A5002373578- Cytomegalovirus and herpesvirus research
- Fetal and Pediatric Neurological Disorders
- Parvovirus B19 Infection Studies
- COVID-19 Impact on Reproduction
- Pregnancy and preeclampsia studies
- COVID-19 and healthcare impacts
- Prenatal Screening and Diagnostics
- Maternal and fetal healthcare
- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Diabetes Management and Research
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Neonatal Health and Biochemistry
- Assisted Reproductive Technology and Twin Pregnancy
- Pregnancy and Medication Impact
- Gestational Diabetes Research and Management
Hospital Clínic de Barcelona
2025
Hospital Sant Joan de Déu Barcelona
2020-2023
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2022-2023
Universitat de Barcelona
2021-2023
Pregnant women may be at higher risk of severe complications associated with the acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which lead to obstetrical complications. We performed a case control study comparing pregnant disease 19 (cases) milder form (controls) enrolled in COVI-Preg international registry cohort between March 24 and July 26, 2020. Risk factors for severity, immediate neonatal outcomes were assessed. A total 926 positive test SARS-CoV-2 included, among 92 (9.9%)...
Introduction Congenital cytomegalovirus (cCMV) is the main infectious cause of sensorineural hearing loss and neurodevelopmental disability. First-trimester periconceptional period are most vulnerable times for fetal injury. Universal serological (CMV) screening in pregnant women not currently recommended. After a recent randomized controlled clinical trial that demonstrated 70% reduction vertical transmission with high-dose valacyclovir (VCV), pilot first-trimester program was launched at...
Cytomegalovirus (CMV) is a major cause of childhood disabilities, and consensus recommendations emphasize the importance hygienic measures to reduce perinatal infection. Our study aimed evaluate level awareness about CMV among health professionals pregnant women.We submitted 20-item online survey regarding infection all obstetricians midwives in Catalonia (Spain) 7-item lay version questionnaire 700 women. Levels knowledge were compared groups.Of 1,449 approached, 338 surveys answered. 72%...
To evaluate the correlation of periventricular echogenic halo (halo sign) with histopathological findings and its association other brain imaging abnormalities in fetuses cytomegalovirus (CMV) infection.
To assess fetal liver volume (FLV) by magnetic resonance imaging (MRI) in cytomegalovirus (CMV)-infected fetuses compared to a group of healthy fetuses.Most infected cases were diagnosed the evidence ultrasound abnormalities during routine scans and some after maternal CMV screening. CMV-infected considered severely or mildly affected according prenatal brain lesions identified (US)/MRI. We assessed FLV, FLV abdominal circumference (AC) ratio (FLV/AC-ratio), body (FBV) (FLV/FBV-ratio). As...
To assess maternal and perinatal outcome in women with COVID-19 during pregnancy. Multicentric prospective cohort study including singleton pregnant SARS-CoV-2 infection at 5 hospitals Spain, from April 2020 to 2021. Maternal was confirmed by clinical symptoms, nasopharyngeal PCR, or serologic test. Pregnancy follow-up performed until delivery outcomes were assessed. Cases divided into groups according the NIH classification for severity of disease. A total 415 included. asymptomatic 116...
To assess by magnetic resonance imaging (MRI) the cortical maturation pattern in fetuses with cytomegalovirus (CMV) infection mild or no abnormalities on ultrasound (US) and MRI, to establish possible differences compared healthy controls.
Although there is no evidence of vertical transmission COVID-19, fetal consequences maternal COVID-19 remain unknown. The objective the present study to assess impact during pregnancy in terms adverse perinatal outcomes, intrauterine growth restriction, cardiac or neurosonographic abnormalities, and identify association with severity disease gestational age at infection. Multicentric prospective cohort including singleton pregnant women diagnosis SARS-CoV2 infection 5 hospitals Spain,...
To evaluate the risk of neonatal respiratory morbidity (NRM) assessed by QuantusFLM® in fetuses twin and singleton pregnancies. Prospective study pregnancies from 26.0 to 38.6 weeks gestation, for which ultrasound images an axial section fetal thorax were obtained. Images collected stored original DICOM format analysed with QuantusFLM®. We included 212 (98 114 singleton), 450 classified three groups gestational age (table a). group-1 (149 images); group-2 (161 images) group-3 (140 images)....
To evaluate the agreement on risk of neonatal respiratory morbidity (NRM) in fetuses twin pregnancies. Prospective study pregnancies from 26 to 37.6 weeks gestation, for which ultrasound images an axial section fetal thorax (figure 1) were obtained. Images collected and stored DICOM format analysed with QuantusFLM®. We included 98 (20 MC 78 DC). A total 306 classified three groups gestational ages (table 1). The mean age birthweight was 37.1 (1.4); 2,435 (345)g 1 2,363 (440)g 2. There is...
Assess cortical maturation by MRI in CMV infected fetuses and establish differences compared to a group of healthy fetuses. Controls n = 24 cCMV Retrospective study including cases confirmed fetal infection control In all cases, T2-weighted-MR images obtained for clinical purposes were evaluated. The brain abnormalities established through ultrasound/MRI. Cortical development was assessed measuring sulci depth applying score according Pistorious et al. We included CMV-infected (7 unaffected...
Periventricular hyperechogenicity “halo” sign, is one of the most frequent US abnormalities in CMV-infected fetuses. It has been defined as a sign ventriculitis and white matter injury. However, there are few reports about postmortem targeted histological examination. Our objective was to obtain more information its significance prognostic value. Two experienced pathologists reviewed slides central nervous system (CNS) from 26 fetuses following termination pregnancy 2nd (N=19) or 3rd...
In a previous study, we observed that increased gamma-glutamyl transpeptidase (GGT)-levels, an enzyme with activity in kidney, pancreas, and brain, was related to severe-brain-damage (SBD) CMV-infected fetuses. However, its clinical significance uninfected fetuses is unknown. We aimed evaluate the association of GGT-levels severe brain damage CMV infected were analysed cord blood samples in: i) consecutive cases confirmed CMV-infection; ii) cohort ones neurological, cardiac, or other...