A5080220991- Pregnancy and preeclampsia studies
- Prenatal Screening and Diagnostics
- Birth, Development, and Health
- Congenital Anomalies and Fetal Surgery
- Gestational Diabetes Research and Management
- Assisted Reproductive Technology and Twin Pregnancy
- Parvovirus B19 Infection Studies
- Congenital Diaphragmatic Hernia Studies
- Fetal and Pediatric Neurological Disorders
- Neonatal Respiratory Health Research
- Preterm Birth and Chorioamnionitis
- Maternal and fetal healthcare
- Cardiovascular Issues in Pregnancy
- Ectopic Pregnancy Diagnosis and Management
- Pregnancy-related medical research
- Blood groups and transfusion
- Maternal and Perinatal Health Interventions
- Reproductive System and Pregnancy
- Congenital Heart Disease Studies
- Tracheal and airway disorders
- Pregnancy and Medication Impact
- Renal and related cancers
- Hemoglobinopathies and Related Disorders
- Gestational Trophoblastic Disease Studies
- Cleft Lip and Palate Research
King's College Hospital
2016-2025
Harris Birthright Research Centre for Fetal Medicine
2016-2025
King's College London
2016-2025
King's College Hospital NHS Foundation Trust
2011-2025
St Thomas' Hospital
1990-2024
Health and Human Development (2HD) Research Network
2021-2024
The London College
2024
Genomics (United Kingdom)
2024
Anna Needs Neuroblastoma Answers
2020-2024
Maine Farmland Trust
2024
Preterm preeclampsia is an important cause of maternal and perinatal death complications. It uncertain whether the intake low-dose aspirin during pregnancy reduces risk preterm preeclampsia.In this multicenter, double-blind, placebo-controlled trial, we randomly assigned 1776 women with singleton pregnancies who were at high for to receive aspirin, a dose 150 mg per day, or placebo from 11 14 weeks gestation until 36 gestation. The primary outcome was delivery before 37 analysis performed...
OBJECTIVE--To examine the significance of fetal nuchal translucency at 10-14 weeks9 gestation in prediction abnormal karyotype. DESIGN--Prospective screening study. SETTING--The Harris Birthright Research Centre for Fetal Medicine, King9s College Hospital, London. SUBJECTS--827 fetuses undergoing first trimester karyotyping by amniocentesis or chorionic villus sampling. MAIN OUTCOME MEASURE--Incidence chromosomal defects. RESULTS--The incidence defects was 3% (28 827 cases). In 51 (6%) with...
Previous randomized trials have shown that progesterone administration in women who previously delivered prematurely reduces the risk of recurrent premature delivery. Asymptomatic found at midgestation to a short cervix are greatly increased for spontaneous early preterm delivery, and it is unknown whether this such women.
To validate the clinical efficacy and practical feasibility of massively parallel maternal plasma DNA sequencing to screen for fetal trisomy 21 among high risk pregnancies clinically indicated amniocentesis or chorionic villus sampling.Diagnostic accuracy validated against full karyotyping, using prospectively collected archived samples.Prenatal diagnostic units in Hong Kong, United Kingdom, Netherlands.753 pregnant women at who underwent definitive diagnosis by whom 86 had a fetus with 21....
In an ultrasound screening study at 10 to 14 weeks of gestation for measurement fetal nuchal translucency thickness there were 102 monochorionic and 365 dichorionic twin pregnancies. the compared with pregnancies was a higher rate loss before 24 (12.2% versus 1.8%), perinatal mortality (2.8% 1.6%), prevalence delivery 32 (9.2% 5.5%), birthweight below 5th centile in both twins (7.5% 1.7%). However, proportion discordancy more than 25% similar two groups (11.3% 12.1%).
<h3>Abstract</h3> <b>Objectives:</b> To examine the utility of measuring fetal nuchal translucency thickness in screening for major defects heart and great arteries at 10-14 weeks gestation. <b>Design:</b> Population based cohort study. <b>Subjects:</b> 29 154 singleton pregnancies with chromosomally normal fetuses <b>Setting:</b> Fetal medicine centre London. <b>Main outcome measure:</b> Prevalence arteries. <b>Results:</b> Of 50 cases (prevalence 1.7 per 1000 pregnancies) 28 (56%, 95%...
Abstract Objective To examine the potential impact of combining maternal age with fetal nuchal translucency thickness and serum free β‐human chorionic gonadotropin (β‐hCG) pregnancy‐associated plasma protein‐A (PAPP‐A) in screening for trisomy 21 at 10–14 weeks gestation. Methods Maternal β‐hCG PAPP‐A were measured by Kryptor, a random access immunoassay analyzer using time‐resolved amplified cryptate emission, 210 singleton pregnancies 946 chromosomally normal controls, matched age,...
Abstract Objective To assess the value of antenatally determined observed to expected fetal lung area head circumference ratio (LHR) in prediction postnatal survival isolated, congenital diaphragmatic hernia (CDH). Methods Two groups fetuses were examined. The first group included 650 normal at 12–32 weeks' gestation, and data collected used establish a range LHR with gestational age. second retrospective multicenter study 354 isolated CDH which was measured on one occasion 18–38 gestation....
The International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) is a scientific organization that encourages sound clinical practice, high-quality teaching research related to diagnostic imaging women's healthcare. ISUOG Clinical Standards Committee (CSC) has remit develop Practice Guidelines Consensus Statements as educational recommendations provide healthcare practitioners with consensus-based approach, from experts, for imaging. They are intended reflect what considered by...
Objective: To develop models for prediction of preeclampsia (PE) based on maternal characteristics, biophysical and biochemical markers at 11–13 weeks’ gestation in which the time delivery PE is treated as a continuous variable. Methods: This was screening study singleton pregnancies weeks including 1,426 (2.4%) that subsequently developed 57,458 were unaffected by PE. We survival model Bayes’ theorem used to combine prior information from characteristics with uterine artery pulsatility...
Abstract Objective To determine the value of transvaginal color Doppler assessment uterine arteries at 23 weeks gestation in predicting subsequent development pre‐eclampsia and fetal growth restriction. Patients methods Women with singleton pregnancies attending for routine ultrasound examination any one seven hospitals underwent arteries. The presence an early diastolic notch waveform was noted, mean pulsatility index two calculated. Screening characteristics prediction delivery a low...
Abstract Objective To examine the potential value of routine measurement cervical length in singleton pregnancies at 23 weeks gestation prediction risk for early spontaneous preterm delivery. Methods Cervical was measured by sonography 2567 women attending antenatal care. In 43 women, ≤15 mm and 21 these were managed expectantly, whereas 22 cases a cerclage placed. that relation between delivery examined ≤ 32 estimated. Results 15 1.7% cases; this group contained 86%, 58% 20% delivered...
PROBLEM: We determined the evolution of maternal‐fetal transport immunoglobulins during human pregnancy. METHOD: Paired blood samples were collected between 17–41 weeks gestation (WG) by puncture a peripheral maternal vein and cordocentesis (17–36 WG, n=91) or directly at delivery (37–41 n=16) from umbilical vein. Additional same individual (n=16) 10,20,30 term. The concentration IgG its four subclasses IgA in sera using ELISA method. RESULTS: mean level 9–16 WG was 13.72±2.53 g/L 3.95±1.23...