A5068491788- Geriatric Care and Nursing Homes
- Colorectal Cancer Treatments and Studies
- Urinary Tract Infections Management
- COVID-19 Clinical Research Studies
- Antibiotic Use and Resistance
- Influenza Virus Research Studies
- Emergency and Acute Care Studies
- Patient Satisfaction in Healthcare
- Infection Control in Healthcare
- Gastric Cancer Management and Outcomes
- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- Genetic factors in colorectal cancer
- Cardiac, Anesthesia and Surgical Outcomes
- Health Policy Implementation Science
- Clinical practice guidelines implementation
- Surgical site infection prevention
- Antimicrobial Resistance in Staphylococcus
- Infective Endocarditis Diagnosis and Management
- Pressure Ulcer Prevention and Management
- Long-Term Effects of COVID-19
- Lung Cancer Treatments and Mutations
- HIV, Drug Use, Sexual Risk
- Public Health Policies and Education
- SARS-CoV-2 and COVID-19 Research
Peter Doherty Institute
2021-2025
The University of Melbourne
2022-2025
Australian Commission on Safety and Quality in Health Care
2025
Victorian Aboriginal Health Service
2022-2024
Royal Bolton Hospital
2024
Eastern Health
2012-2024
Australian Government
2024
The Royal Melbourne Hospital
2001-2024
The Coordinating Center
2024
Monash University
2018-2023
Abstract Background To prospectively evaluate the efficacy and safety of selective internal radiation (SIR) spheres in patients with inoperable liver metastases from colorectal cancer who have failed 5FU based chemotherapy. Methods Patients were enrolled at three Australian centres. All had previously received 5-FU chemotherapy for metastatic cancer. ECOG 0–2 dominant or only disease. Concurrent was given investigator discretion. Results Thirty treated between January 2002 March 2004. As...
The standard management of rectal cancer continues to be defined by the results randomized, clinical trials exploring optimal timing and use adjuvant chemotherapy radiation therapy in relation surgery. patient with who is elderly and/or has significant comorbidities refuses surgery are contexts for which there limited current data guide decision making.A retrospective analysis was performed at six Australian centers patients treated or chemoradiation alone because excessive operative risk...
Abstract Aim: To prospectively evaluate the efficacy and safety of Selective Internal Radiation (SIR) Spheres (Sirtex Medical, Sydney, NSW, Australia) in patients with unresectable primary or secondary hepatic malignancies. Methods: We report our experience SIR sphere therapy at three Australian centres. Patients previously untreated colorectal cancer (CRC) received concurrent 5FU, other CRC 5‐FU investigator discretion all spheres alone. Results: Forty‐six were enrolled between January 2002...
The frequency and type of psychiatric disease were investigated in 40 patients suffering from systemic lupus erythematosus (SLE) 27 control subjects with rheumatoid arthritis or inflammatory bowel disease. morbidity at the time interview was same two groups, but SLE had experienced more episodes illness past, psychotic symptoms occurred only this group. Half previous current evidence neurological involvement; an association found between SLE, while anxiety affective disturbances appeared to...
Abstract Background The changing treatment landscape for metastatic colorectal cancer creates multiple potential strategies. An A ustralian‐centric database capturing comprehensive information across a range of locations would create valuable resource enabling important research questions to be addressed. Aims To establish collection consensus dataset and outcomes at public private hospitals ustralia. Methods electronic was developed by panel clinicians, capture an agreed patients with newly...
Abstract Background Diabetic foot infections (DFI) present a major morbidity, mortality and economic challenge for the tertiary health sector. However, lack of high quality evidence specific treatment regimens patients with DFIs may result in inconsistent management. This study aimed to identify DFI caseload proportion patterns clinical practice Infectious Diseases (ID) Physicians Trainees within Australia New Zealand. Methods A cross‐sectional online survey Australian Zealand ID was...
