Gaëtan Plantefève
A5029943377- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Nosocomial Infections in ICU
- COVID-19 and healthcare impacts
- Cardiac Arrest and Resuscitation
- Pneumonia and Respiratory Infections
- Family and Patient Care in Intensive Care Units
- Clinical Nutrition and Gastroenterology
- SARS-CoV-2 and COVID-19 Research
- Nutrition and Health in Aging
- Frailty in Older Adults
- Hemodynamic Monitoring and Therapy
- Abdominal Surgery and Complications
- Appendicitis Diagnosis and Management
- Muscle and Compartmental Disorders
- Airway Management and Intubation Techniques
- Thermal Regulation in Medicine
- Cardiac, Anesthesia and Surgical Outcomes
- Emergency and Acute Care Studies
- Non-Invasive Vital Sign Monitoring
- Healthcare Decision-Making and Restraints
- COVID-19 Impact on Reproduction
Centre Hospitalier Victor Dupouy
2015-2025
Assistance Publique – Hôpitaux de Paris
2005-2024
Hôpital Saint-Louis
2024
Inserm
1999-2023
Université de Strasbourg
2023
Research Network (United States)
2023
French Clinical Research Infrastructure Network
2023
Université de Tours
2014-2023
Université de Bourgogne
2023
Klinikum rechts der Isar
2023
Moderate therapeutic hypothermia is currently recommended to improve neurologic outcomes in adults with persistent coma after resuscitated out-of-hospital cardiac arrest. However, the effectiveness of moderate patients nonshockable rhythms (asystole or pulseless electrical activity) debated.
Coronavirus disease 2019 (COVID-19) is associated with severe lung damage. Corticosteroids are a possible therapeutic option.
Data on the prevalence of bacterial and viral co-infections among patients admitted to ICU for acute respiratory failure related SARS-CoV-2 pneumonia are lacking. We aimed assess rate co-infections, as well report most common micro-organisms involved in severe pneumonia.In this monocenter retrospective study, we reviewed all microbiological investigations performed within first 48 h admission COVID-19 (RT-PCR positive SARS-CoV-2) failure.From March 13th April 16th 2020, a total 92 adult...
Whether the antiinflammatory and immunomodulatory effects of glucocorticoids may decrease mortality among patients with severe community-acquired pneumonia is unclear.In this phase 3, multicenter, double-blind, randomized, controlled trial, we assigned adults who had been admitted to intensive care unit (ICU) for receive intravenous hydrocortisone (200 mg daily either 4 or 7 days as determined by clinical improvement, followed tapering a total 8 14 days) placebo. All received standard...
Rationale: Most vascular catheter-related infections (CRIs) occur extraluminally in patients the intensive care unit (ICU). Chlorhexidine-impregnated and strongly adherent dressings may decrease catheter colonization CRI rates.Objectives: To determine if chlorhexidine-impregnated rates.Methods: In a 2:1:1 assessor-masked randomized trial with catheters inserted for an expected duration of 48 hours or more 12 French ICUs, we compared chlorhexidine dressings, highly adhesive standard from May...
Reignier, Jean*†; Mercier, Emmanuelle‡; Le Gouge, Amelie§; Boulain, Thierry║; Desachy, Arnaud¶; Bellec, Frederic#; Clavel, Marc**; Frat, Jean-Pierre††; Plantefeve, Gaetan‡‡; Quenot, Jean-Pierre§§; Lascarrou, Jean-Baptiste* For the Clinical Research in Intensive Care and Sepsis Group Author Information
Patients who are treated with targeted temperature management after out-of-hospital cardiac arrest shockable rhythm at increased risk for ventilator-associated pneumonia. The benefit of preventive short-term antibiotic therapy has not been shown.
Pregnant women may be at higher risk of severe complications associated with the acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which lead to obstetrical complications. We performed a case control study comparing pregnant disease 19 (cases) milder form (controls) enrolled in COVI-Preg international registry cohort between March 24 and July 26, 2020. Risk factors for severity, immediate neonatal outcomes were assessed. A total 926 positive test SARS-CoV-2 included, among 92 (9.9%)...
