severe and critical COVID-19, but a higher dose may benefit those more disease. OBJECTIVE To assess the effects of dexamethasone 12 versus COVID-19 hypoxia. DESIGN, SETTING, PARTICIPANTS We conducted parallel-grouped, stratified, blinded randomized trial including 1000 adults confirmed receiving at least l/min oxygen or mechanical ventilation 26 hospitals Europe India from August 2020 May 2021....
Abstract Acute kidney injury can complicate rhabdomyolysis in 10-40% patients. Myoglobinuria and elevated creatine kinase (CK) form the basis of diagnosis. When associated with azotemia and/or oliguria, intermittent hemodialysis is a treatment option. 31-year-old young man came lower limb pain after doing 800 sit ups. At presentation, blood pressure was high, serum creatinine 15.7mg/dl kinase(CK)>20000 IU/L. Intermittent dialysis initiated. He developed posterior reversible encephalopathy...
Abstract Background Maharashtra is one of the worst affected states in this pandemic. 2 As 30th September, has total 1.4 million cases with 38,000 deaths. Objective was to study associations severity disease and need for ICU treatment COVID-19 patients. Methods A retrospective clinical course 800 hospitalized patients, a predictive model treatment. Eight hundred consecutive patients admitted confirmed disease. Results Average age 41 years, 16% were <20 years age, 55% male, 50%...
Introduction: Understanding pulmonary function at various phases after coronavirus disease 2019 (COVID-19) infection is critical for determining the exact pathophysiological mechanism of COVID-19. Research Question: What correlation between spirometry indices and clinical indicators in COVID-19 patients over a 6-week follow-up? Objectives: 1) To assess deterioration or improvement parameters including forced vital capacity (FVC), expiratory volume one second (FEV 1 ), ratio FEV /FVC...
Abstract The disease burden of severe neurological and neurosurgical illnesses in low-income middle-income countries (LMICs) is high. Management these patients by a dedicated neurocritical care team can improve outcome. Globally, there significant variation organization, structure, outcome with illnesses. This consensus statement aims to contextualize the standards for critical units (NCCUs) LMICs. Recommendations were made about organization infrastructure, personnel, logistics, training,...
Importance: Description of the range clinical-laboratory characteristics Indian COVD-19 patients. Accurate prediction requirement for ICU treatment based on routine tests at presentation can advise policy to triage patients into appropriate facilities and save resources.Objective: To study associations severity disease need in COVID-19 patients.Design: A retrospective clinical course 800 hospitalized patients, a predictive model treatment.Setting: dedicated tertiary care hospital Pune, India...