A5089942191- Hepatocellular Carcinoma Treatment and Prognosis
- Congenital Diaphragmatic Hernia Studies
- Pancreatic and Hepatic Oncology Research
- Neonatal Respiratory Health Research
- Organ Transplantation Techniques and Outcomes
- Neuroblastoma Research and Treatments
- Liver Disease and Transplantation
- Cardiac, Anesthesia and Surgical Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
- Agricultural Economics and Policy
- Cancer, Hypoxia, and Metabolism
- Congenital Anomalies and Fetal Surgery
- Intestinal Malrotation and Obstruction Disorders
- Appendicitis Diagnosis and Management
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hernia repair and management
- Hospital Admissions and Outcomes
- Global Trade and Competitiveness
- Global trade and economics
- Economic Growth and Productivity
- Cell death mechanisms and regulation
- Tracheal and airway disorders
- Diversity and Career in Medicine
- Economics of Agriculture and Food Markets
- Mechanical Circulatory Support Devices
University of Tennessee Health Science Center
2014-2024
St. Jude Children's Research Hospital
2014-2024
Le Bonheur Children's Hospital
2009-2023
Academic Pediatric Association
2021
British Columbia Children's Hospital
2019
Children's Oncology Group
2017
Boston Children's Hospital
2014-2017
Dana-Farber Cancer Institute
2017
UC Davis Comprehensive Cancer Center
2017
Siemens (Germany)
2017
<h3>Objective</h3> To compare the effectiveness and adverse event rates of early vs interval appendectomy in children with perforated appendicitis. <h3>Design</h3> Nonblinded randomized trial. <h3>Setting</h3> A tertiary-referral urban children's hospital. <h3>Patients</h3> total 131 patients younger than 18 years a preoperative diagnosis <h3>Interventions</h3> Early (within 24 hours admission) (6-8 weeks after diagnosis). <h3>Main Outcome Measures</h3> Time away from normal activities...
Objective To evaluate the impact of a nonstandard ventilation strategy on survival in congenital diaphragmatic hernia (CDH). Background Despite recent advances, including nitric oxide, CDH remains an unsolved problem with mortality rate 35% to 50%. Hyperventilation and alkalization remain common therapies. Methods In 1992, authors prospectively abandoned hyperventilation alkalization. Patients are lightly sedated ventilated lowest pressure providing adequate chest movement, is set patient...
The objective of this paper is to review the results combined resection liver and inferior vena cava for hepatic malignancy. morbidity mortality along with preliminary survival data are assessed in order determine utility aggressive approach otherwise unresectable tumors.Involvement has traditionally been considered a contraindication advanced tumors because surgical risks high long-term prognosis poor. Progress surgery allows some cases.Twenty-two patients undergoing from 1997 2003, that...
We report the case of a hepatic undifferentiated (embryonal) sarcoma (UES) arising within mesenchymal hamartoma (MH) in 15-year-old girl. Mapping tumor demonstrated typical MH transforming gradually into UES composed anaplastic stromal cells. When evaluated by flow cytometry, was diploid and showed prominent aneuploid peak. Karyotypic analysis structural alterations chromosome 19, which have been implicated as potential genetic marker MH. The histogenesis is still debated, reports...
Hepatitis C virus (HCV) infection is a global health problem affecting 170 million individuals worldwide. In the United States, there are approximately 7 adults and 100,000 children chronically infected with HCV (1,2). The importance of stems from its proclivity to cause insidious liver damage over many years, including chronic hepatitis, cirrhosis, cancer. adults, leading for cancer worldwide (3). financial burden this viral staggering, projected medical costs $10.7 billion in 2010 2019...
The identification of new therapies for high-risk (HR) hepatoblastoma is challenging. Children's Oncology Group study AHEP0731 included a HR stratum to explore the efficacy novel agents. Herein, authors report response rate combination vincristine (V) and irinotecan (I) outcome patients with hepatoblastoma.Patients newly diagnosed metastatic or those serum α-fetoprotein (AFP) level <100 ng/mL were eligible. Patients received 2 cycles V at dose 1.5 mg/m2 /day intravenously on days 1 8 I 50 5....
Involvement of the hepatic veins requiring reconstruction has traditionally been considered a contraindication to resection for advanced tumors liver because surgical risks are high and long-term prognosis poor. Recent advances in surgery gleaned from split live donor transplantation that necessitate vein can be applied some cases.Sixteen patients who underwent 1996-2001 were reviewed. The mean age was 43 years (range 2-61). Nine resected hepatocellular carcinoma (HCC), five colorectal...
Purpose To determine whether the pattern of lung nodules in children with metastatic hepatoblastoma (HB) correlates outcome. Methods Thirty-two patients HB were enrolled on Children’s Oncology Group Protocol AHEP0731 and treated vincristine irinotecan (VI). Responders to VI received two additional cycles intermixed six cisplatin/fluorouracil/vincristine/doxorubicin (C5VD), nonresponders C5VD alone. Patients imaged after every at conclusion therapy. All computed tomography scans pathology...
African American children are more than twice as likely to die after surgery compared with white children. In this study, we evaluated whether risk factors for death differ and children, also assessed race-specific stratification models perform better non-race-specific models.The National Surgical Quality Improvement Program Pediatric Participant Use Data File contains clinical data on operations performed at participating institutions in the United States. Variables predictive of within 30...
Background The Children's Oncology Group (COG) adopted cisplatin, 5‐flourouracil, and vincristine (C5V) as standard therapy after the INT‐0098 legacy study showed statistically equivalent survival but less toxicity in comparison with cisplatin doxorubicin. Subsequent experience demonstrated doxorubicin to be effective patients recurrent disease C5V, this suggested that it could incorporated intensify for advanced disease. Methods In nonrandomized, phase 3 COG trial, primary aim was explore...