A5030050612- Antibiotic Use and Resistance
- Fungal Infections and Studies
- Nail Diseases and Treatments
- Antifungal resistance and susceptibility
- Streptococcal Infections and Treatments
- Infectious Diseases and Mycology
- SARS-CoV-2 and COVID-19 Research
- Diabetic Foot Ulcer Assessment and Management
- Long-Term Effects of COVID-19
- Parasites and Host Interactions
- Pressure Ulcer Prevention and Management
- Wound Healing and Treatments
- Clostridium difficile and Clostridium perfringens research
- Pneumonia and Respiratory Infections
- COVID-19 Clinical Research Studies
- Actinomycetales infections and treatment
- Antibiotic Resistance in Bacteria
- Dermatological diseases and infestations
- Cultural Competency in Health Care
- Mycobacterium research and diagnosis
- Viral gastroenteritis research and epidemiology
- Patient Satisfaction in Healthcare
- Malaria Research and Control
- Animal Virus Infections Studies
- Women's cancer prevention and management
Northern Territory Health Services
2024
Royal Darwin Hospital
2017-2024
Menzies School of Health Research
2020-2024
Universidade da Paz
2024
Charles Darwin University
2020-2022
Royal Prince Alfred Hospital
2017
High-risk groups, including Indigenous people, are at risk of severe COVID-19. Here we found that Australian First Nations peoples elicit effective immune responses to COVID-19 BNT162b2 vaccination, neutralizing antibodies, receptor-binding domain (RBD) SARS-CoV-2 spike-specific B cells, and CD4+ CD8+ T cells. In participants, RBD IgG antibody titers were correlated with body mass index negatively age. Reduced cells follicular helper in vaccinated participants chronic conditions (diabetes,...
Patients without human immunodeficiency virus (HIV) are increasingly recognized as being at risk for cryptococcosis. Knowledge of characteristics cryptococcosis in these patients remains incomplete.We conducted a retrospective study 46 Australian and New Zealand hospitals to compare its frequency with HIV describe HIV. between January 2015 December 2019 were included.Of 475 cryptococcosis, 90% (426 475) marked predominance both Cryptococcus neoformans (88.7%) gattii cases (94.3%). Most...
Diabetes-related foot infections cause substantial morbidity and mortality, both globally in Australia. There is a need for up-to-date evidence-based guidelines to ensure optimal management of patients with diabetes-related infections. We aimed identify adapt high quality international the Australian context become new guideline people infection.
An increasing prevalence of diabetes mellitus has led to a high risk diabetic foot infections (DFI) and associated morbidity. However, little is known about the relationship between DFI mortality.To investigate mortality factors in patients with an Australian context.A prospective cohort study inpatients May 2012 October 2016 was done at Royal Darwin Hospital, tertiary referral hospital for Top End Northern Territory. Primary outcome 1-year Cox regression analysis undertaken assess...
Combination antibiotic therapy with an antitoxin agent, such as clindamycin, is included in some guidelines for severe, toxin-mediated Staphylococcus aureus infections. The evidence to support this practice currently limited vitro, animal and observational human case-series data, no previous randomized controlled trials (RCTs).This pilot RCT aimed determine the feasibility of conducting a clinical trial examine if adjunctive clindamycin standard has greater efficacy than alone S....
Invasive bacterial infections are a leading cause of death in children, primarily low- and middle-income countries (LMIC). Links between carriage antimicrobial-resistant organisms more resistant have been established; however, little has reported regarding community antibiotic-resistant such as extended-spectrum β-lactamase (ESBL)-producing Enterobacterales LMIC. The aim this study was to determine colonic ESBL-producing fluoroquinolone- aminoglycoside-resistant healthy children three...
Fungi from the order Entomophthorales are rare but well recognized cause of tropical fungal infection, typically causing subcutaneous truncal or limb lesions in immunocompetent hosts. They may also mimic malignancy by intrabdominal mass, sometimes resulting obstructive gastrointestinal renal presentations. A 4-year-old female presented with a progressively growing abdominal wall lesion over several months, developing into acute inflammation systemic symptoms. She underwent surgical...
Abstract Indigenous peoples globally are at increased risk of COVID‐19‐associated morbidity and mortality. However, data that describe immune responses to SARS‐CoV‐2 infection in populations lacking. We evaluated Australian First Nations hospitalized with COVID‐19. Our work comprehensively mapped out inflammatory, humoral adaptive following infection. Patients were recruited early the lifting strict public health measures Northern Territory, Australia, between November 2021 May 2022....
Abstract Objectives To describe antimicrobial use (AMU) in patients admitted to hospitals Timor-Leste. Methods In 2020 and 2021, we undertook prescribing point prevalence surveys across all six Timor-Leste (one national five municipal) AMU appropriateness patients. Results 2020, 291/394 (73.9%) surveyed had been prescribed antimicrobials, compared with 260/403 (64.5%) 2021 (P = 0.004). Most (309/551; 56.1%) were one antimicrobial, 179/551 (32.5%) two. The most commonly antibiotics...
Limited data exist regarding outcomes of cryptococcosis in patients without HIV with few studies having compared Cryptococcus gattii, versus C. neoformans, infection.