- Burn Injury Management and Outcomes
- Wound Healing and Treatments
- Antimicrobial Resistance in Staphylococcus
- Diabetic Foot Ulcer Assessment and Management
- Streptococcal Infections and Treatments
- Bacterial Identification and Susceptibility Testing
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Use and Resistance
- Gut microbiota and health
- Pressure Ulcer Prevention and Management
- Heterotopic Ossification and Related Conditions
- Autoimmune Bullous Skin Diseases
- Diagnosis and Treatment of Venous Diseases
- Metabolomics and Mass Spectrometry Studies
- Clostridium difficile and Clostridium perfringens research
- Pelvic and Acetabular Injuries
- Climate Change and Health Impacts
- Nosocomial Infections in ICU
- Traumatic Brain Injury and Neurovascular Disturbances
- Dermatology and Skin Diseases
- Antibiotic Resistance in Bacteria
- Mycobacterium research and diagnosis
- Long-Term Effects of COVID-19
- Viral Infections and Vectors
- Thermal Regulation in Medicine
Fiona Stanley Hospital
2016-2025
Pathwest Laboratory Medicine
2017-2025
The University of Western Australia
2021-2024
Fremantle Hospital
2013-2024
Fiona Stanley Fremantle Hospitals Group
2024
Government of Western Australia Department of Health
2023-2024
The Kids Research Institute Australia
2024
Imperial College London
2023
South Metropolitan Health Service
2023
Hôpital Saint-Antoine
2023
We performed quantitative metabolic phenotyping of blood plasma in parallel with cytokine/chemokine analysis from participants who were either SARS-CoV-2 (+) (n = 10) or (-) 49). positivity was associated a unique phenotype and demonstrated complex systemic response to infection, including severe perturbations amino acid kynurenine pathways. Nine metabolites elevated strongly infection (quinolinic acid, glutamic nicotinic aspartic neopterin, kynurenine, phenylalanine, 3-hydroxykynurenine,...
To investigate the systemic metabolic effects of SARS-CoV-2 infection, we analyzed 1H NMR spectroscopic data on human blood plasma and co-modeled with multiple cytokines chemokines (measured in parallel). Thus, 600 MHz solvent-suppressed single-pulse, spin-echo, 2D J-resolved spectra were collected recorded from rRT-PCR-positive patients (n = 15, sampling timepoints) age-matched healthy controls 34, confirmed rRT-PCR negative), together COVID-19/influenza-like clinical symptoms who tested...
BackgroundInterferon gamma release assays (IGRA) are replacing the tuberculin skin test (TST) as a diagnostic tool for Mycobacterium tuberculosis infection. However research into test's performance in high HIV-TB burden setting is scarce. This study aimed to define sensitivity of an IGRA, QuantiFERON-TB® Gold In-Tube (QGIT), adult Zambian patients with active smear-positive tuberculosis. Secondary outcomes focussed on effect HIV performance.Principal FindingsPatients attending government...
Dysregulated lipid metabolism underpins many chronic diseases including cardiometabolic diseases. Mass spectrometry-based lipidomics is an important tool for understanding mechanisms of dysfunction and widely applied in epidemiology clinical studies. With ever-increasing sample numbers, single batch acquisition often unfeasible, requiring advanced methods that are accurate robust to batch-to-batch interday analytical variation. Herein, optimized comprehensive targeted workflow plasma serum...
Delayed diagnosis of patients with sepsis or septic shock is associated increased mortality and morbidity. UPLC-MS NMR spectroscopy were used to measure panels lipoproteins, lipids, biogenic amines, amino acids, tryptophan pathway metabolites in blood plasma samples collected from 152 within 48 h admission into the Intensive Care Unit (ICU) where 62 had no sepsis, 71 19 shock. Patients higher concentrations neopterin lower levels HDL cholesterol phospholipid particles comparison nonsepsis...
Diabetes-related foot infections cause substantial morbidity and mortality, both globally in Australia. There is a need for up-to-date evidence-based guidelines to ensure optimal management of patients with diabetes-related infections. We aimed identify adapt high quality international the Australian context become new guideline people infection.
Abstract Background Diabetic foot infections (DFI) present a major morbidity, mortality and economic challenge for the tertiary health sector. However, lack of high quality evidence specific treatment regimens patients with DFIs may result in inconsistent management. This study aimed to identify DFI caseload proportion patterns clinical practice Infectious Diseases (ID) Physicians Trainees within Australia New Zealand. Methods A cross‐sectional online survey Australian Zealand ID was...
