A5081811101- Prenatal Screening and Diagnostics
- Assisted Reproductive Technology and Twin Pregnancy
- Pregnancy and preeclampsia studies
- Fetal and Pediatric Neurological Disorders
- Preterm Birth and Chorioamnionitis
- Parvovirus B19 Infection Studies
- Ultrasound Imaging and Elastography
- Pregnancy-related medical research
- Reproductive Biology and Fertility
- Congenital Anomalies and Fetal Surgery
- Birth, Development, and Health
- Neonatal Respiratory Health Research
- Congenital Diaphragmatic Hernia Studies
- Elasticity and Material Modeling
- Ectopic Pregnancy Diagnosis and Management
- Maternal and Perinatal Health Interventions
- Cardiovascular Issues in Pregnancy
- Urological Disorders and Treatments
- Hemoglobinopathies and Related Disorders
- Pediatric health and respiratory diseases
- Gestational Diabetes Research and Management
- Electrochemical Analysis and Applications
- Maternal and fetal healthcare
- Blood groups and transfusion
- Cleft Lip and Palate Research
Hospital del Mar Research Institute
2008-2024
Instituto de Investigación Biosanitaria de Granada
2015-2024
Hospital General Universitario de Alicante Doctor Balmis
2021
Hospital Universitario Virgen de la Arrixaca
2021
University of Exeter
2019
King's College Hospital
2006-2018
Universidad de Granada
1994-2018
Chinese University of Hong Kong
2018
Hospiten Group
2018
University College London
2018
Preterm preeclampsia is an important cause of maternal and perinatal death complications. It uncertain whether the intake low-dose aspirin during pregnancy reduces risk preterm preeclampsia.In this multicenter, double-blind, placebo-controlled trial, we randomly assigned 1776 women with singleton pregnancies who were at high for to receive aspirin, a dose 150 mg per day, or placebo from 11 14 weeks gestation until 36 gestation. The primary outcome was delivery before 37 analysis performed...
ABSTRACT Objective To examine the performance of screening for preterm and term pre‐eclampsia (PE) in study population participating ASPRE (Combined Multimarker Screening Randomized Patient Treatment with Aspirin Evidence‐Based Preeclampsia Prevention) trial. Methods This was a prospective first‐trimester multicenter on PE 26 941 singleton pregnancies by means an algorithm that combines maternal factors, mean arterial pressure, uterine artery pulsatility index serum pregnancy‐associated...
To examine the performance of screening for early, preterm and term pre-eclampsia (PE) at 11-13 weeks' gestation by maternal factors combinations mean arterial pressure (MAP), uterine artery (UtA) pulsatility index (PI), serum placental growth factor (PlGF) pregnancy-associated plasma protein-A (PAPP-A).The data this study were derived from three previously reported prospective non-intervention studies 11 + 0 to 13 6 in a combined total 61 174 singleton pregnancies, including 1770 (2.9%)...
Abstract Objectives To use multiple regression analysis to define the contribution of maternal variables that influence measured concentration free beta‐human chorionic gonadotropin (β‐hCG) and pregnancy‐associated plasma protein‐A (PAPP‐A), interaction between these covariates, in first‐trimester biochemical screening for trisomy 21. Methods This was a multicenter study prospective 21 by combination fetal nuchal translucency thickness, serum β‐hCG PAPP‐A at 11 + 0 13 6 weeks gestation. In...
ABSTRACT Objective To examine the diagnostic accuracy of a previously developed model for prediction pre‐eclampsia ( PE ) by combination maternal factors and biomarkers at 11–13 weeks' gestation. Methods This was prospective first‐trimester multicenter study screening in 8775 singleton pregnancies. A published algorithm used calculation patient‐specific risk each individual. The detection rates DRs false‐positive FPRs delivery with < 32, 37 ≥ weeks were estimated compared those dataset...
Abstract Objective Fetal nuchal translucency (NT) thickness increases with crown–rump length (CRL). In screening for chromosomal defects patient‐specific risks are derived by multiplying the a priori maternal age‐related risk likelihood ratio, determined from deviation of measured NT expected median. To quantify this is either subtracted (delta NT) or divided median (multiple method, MoM). This study examines validity these methods. Methods was prospectively at 11 + 0 to 13 6 weeks in...
In Brief OBJECTIVE: To examine the prevalence and distribution of all chromosomal defects in fetuses with increased nuchal translucency thickness. METHODS: Assessment risk for trisomy 21 was carried out by a combination maternal age fetal thickness at 11–13 + 6 weeks. A search database made to identify, first, singleton pregnancies which karyotyping and, second, cases where equal or above 95th centile crown-rump length. The were determined each category: between length 3.4 mm, 3.5–4.4...
