A5026235423- Congenital Diaphragmatic Hernia Studies
- Neonatal Respiratory Health Research
- Pediatric Pain Management Techniques
- Anesthesia and Sedative Agents
- Infant Development and Preterm Care
- Congenital Anomalies and Fetal Surgery
- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Congenital Heart Disease Studies
- Pharmaceutical studies and practices
- Antibiotics Pharmacokinetics and Efficacy
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- Respiratory Support and Mechanisms
- Intestinal Malrotation and Obstruction Disorders
- Clinical Nutrition and Gastroenterology
- Tracheal and airway disorders
- Anesthesia and Pain Management
- Mechanical Circulatory Support Devices
- Esophageal and GI Pathology
- Infant Nutrition and Health
- Pharmacogenetics and Drug Metabolism
- Metabolism and Genetic Disorders
- Traumatic Brain Injury Research
- Trauma and Emergency Care Studies
Erasmus MC - Sophia Children’s Hospital
2016-2025
Erasmus MC
2016-2025
Erasmus University Rotterdam
2011-2025
Charles University
2018-2024
Monash University
2020-2022
University of Groningen
2022
University Hospital Bonn
2022
Universität Innsbruck
2016-2021
Innsbruck Medical University
2016-2021
KU Leuven
2007-2021
Abstract Objective To assess the value of antenatally determined observed to expected fetal lung area head circumference ratio (LHR) in prediction postnatal survival isolated, congenital diaphragmatic hernia (CDH). Methods Two groups fetuses were examined. The first group included 650 normal at 12–32 weeks' gestation, and data collected used establish a range LHR with gestational age. second retrospective multicenter study 354 isolated CDH which was measured on one occasion 18–38 gestation....
<h3>Background</h3> Despite an increasing awareness regarding pain management in neonates and the availability of published guidelines for treatment procedural pain, preterm experience leading to short- long-term detrimental effects. <h3>Objective</h3> To assess frequency use analgesics invasive procedures associated burden this population. <h3>Methods</h3> For 151 neonates, we prospectively recorded all painful procedures, including number attempts required, analgesic therapy used during...
In 2010, the congenital diaphragmatic hernia (CDH) EURO Consortium published a standardized neonatal treatment protocol. Five years later, number of participating centers has been raised from 13 to 22. this article relevant literature is updated, and consensus reached between members CDH Consortium. Key updated recommendations are: (1) planned delivery after gestational age 39 weeks in high-volume tertiary center; (2) neuromuscular blocking agents be avoided during initial room; (3) adapt...
Recent trials have questioned the benefit of early parenteral nutrition in adults. The effect on clinical outcomes critically ill children is unclear.We conducted a multicenter, randomized, controlled trial involving 1440 to investigate whether withholding for 1 week (i.e., providing late nutrition) pediatric intensive care unit (ICU) clinically superior nutrition. Fluid loading was similar two groups. primary end points were new infection acquired during ICU stay and adjusted duration...
The aim of this study was to test the reliability and validity COMFORT scale as a postoperative pain instrument for children aged 0–3 years. Subjects were 158 neonates toddlers after major abdominal or thoracic surgery. Trained nurses rated children's at 3, 6 9 h on Pediatric Surgical Intensive Care Unit using VAS pain. Interrater items proved be good (Kappa 0.63–0.93) all with exception item ‘Respiratory response’, which moderate 0.54). LISREL analyses showed that structure data best...
This study assessed the clinical indicators and severity of dysphagia in a representative sample children with severe generalized cerebral palsy intellectual disability. A total 166 (85 males, 81 females) Gross Motor Function Classification System Level IV or V IQ<55 were recruited from 54 daycare centres. Mean age was 9 years 4 months (range 2y 1mo–19y 1mo). Clinically apparent presence standardized mealtime observation, Dysphagia Disorders Survey (DDS), scale. Additional measures...
Congenital diaphragmatic hernia (CDH) is associated with high mortality and morbidity. To date, there are no standardized protocols for the treatment of infants this anomaly. However, based on literature expert opinion might improve outcome. This paper a consensus statement from CDH EURO Consortium prepared aim achieving postnatal in European countries. During meeting between high-volume centers expertise Europe (CDH Consortium), most recent was discussed. Thereafter, 5 experts graded...
To determine the optimal initial ventilation mode in congenital diaphragmatic hernia.Congenital hernia is a life-threatening anomaly with significant mortality and morbidity. The maldeveloped lungs have high susceptibility for oxygen damage resulting incidence of bronchopulmonary dysplasia (BPD) chronic respiratory morbidity.An international, multicenter study (NTR 1310), VICI-trial was performed prenatally diagnosed infants (n = 171) born between November 2008 December 2013, who were...
Importance Continuous morphine infusion as standard postoperative analgesic therapy in young infants is associated with unwanted adverse effects such respiratory depression.Objective To determine whether intravenous paracetamol (acetaminophen) would significantly (Ͼ30%) reduce requirements neonates and after major surgery.Design, Setting, Patients Single-center, randomized, double-blind study conducted a level 3 pediatric intensive care unit Rotterdam, the Netherlands.Patients were 71 or...
<b><i>Objective:</i></b> To study whether new pharmacological and nonpharmacological guidelines lowered numbers of painful procedures in neonates changed the amount frequency analgesic therapy as compared to results our previous 2001. <b><i>Design:</i></b> A prospective observational study. <b><i>Setting:</i></b> Level III NICU Erasmus MC-Sophia Children's Hospital, Rotterdam....
Polychlorinated biphenyls (PCBs) are persistent environmental pollutants which exert a variety of toxic effects in animals, including disturbances sexual development and reproductive function. The estrogenic PCBs may be mediated part by hydroxylated PCB metabolites (PCB-OHs), but the mechanisms they brought about not understood. as well PCB-Hs show low affinities for both alpha beta estrogen receptor isoforms. In present study we demonstrate that various environmentally relevant PCB-OHs...
Newborns admitted to neonatal intensive care units (NICUs) undergo a variety of painful procedures and stressful events. Because the effect continuous morphine infusion in preterm neonates has not been investigated systematically, there is confusion regarding whether should be used routinely this setting.To evaluate effects intravenous on pain responses, incidence intraventricular hemorrhage (IVH), poor neurologic outcome (severe IVH, periventricular leukomalacia, or death).A randomized,...
Objectives: The original COMFORT scale, including both observational and physiologic items, has been validated for measuring distress in children admitted to a pediatric intensive care unit. However, variables are influenced by drugs given the unit setting. objectives of this study were assess usefulness judgment sedation determine new cutoff points "behavioral" scale (COMFORT-B), using only items. Design: Prospective study. Setting: Pediatric university hospital Patients: Seventy-eight...
Congenital diaphragmatic hernia is a significant cause of neonatal mortality. The objective this study was to evaluate the clinical factors associated with death in infants congenital by using large multicenter data set.This prospective cohort all liveborn who were cared for at tertiary referral centers belonging Diaphragmatic Hernia Study Group between 1995 and 2004. Factors thought influence included birth weight, Apgar scores, size defect, anomalies. Survival hospital discharge, duration...
Does pain or tissue damage in early life lead to hyperalgesia persisting into childhood? We performed a cross-sectional study 164 infants investigate whether major surgery within the first 3 months of increases sensitivity subsequent and elucidate same dermatome different leads differences sensitivity. All received standard intraoperative postoperative management, with rescue analgesia guided by treatment algorithm. Differences during were assessed fentanyl intake (nor)epinephrine plasma...