A5080712881- Congenital Diaphragmatic Hernia Studies
- Neonatal Respiratory Health Research
- Congenital Anomalies and Fetal Surgery
- Pregnancy and preeclampsia studies
- Hernia repair and management
- Prenatal Screening and Diagnostics
- Birth, Development, and Health
- Congenital Heart Disease Studies
- Fetal and Pediatric Neurological Disorders
- COVID-19 Impact on Reproduction
- Gestational Diabetes Research and Management
- Assisted Reproductive Technology and Twin Pregnancy
- Respiratory Support and Mechanisms
- Pregnancy-related medical research
- Urological Disorders and Treatments
- Spinal Dysraphism and Malformations
- Preterm Birth and Chorioamnionitis
- Tracheal and airway disorders
- COVID-19 and healthcare impacts
- Neonatal and fetal brain pathology
- Esophageal and GI Pathology
- Maternal and Perinatal Health Interventions
- Ultrasound in Clinical Applications
- Peroxisome Proliferator-Activated Receptors
- Neuroscience of respiration and sleep
KU Leuven
2016-2025
Universitair Ziekenhuis Leuven
2010-2024
University of Trieste
2023
IRCCS Materno Infantile Burlo Garofolo
2023
Organ Recovery Systems (Belgium)
2013-2018
Leipzig University
2006-2016
IFB Adiposity Diseases
2011-2016
University Hospital Leipzig
2013-2014
Beijing Obstetrics and Gynecology Hospital
2014
Hôpital Universitaire Dupuytren
2011
Pregnant women may be at higher risk of severe complications associated with the acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which lead to obstetrical complications. We performed a case control study comparing pregnant disease 19 (cases) milder form (controls) enrolled in COVI-Preg international registry cohort between March 24 and July 26, 2020. Risk factors for severity, immediate neonatal outcomes were assessed. A total 926 positive test SARS-CoV-2 included, among 92 (9.9%)...
Objective To report a recent update on fetuses with right‐sided congenital diaphragmatic hernia ( RCDH ) in the era of fetal surgery. Design Retrospective review prospectively collected data. Setting Fetal treatment centres Leuven and Barcelona. Population Consecutive cases between 2002 2012. Methods Data prenatal imaging, genetic testing, pregnancy neonatal outcomes were extracted from our databases, including structural anomalies, candidate outcome predictors such as lung size, liver...
ABSTRACT Objectives To explore the association between fetal umbilical and middle cerebral artery (MCA) Doppler abnormalities outcome in late preterm pregnancies at risk of growth restriction. Methods This was a prospective cohort study singleton restriction 32 + 0 to 36 6 weeks gestation, enrolled 33 European centers 2017 2018, which MCA velocimetry performed. Pregnancies were considered if they had estimated weight and/or abdominal circumference (AC) < 10 th percentile, abnormal...
<b><i>Background:</i></b> Caffeine is a commonly used drug for apnea of prematurity. It may, however, also have beneficial effect on bronchopulmonary dysplasia (BPD), which the most common complication extreme preterm birth. <b><i>Objectives:</i></b> To study inflammatory, structural and functional effects caffeine in an animal model BPD. <b><i>Methods:</i></b> Preterm New Zealand-Dendermonde rabbits (gestational day 28;...
Abstract Objective To investigate differences in fetal vertebroplacental ratio (VPR) depending on the occurrence of operative delivery for suspected compromise (ODFC) and composite perinatal outcome (CPO) at delivery. Methods This was a prospective observational cohort study conducted Department Obstetrics Gynecology University Hospitals Leuven, Belgium, between December 2022 April 2024. Women with term (37–42 gestational weeks) singleton pregnancy an appropriate‐for‐gestational‐age (AGA)...
Objectives To investigate the efficacy of collagen plugs at reducing risk preterm premature rupture membranes (PPROM) after fetoscopic surgery for congenital diaphragmatic hernia (CDH). Methods This was a single-center cohort study on all consecutive cases undergoing endoluminal tracheal occlusion (FETO) severe or moderate CDH, between April 2002 and May 2011 (n = 141). Cases either received plug sealing fetal membrane defect FETO did not, depending operating surgeon. The principal outcome...
The objective of this study was to document early neonatal (7 days) pulmonary outcome in the rabbit model for preterm birth and hyperoxia-induced lung injury. Preterm pups were delivered at 28 days (term = 31 days; saccular phase development) by cesarean section, housed an incubator, gavage fed 7 days. Pups divided into following groups: 1) normoxia (21% O2; group) 2) hyperoxia (>95% group). Controls born term who normoxic conditions (control Outcome measures survival, function tests using...
Bronchopulmonary dysplasia (BPD) is caused by preterm neonatal lung injury and results in oxygen dependency pulmonary hypertension. Current clinical management fails to reduce the incidence of BPD, which calls for novel therapies. Fetal rabbits have a development that mimics humans can be used as translational model test treatment options. In rabbits, exposure hyperoxia leads parenchymal changes, yet vascular damage has not been studied this model. study we document early functional...
<b><i>Introduction:</i></b> We review the characteristics and prenatal choices of patients recently evaluated for neural tube defects (NTD) at two tertiary units. The diagnosis NTD allows parents to consider all options. In selected cases spina bifida aperta this also includes fetal surgery, which we started offering after combined ‘in-house' ‘exported' training. <b><i>Material Methods:</i></b> This is a retrospective prospectively collected...
What's already known about this topic? There is increasing evidence that cell therapy using mesenchymal stem cells could have a beneficial effect in treating adult lung disease. Amniotic fluid are population of with multipotent differentiation capacities. Initial reports rodent CDH models shown promising these to improve pulmonary development utero . What does study add? Intra‐tracheal amniotic combination tracheal occlusion rabbit model increases the number alveoli, without major signs toxicity.
Following the detection of fetal growth restriction, there is no consensus about criteria that should trigger delivery in late preterm period. The consequences inappropriate early or are potentially important yet practice varies widely around world, with abnormal findings from heart rate monitoring invariably leading to delivery. Indices derived cerebral Doppler examination may guide such decisions although few studies this area. We propose a randomised, controlled trial establish optimum...
Objective To investigate whether knowledge of fetal outcome influences retrospective interpretation cardiotocographic tracings and subsequent management recommendations. Design Prospective online study. Setting Seven university hospitals in five European countries. Population Forty‐two intrapartum from women with singleton pregnancies uneventful antepartum courses. Methods Using an questionnaire, 123 healthcare professionals interpreted 42 without any provided recommendations according to...
To establish gestational age-specific reference ranges for amniotic fluid measurements in monochorionic diamniotic twin pregnancies, to compare them with previously reported singleton and examine the rationale using a age-dependent cut-off define polyhydramnios twin-twin transfusion syndrome, as is practice most European centers.We retrospectively evaluated volume 32 pregnancies that were followed longitudinally at 2-week intervals from first trimester until birth. Amniotic was assessed by...
Criteria for diagnosis of fetal growth restriction differ widely according to national and international guidelines, further heterogeneity arises from the use different biometric Doppler reference charts, making highly variable.