A5080993375- COVID-19 epidemiological studies
- Antimicrobial Resistance in Staphylococcus
- SARS-CoV-2 and COVID-19 Research
- Antibiotics Pharmacokinetics and Efficacy
- Viral Infections and Outbreaks Research
- COVID-19 and Mental Health
- Antibiotic Use and Resistance
- SARS-CoV-2 detection and testing
- Malaria Research and Control
- COVID-19 Clinical Research Studies
- Vaccine Coverage and Hesitancy
- Zoonotic diseases and public health
- Acute Kidney Injury Research
- HIV/AIDS Impact and Responses
- Food Security and Health in Diverse Populations
- Dental Research and COVID-19
- COVID-19 diagnosis using AI
- Infection Control and Ventilation
- Bacterial Identification and Susceptibility Testing
- Hemoglobinopathies and Related Disorders
- Neonatal Health and Biochemistry
- Streptococcal Infections and Treatments
- Clostridium difficile and Clostridium perfringens research
- Nephrotoxicity and Medicinal Plants
- Otolaryngology and Infectious Diseases
The University of Melbourne
2020-2024
Peter Doherty Institute
2020-2024
The Royal Melbourne Hospital
2020-2023
Victorian Infectious Diseases Reference Laboratory
2020-2021
University of British Columbia
2012
<h3>Importance</h3> Methicillin-resistant<i>Staphylococcus aureus</i>(MRSA) bacteremia is associated with mortality of more than 20%. Combining standard therapy a β-lactam antibiotic has been reduced mortality, although adequately powered randomized clinical trials this intervention have not conducted. <h3>Objective</h3> To determine whether combining an antistaphylococcal effective alone in patients MRSA bacteremia. <h3>Design, Setting, and Participants</h3> Open-label, trial conducted at...
Abstract Introduction Classification of patients with Staphylococcus aureus bacteremia as complicated versus uncomplicated is based on a combination clinical and microbiologic variables. Whether daily body temperature common laboratory tests such C-reactive protein (CRP) white blood cell (WBC) can improve risk stratification algorithms unclear. Methods We conducted post hoc secondary analysis the CAMERA2 trial, which enrolled hospitalized adult methicillin-resistant S prospectively collected...
Abstract Distinct bacterial trophic networks exist in the gut microbiota of individuals industrialized and non-industrialized countries. In particular, microbiomes tend to be enriched with Prevotella species. To study development these -rich compositions, we investigated children aged between 7 37 months living rural Gambia (616 children, 1,389 stool samples, stratified by 3-month age groups). These infants, who typically eat a high-fibre, low-protein diet, were part double-blind, randomized...
Population Data BC (PopData) is an innovative leader in facilitating access to linked data for population health research. Researchers from academic institutions across Canada work with PopData submit requests projects involving administrative data, or without their own researcher-collected data. and its predecessor-the British Columbia Linked Health Database-have facilitated over 350 research analyzing a broad spectrum of issues. embeds privacy every aspect operations. This case study...
Abstract Among patients with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia from a prospective randomized clinical trial, acute kidney injury (AKI) rates increased increasing vancomycin exposure, even within the therapeutic range. AKI was independently more common for (flu)cloxacillin group. Day 2 AUC ≥470 mg·h/L significantly associated AKI, independent of receipt.
Background In 2017, an estimated 14 million cases of Plasmodium vivax malaria were reported from Asia, Central and South America, the Horn Africa. The clinical burden is largely driven by its ability to form dormant liver stages (hypnozoites) that can reactivate cause recurrent episodes malaria. Elimination both blood parasites (“radical cure”) required achieve a sustained response prevent ongoing transmission parasite. Novel treatment options point-of-care diagnostics are now available...
Desirability of outcome ranking (DOOR) is an emerging approach to clinical trial measurement using ordinal scale incorporate efficacy and safety endpoints. We applied a previously validated DOOR endpoint cohort CAMERA2 participants with methicillin-resistant Staphylococcus aureus bacteremia (MRSAB). Participants were randomly assigned standard therapy, or therapy plus antistaphylococcal β-lactam (combination therapy). Each participant was category, within which they further ranked according...
Combination antibiotic therapy with an antitoxin agent, such as clindamycin, is included in some guidelines for severe, toxin-mediated Staphylococcus aureus infections. The evidence to support this practice currently limited vitro, animal and observational human case-series data, no previous randomized controlled trials (RCTs).This pilot RCT aimed determine the feasibility of conducting a clinical trial examine if adjunctive clindamycin standard has greater efficacy than alone S....
Whole genome sequencing (WGS) is increasingly used by tuberculosis (TB) programs to monitor
The World Health Organization recommends that primaquine should be given once weekly for 8-weeks to patients with Plasmodium vivax malaria and glucose-6-phosphate dehydrogenase (G6PD) deficiency, but data on its antirelapse efficacy safety are limited.Within the context of a multicentre, randomised clinical trial two regimens in P. malaria, G6PD deficiency were excluded enrolled into separate 12-month observational study. They treated dose 0.75 mg/kg 8 weeks (PQ8W) plus dihydroartemisinin...
Participation of people from culturally and linguistically diverse (CALD) communities in public health research is often limited by challenges with recruitment, retention second-language data collection. Consequently, CALD are at risk their needs being marginalised interventions. This paper presents intrinsic case analyses two studies which were adapted to increase the cultural competence processes. Both cases part Optimise study, a major mixed methods study Australia provided evidence...
Longitudinal studies can provide timely and accurate information to evaluate inform COVID-19 control mitigation strategies future pandemic preparedness. The Optimise Study is a multidisciplinary research platform established in the Australian state of Victoria September 2020 collect epidemiological, social, psychological behavioural data from priority populations. It aims understand changing public attitudes, behaviours experiences epidemic modelling support responsive government policy....
Clinical risk factors for nephrotoxicity in Staphylococcus aureus bacteraemia remain largely undetermined, despite its common occurrence and clinical significance. In an international, multicentre, prospective trial (CAMERA2), which compared standard therapy (vancomycin monotherapy) to combination (adding anti-staphylococcal beta-lactam) methicillin-resistant S. bacteraemia, significantly more people the arm experienced acute kidney injury with those monotherapy (23% vs 6%).The aim of this...
ABSTRACT NaHCO 3 responsiveness is a novel phenotype where some methicillin-resistant Staphylococcus aureus (MRSA) isolates exhibit significantly lower minimal inhibitory concentrations (MIC) to oxacillin and/or cefazolin in the presence of . correlated with treatment response β-lactams an endocarditis animal model. We investigated whether -responsive strains was associated faster clearance bacteremia. The CAMERA2 trial (Combination Antibiotics for Methicillin-Resistant ) randomly assigned...
Objective To compare the concordance and acceptability of saliva testing with standard-of-care oropharyngeal bilateral deep nasal swab for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in children general practice. Design Prospective multicentre diagnostic validation study. Setting Royal Children's Hospital, two practices (cohealth, West Melbourne; Cirqit Health, Altona North) Melbourne, July–October 2020. Participants 1050 people who provided paired oropharyngeal-nasal swabs...
First Few "X" (FFX) studies provide a platform to collect the required epidemiological, clinical and virological data help address emerging information needs about COVID-19 pandemic.
Abstract Background The first few ‘X’ (FFX) studies provide evidence to guide public health decision‐making and resource allocation. adapted WHO Unity FFX protocol for COVID‐19 was implemented gain an understanding of the clinical, epidemiological, virological household transmission dynamics cases infection detected in Juba, South Sudan. Methods Laboratory‐confirmed were identified through national surveillance system, initial visit conducted with eligible identify all close contacts....