A5023636350- Neonatal Respiratory Health Research
- Infant Development and Preterm Care
- Neonatal and fetal brain pathology
- Birth, Development, and Health
- Neuroscience of respiration and sleep
- Neonatal Health and Biochemistry
- Pregnancy and preeclampsia studies
- Fetal and Pediatric Neurological Disorders
- Congenital Diaphragmatic Hernia Studies
- Preterm Birth and Chorioamnionitis
- Breastfeeding Practices and Influences
- Maternal Mental Health During Pregnancy and Postpartum
- Cytomegalovirus and herpesvirus research
- Child and Adolescent Psychosocial and Emotional Development
- Infant Nutrition and Health
- Prenatal Screening and Diagnostics
- Congenital Heart Disease Studies
- Gestational Diabetes Research and Management
- Assisted Reproductive Technology and Twin Pregnancy
- Infant Health and Development
- Parvovirus B19 Infection Studies
- Maternal and Perinatal Health Interventions
- Congenital Anomalies and Fetal Surgery
- Respiratory Support and Mechanisms
- Child and Adolescent Health
Universitat de Barcelona
2008-2020
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2001-2020
Hospital Clínic de Barcelona
2008-2020
Hospital Sant Joan de Déu Barcelona
2014-2017
Centre for Biomedical Network Research on Rare Diseases
2009-2017
Comilla University
2017
Sociedad Española de Nefrología
2007-2015
Weatherford College
1998-2012
Hospital Universitari de Vic
2007
Vall d'Hebron Hospital Universitari
2003
Perinatal mortality and morbidity is markedly increased in intrauterine growth restricted (IUGR) fetuses. Prenatal identification of IUGR the first step clinical management. For that purpose a uniform definition criteria are required. The etiology multifactorial whenever possible it should be assessed. When cause placental origin, to identify affected major complication chronic fetal hypoxemia. By monitoring changes vital functions thus improve both management outcome. timing delivery...
The terms early- and late-onset fetal growth restriction (FGR) are commonly used to distinguish two phenotypes characterized by differences in onset, fetoplacental Doppler, association with preeclampsia (PE) severity. We evaluated the optimal gestational age (GA) cut-off maximizing among these forms.A cohort of 656 consecutive singleton pregnancies FGR was created. decision tree analysis evaluate GA that best discriminated perinatal mortality, PE adverse outcome (fetal demise, early neonatal...
To evaluate the risk of adverse perinatal outcome according to estimated fetal weight (EFW) in a cohort term small-for-gestational-age (SGA) pregnancies with normal umbilical, middle cerebral and maternal uterine artery Doppler indices.A 132 SGA fetuses umbilical pulsatility index (PI), mean PI cerebroplacental ratio was compared control group appropriate-for-gestational-age babies, matched by gestational age at delivery. The capacity EFW percentile predict Cesarean delivery, delivery for...
Abstract Objective To evaluate the neurobehavioral outcomes of preterm infants with intrauterine growth restriction (IUGR), and without prenatal advanced brain‐sparing. Methods A cohort IUGR (birth weight < 10 th percentile abnormal umbilical artery Doppler) born before 34 weeks gestation was compared a control group appropriate‐for‐gestational age matched for gestational at delivery. MCA pulsatility index determined in all cases within 72 hours Neonatal neurobehavior evaluated 40 weeks'...
To investigate whether preterm children with low risk for neurodevelopmental deficits show long-term changes in gray matter (GM) and white (WM) volumes compared term to relate these cognitive outcome.MRI was used evaluate 20 who were determined be at born between 30 34 weeks' gestational age without major neonatal morbidity or cerebral pathology the period 22 matched, control subjects. Volumetric images analyzed by means of voxel-based morphometry identify regional alterations. Children also...
ABSTRACT Objective To evaluate the 2‐year neurodevelopmental outcome of full‐term, small‐for‐gestational‐age ( SGA ) newborns with normal placental function, according to current criteria based on umbilical artery Doppler findings. Methods A cohort consecutive prenatal was compared a group appropriate‐for‐gestational‐age AGA infants sampled from our general neonatal population. Neurodevelopmental evaluated at 24 months' corrected age using Bayley Scales Infant and Toddler Development, 3 rd...
The goal was to evaluate the neurobehavioral outcomes of term, small-for-gestational age (SGA) newborns with normal placental function.A cohort consecutive term SGA prenatal umbilical artery Doppler ultrasound findings created and compared a group infants size appropriate for gestational age, who were sampled from our general neonatal population. Neonatal behavior evaluated at corrected 40 +/- 1 weeks Behavioral Assessment Scale. effect study on each Scale area adjusted, through multivariate...
Abstract There is increasing evidence about the presence of white matter damage in subjects with a history premature birth, even those classified as good outcome because an apparently normal development. Although intellectual performance within limits children it significantly decreased compared to paired controls. The purpose this study was investigate relationship between lower intelligence quotient and preterm adolescents. sample comprised 44 adolescents (mean age ± S.D.: 14.4 1.6 years)...