Abstract Objectives To examine the clinical utility of first‐trimester biochemical markers aneuploidy in their ability to predict subsequent delivery a small‐for‐gestational age (SGA) infant. Methods We examined singleton pregnancies with no chromosomal abnormality and complete outcome data that had undergone screening for trisomy 21 by combination fetal nuchal translucency (NT) thickness maternal serum free β‐human chorionic gonadotropin (β‐hCG) pregnancy‐associated plasma protein‐A...
To assess a new method for numerical quantification of cervical elastography during pregnancy and to evaluate the repeatability measurements.Cervical was carried out twice by single operator in 112 singleton pregnancies at median 21 (range, 12-40) weeks' gestation. In 50 cases second performed another measurement. The intraobserver interobserver measurements different parts cervix were assessed using intraclass correlation coefficients with 95% CI Bland-Altman analysis.There no statistically...
Abstract Objectives The aims of this study were, first, to establish the agreement between digital and ultrasound assessment occipital position and, second, evaluate repeatability measurements head direction, angle middle line, progression distance in women second stage labor. Methods Digital examination then transabdominal was performed on 50 labor determine fetal position. We also obtained three‐dimensional (3D) blocks by transperineal sonography, two experts 3D measured progression....
ABSTRACT Objectives To examine the effect of first‐trimester screening for pre‐eclampsia (PE) on prediction delivering a small‐for‐gestational‐age (SGA) neonate and prophylactic use aspirin prevention SGA. Methods The data this study were derived from two multicenter studies. In SPREE, we investigated performance PE by combination maternal characteristics biomarkers at 11–13 weeks' gestation. ASPRE, women with singleton pregnancy identified combined as being high risk preterm (> 1 in 100)...
The glitazones or thiazolidinediones are ligands of the peroxisome proliferator-activated receptor gamma (PPARgamma). used in treatment diabetes, regulate adipogenesis, inflammation, cell proliferation, and induce apoptosis several cancer types. High grade astrocytomas rapidly growing tumors derived from astrocytes, for which new treatments needed. We determined effects two glitazones, ciglitazone therapeutic rosiglitazone, on survival serum-deprived primary rat astrocytes glioma lines C6...
To examine the clinical utility of first-trimester markers aneuploidy in their ability to predict preterm delivery.We examined 54 722 singleton pregnancies with no chromosomal abnormality and complete outcome data that had undergone screening for trisomy 21 by a combination fetal nuchal translucency (NT) thickness maternal serum free beta-human chorionic gonadotropin (beta-hCG) pregnancy-associated plasma protein-A (PAPP-A) at 11 + 0 13 6 weeks' gestation. The biochemical were converted...
Abstract Objective To establish reference intervals for fetal heart stroke volume and cardiac output with gestation. Methods Fetal ventricular volumes were measured using the four‐dimensional (4D) spatiotemporal imaging correlation (STIC) ultrasound technique in 140 normal singleton pregnancies at 12–34 weeks' The Virtual Organ Computer‐aided AnaLysis (VOCAL) was used to obtain a sequence of six sections each systole diastole. Each obtained after 30° rotation from previous one around fixed...
(Abstracted from N Engl J Med 2017;377:613–622) Since 1979, multiple studies have shown that low-dose aspirin in pregnancy can lower the occurrence of preeclampsia. Subsequent doses greater than 100 mg/d started before 16 weeks gestation are most effective.
In Brief OBJECTIVE: To estimate the incidence of septations in fetuses with increased nuchal translucency (NT) thickness, and to investigate relationship between length thickness whether or provide useful information concerning fetal karyotype addition that provided by NT alone. METHODS: We examined 386 equal above 95th percentile for crown-rump (CRL). A transverse suboccipitobregmatic section head was taken determine sonolucency septated, a midsagittal longitudinal used measure CRL,...
Effective first-trimester screening for pre-eclampsia (PE) can be achieved using a competing-risks model that combines risk factors from the maternal history with multiples of median (MoM) values biomarkers. A new artificial intelligence through machine-learning methods has been shown to achieve similar performance without need conversion raw data biomarkers into MoM. This study aimed investigate whether this used across populations specific adaptations.
<h3>Abstract</h3> <b>Objective</b> To investigate an approach for the analysis of samples obtained in screening trisomy 21 that retains advantages quantitative fluorescent polymerase chain reaction (qf-PCR) over full karyotyping and maximises detection clinically significant abnormalities. <b>Design</b> Observational study. <b>Setting</b> Tertiary referral centre. <b>Subjects</b> 17 446 pregnancies, from which chorionic villous had been taken after assessment risk by measurement fetal nuchal...
Abstract Objective False positive diagnosis of preterm labor is common. As a consequence, medications including corticosteroids to promote fetal lung maturity and tocolysis are prescribed unnecessarily. We tested the hypothesis that management threatened based on measurement cervical length by ultrasonography can reduce number women who receive inappropriate treatment. Methods Forty‐one with for whom clinical decision was made prescribe antenatal were randomized have their measured...