Abstract Background Severe acute respiratory syndrome coronavirus-2 (SARS–CoV-2)-induced distress (ARDS) causes high mortality. Umbilical cord-derived mesenchymal stromal cells (UC-MSCs) have potentially relevant immune-modulatory properties, whose place in ARDS treatment is not established. This phase 2b trial was undertaken to assess the efficacy of UC-MSCs patients with SARS–CoV-2-induced ARDS. Methods multicentre, double-blind, randomized, placebo-controlled (STROMA–CoV-2) recruited...
BackgroundWhether preventive inhaled antibiotics may reduce the incidence of ventilator-associated pneumonia is unclear.MethodsIn this investigator-initiated, multicenter, double-blind, randomized, controlled, superiority trial, we assigned critically ill adults who had been undergoing invasive mechanical ventilation for at least 72 hours to receive amikacin a dose 20 mg per kilogram ideal body weight once daily or placebo 3 days. The primary outcome was first episode during 28 days...
Ilofotase alfa is a human recombinant alkaline phosphatase with reno-protective effects that showed improved survival and reduced Major Adverse Kidney Events by 90 days (MAKE90) in sepsis-associated acute kidney injury (SA-AKI) patients. REVIVAL, was phase-3 trial conducted to confirm its efficacy safety. In this international double-blinded randomized-controlled trial, SA-AKI patients were enrolled < 72 h on vasopressor 24 of AKI. The primary endpoint 28-day all-cause mortality. main...
Objective Few outcome data are available about posterior reversible encephalopathy syndrome (PRES). We studied 90-day functional outcomes and their determinants in patients with severe PRES. Design 70 PRES admitted to 24 ICUs 2001–2010 were included a retrospective cohort study. The main measure was Glasgow Outcome Scale (GOS) of 5 (good recovery) on day 90. Main Results Consciousness impairment the most common clinical sign, occurring 66 (94%) patients. Clinical seizures occurred 57 (81%)...
Patients liberated from invasive mechanical ventilation are at risk of extubation failure, including inability to breathe without a tracheal tube (airway failure) or (non-airway failure). We sought identify respective factors for airway failure and non-airway following extubation.The primary endpoint this prospective, observational, multicenter study in 26 intensive care units was defined as need reintubation within 48 h extubation. A multinomial logistic regression model used...
Patients with SARS-CoV-2 infection are at higher risk for ventilator-associated pneumonia (VAP). No study has evaluated the relationship between VAP and mortality in this population, or compared patients other populations. The main objective of our was to determine patients.Planned ancillary analysis a multicenter retrospective European cohort. diagnosed using clinical, radiological quantitative microbiological criteria. Univariable multivariable marginal Cox's regression models,...
Anti-synthetase (AS) and dermato-pulmonary associated with anti-MDA-5 antibodies (aMDA-5) syndromes are near one of the other autoimmune inflammatory myopathies potentially responsible for severe acute interstitial lung disease. We undertook a 13-year retrospective multicenter study in 35 French ICUs order to describe clinical presentation outcome patients admitted ICU respiratory failure (ARF) revealing AS or aMDA-5 syndromes.From 2005 2017, 47 (23 males; median age 60 [1st-3rd quartiles...
Rationale: Early empirical antimicrobial treatment is frequently prescribed to critically ill patients with coronavirus disease (COVID-19) based on Surviving Sepsis Campaign guidelines.Objectives: We aimed determine the prevalence of early bacterial identification in intubated severe acute respiratory syndrome 2 (SARS-CoV-2) pneumonia, as compared influenza and characterize its microbiology impact outcomes.Methods: A multicenter retrospective European cohort was performed 36 ICUs. All adult...
Abstract Background Ventilator-associated pneumonia caused by Pseudomonas aeruginosa (PA) in hospitalised patients is associated with high mortality. The effectiveness of the bivalent, bispecific mAb MEDI3902 (gremubamab) preventing PA nosocomial was assessed PA-colonised mechanically ventilated subjects. Methods EVADE (NCT02696902) a phase 2, randomised, parallel-group, double-blind, placebo-controlled study Europe, Turkey, Israel, and USA. Subjects ≥ 18 years old, ventilated, tracheally...