Pre-clinical studies suggest that non-steroidal anti-inflammatory therapy may reduce acute inflammation and modulate scar formation after burn injury. The objective of this trial was to determine if celecoxib administered soon improved quality. A single centre, parallel group, placebo-controlled, randomised, superiority trial. Adults with non-major injury were eligible for recruitment. Participants within 48 h admission received either six weeks 200 mg twice daily or identically packaged...
Abstract Objective: To investigate the use of rifampicin vials in Australian operating theaters (OT) to determine method administration and rationale for use. Methods: Retrospective (2022 2023) OT usage data 600 mg were analyzed compare trends between hospitals jurisdictions. An audit used during 2023 was conducted at a large tertiary hospital. Results: Fifty-nine 248 (24%) contributing National Antimicrobial Utilisation Surveillance Program recorded 2022 2023. Excluding with no usage,...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotronic photoelectric turbidimeter for determining hydrocyanic acid in solutionsE. T. Bartholomew and E. C. RabyCite this: Ind. Eng. Chem. Anal. Ed. 1935, 7, 1, 68–69Publication Date (Print):January 1935Publication History Published online1 May 2002Published inissue 1 January 1935https://pubs.acs.org/doi/10.1021/ac50093a032https://doi.org/10.1021/ac50093a032research-articleACS PublicationsRequest reuse permissionsArticle...
<h3>Objectives</h3> Published in vitro stability data for ceftolozane–tazobactam supports intermittent short duration infusions. This method of delivery is not feasible many outpatient antimicrobial therapy services that provide only one or two visits per day. study aimed to assess time, temperature and concentration-dependent an elastomeric infusion device continuous across clinically relevant ranges encountered therapy. <h3>Methods</h3> Ceftolozane–tazobactam was prepared achieve initial...
Globally, burns are a significant cause of injury that can substantial acute trauma as well lead to increased incidence chronic comorbidity and disease. To date, research has primarily focused on the systemic response severe injury, with little in literature reported impact nonsevere injuries (<15% total burn surface area; TBSA). elucidate metabolic consequences longitudinal plasma was collected from adults (n = 35) who presented at hospital admission, 6 week follow up. A cross-sectional...
Abstract Background A future Streptococcus pyogenes (Strep A) vaccine will ideally prevent a significant burden of lower limb cellulitis; however, natural immune responses to proposed antigens following an episode cellulitis remain uncharacterized. Methods We enrolled 63 patients with and 26 invasive beta hemolytic streptococci infection, using multiplexed assay measure immunoglobulin G against Strep candidate antigens, including: streptolysin O (SLO), deoxyribonuclease B (DNB), group...
Abstract There is an urgent need for interventions that improve healing time, prevent amputations and recurrent ulceration in patients with diabetes‐related foot wounds. In this randomised, open‐label trial, participants were randomised to receive application of non‐cultured autologous skin cells (“spray‐on” skin; ReCell) or standard care large (>6 cm 2 ), adequately vascularised The primary outcome was complete at 6 months, determined by assessors blinded the intervention. Forty‐nine...
COVID-19 is a new multi-organ disease causing considerable worldwide morbidity and mortality. While many recognized pathophysiological mechanisms are involved, their exact causal relationships remain opaque. Better understanding needed for predicting progression, targeting therapeutic approaches, improving patient outcomes. mathematical models describe epidemiology, none have described its pathophysiology.In early 2020, we began developing such models. The SARS-CoV-2 virus's rapid extensive...
"Endemic (Murine) Typhus in Returned Travelers from Asia, a Case Series: Clues to Early Diagnosis and Comparison with Dengue" published on 03 Apr 2013 by The American Society of Tropical Medicine Hygiene.
Hyperkeratotic eruptions in the flexures, especially inguinal region, often pose a diagnostic and therapeutic dilemma. Inguinal keratotic may be caused by various infections, inflammatory dermatoses, vesico-bullous nutrient deficiencies, medication allergies other miscellaneous causes such as granular parakeratosis. We hereby report four patients who presented with idiopathic hyperkeratotic erythematous migratory nature involving region occasionally showing histopathologic features of All...