BACKGROUND: Optimal thromboprophylaxis for hospitalized patients with coronavirus disease 2019 (Covid-19) is uncertain. METHODS: In an open-label, adaptive platform trial, we randomly assigned adults Covid-19 to low-dose low-molecular-weight heparin or intermediate-dose plus aspirin. response external evidence, the aspirin intervention was discontinued and a therapeutic-dose arm added. The primary end point death requirement new organ support by day 28, analyzed Bayesian logistic model....
Clear specification of desired behaviour within evidence-based guidelines and policies might make them more actionable, i.e. increase the likelihood that those behaviours will take place in practice. It was our expectation level specificity such documents would be higher, detailed, at organisational compared with national level, given local are developed for a specific setting workforce. This study aimed to compare infection prevention control (IPC) their guideline residential aged care...
Objective: To achieve sustained improvement in use of cefotaxime and ceftriaxone (CEFX) a major teaching hospital, as measured against national antibiotic guidelines. Design setting: Pre- post-intervention survey CEFX the Royal Melbourne Hospital, tertiary hospital Melbourne, Victoria. Intervention: Web-based antimicrobial approval system linked to guidelines was developed by multidisciplinary team implemented March 2001. Main outcome measures: Change rate (defined daily doses [DDDs] per...
To assess infection prevention and control programs in residential aged care facilities.
The inappropriate use of antibiotics is frequent in nursing homes (NHs) putting older adults at risk adverse events and contributing to the rise antimicrobial resistance. Urinary tract infections (UTIs) account for 30-50% antibiotic prescribing NHs, but have one highest rates use. Clinical decision support (CDS) embedded electronic can assist ensuring appropriateness. In this study, we aimed develop a CDS prototype improve UTIs NHs collaboration with an IT system provider, BESTMED. We used...
Voriconazole can prolong the QT interval contributing to life-threatening cardiac arrhythmia. Torsades de pointes is an uncommon but serious complication of voriconazole use which may be under-recognised. We present torsades in two patients with underlying haematological malignancy being treated for invasive fungal infection voriconazole. Patients receiving should screened and monitored evidence prolongation, if prolongation detected, consideration given alternative treatments or more...
Abstract Background Older people living in residential aged care facilities are at high risk of acquiring infections such as influenza, gastroenteritis, and more recently COVID-19. These a major cause morbidity mortality among this cohort. Quality infection prevention control practice is therefore imperative. Although appointment dedicated (IPC) lead every Australian facility now mandated, all working setting have role to play IPC. The COVID-19 pandemic revealed inadequacies IPC sector...
The global COVID-19 pandemic disproportionately affected certain populations and its management differed between countries. This national study describes characteristics outcomes of in patients with cancer Australia.We performed a multicentre cohort from March 2020 to April 2022. Data were analysed determine varying types changes over time. Multivariable analysis was risk factors associated oxygen requirement.620 15 hospitals had confirmed COVID-19. There 314/620 (50.6%) male patients,...
Colorectal cancer (CRC) incidence and mortality rates have been increasing among young patients (YP), for uncertain reasons. It is unclear whether YP a distinct tumor biology or merit different treatment approach to older (OP).
Background : Australia has an ageing population. Older people are more likely to be hospitalised and consume health resources. Old age is associated with the ‘;syndromes' of confusion, incontinence, immobility, falls polypharmacy. Prevalence these syndromes in Australian hospital setting not available. Aim To study prevalence evaluate routine practice care professionals teaching hospital. Methods Assessment 100 consecutive patients above 70 years 50 doctors nurses. Results The found a high...
Abstract Background Communication is pivotal to the effective care and treatment of patients in our health systems. Despite this understanding, clinicians are not sufficiently educated confidently conduct complex discussions with patients. skills workshops have been shown be an educational format improve clinician skills. However, despite increasing interprofessional focus within modern medicine, there few studies looking at communication workshops. Methods A qualitative study was conducted...
Sepsis is the world's leading cause of death and its detection from a range data coding sources, consistent with consensus clinical definition, desirable.
Immunosuppression increases the risk that parasite will disseminate, turning a mild, self-limiting disease into something much more serious