Abstract Congenital cytomegalovirus (CMV) infection occurs in 0.6–0.7% of all newborns and is the most prevalent infection-related cause congenital neurological handicap. Vertical transmission around 30% cases, but fetus not always affected. Symptomatic at birth have a much higher risk suffering severe sequelae. Detection specific IgG IgM avidity seem to be reliable tests identify primary interpretation clinical context may difficult. If seroconversion documented or fetal suspected by...
To evaluate bone mineral density (BMD) in preterm neonates at discharge and identify the optimum cutoff values for serum alkaline phosphatase (ALP) phosphorus (P) concentrations to diagnose severity of metabolic disease prematurity.A total 336 (≤ 31 weeks' gestation birth weight ≤ 1500 g) were prospectively evaluated BMD before using dual-energy X-ray absorptiometry.BMD reference (at ALP 500 IU/L) measured 279 patients. was classified as poor (<10th percentile) <0.068 g/cm(2), fair...
ABSTRACT Objective To develop and evaluate the performance of a novel method for predicting neonatal respiratory morbidity based on quantitative analysis fetal lung by ultrasound. Methods More than 13 000 non‐clinical images 900 were used to computerized texture machine learning algorithms, trained predict risk ultrasound images. The method, termed ‘quantitative maturity analysis’ ( quantusFLM ™), was then validated blindly in 144 neonates, delivered at 28 + 0 39 weeks' gestation. Lung DICOM...
The objective of this study was to assess whether the use high-dose intravenous immunoglobulin (IVIG) in late-preterm and term newborns with severe isoimmune hemolytic jaundice caused by Rh ABO incompatibility a risk factor for necrotizing enterocolitis (NEC).An observational, retrospective that encompassed 16 years conducted. A total 492 liveborn infants who were >or=34 weeks' gestation had (n = 91) 401) treated phototherapy included study. IVIG (500 mg/kg over 2-4 hours) indicated when...
Prematurity is associated with cerebral abnormalities that might account for poorer cognitive performance. The aim of our study was to investigate the correlations between corpus callosum reductions and neuropsychologic performance in adolescents who were born preterm. Twenty-five subjects before 33 weeks' gestation compared 25 at term similar age, gender, sociocultural status. All underwent magnetic resonance imaging examinations. Premature performed worse than controls global functioning,...
To investigate whether signs of placental underperfusion (PUP), defined as any maternal and/or fetal vascular pathology, confer an increased risk neonatal morbidity in late-onset small-for-gestational-age (SGA) fetuses with normal umbilical artery (UA) Doppler indices.A cohort 126 SGA singleton UA indices that were delivered after 34 weeks' gestation was studied. For each case, the placenta evaluated histologically for PUP using a hierarchical and standardized classification system. Neonatal...
We analysed the effect of exposure to tobacco smoke during pregnancy on fetal growth parameters in 129 term newborns. Children were classified into four depending basis a questionnaire completed by mother. The results confirmed that smoking reduced weight, length, cranial and thoracic perimeters at birth when was due either active or passive smoking. Weight deficits infants whose mothers smoked heavily (458 g) higher than those exposed (192 g). conclude is very important variable should be...
Objective : To investigate the long-term neuropsychological consequences of perinatal asphyxia (PA). Methods A group adolescents were assessed with antecedents mild ( n = 8) and moderate 20) PA, a matched 28 healthy as control group. Neuropsychological assessment included tests memory, perceptual-motor skills, frontal lobe functions, because these are areas cognitive functioning susceptible to hypoxic conditions. Results Subjects PA showed significant differences from on related delayed...
<b>Objective: </b> To investigate the effects of prematurity on sulcal formation. <b>Methods: We evaluated depth and volume primary olfactory sulcus (developed at 16 weeks9 gestation) secondary orbital sulci (which start to develop 28 in a sample 22 adolescents with history very-preterm birth (VPTB). compared this preterm subjects born term matched by age, gender, sociocultural status. The Anatomist/BrainVISA 3.0.1 package was used identify quantify sulci. In addition, voxel-based...
Prematurity is associated with corpus callosum abnormalities and low general cognitive functioning. The present study explores the specific relationship between gestational age, callosum, intelligence quotient (IQ) in a sample of preterm-born adolescents. Sixty-four adolescents born at age 36 weeks or less were divided into 4 groups attending to their (GA) (group 1, ≤ 27; group 2, 28-30; 3, 31-33; 4, 34-36). These individuals compared 53 term similar gender, sociocultural status. Individuals...
Prematurity is associated with reduced brain volume, and the thalamus among structures most affected. We used a voxel-based morphometry analysis of gray matter to map regional atrophy in sample 30 adolescents antecedents very preterm birth. The was compared controls matched by age, sex, handedness sociocultural status. Individuals birth differed from several thalamic nuclei, semantic phonetic fluency showed different correlation patterns volume. Semantic achieved significant correlations...