A5034374604- Neuroblastoma Research and Treatments
- Cancer therapeutics and mechanisms
- Childhood Cancer Survivors' Quality of Life
- Lung Cancer Research Studies
- Cancer, Hypoxia, and Metabolism
- Neuroendocrine Tumor Research Advances
- Neutropenia and Cancer Infections
- Acute Lymphoblastic Leukemia research
- Palliative Care and End-of-Life Issues
- Hepatocellular Carcinoma Treatment and Prognosis
- Ethics and Legal Issues in Pediatric Healthcare
- Lung Cancer Treatments and Mutations
- Adrenal and Paraganglionic Tumors
- Hematopoietic Stem Cell Transplantation
- Testicular diseases and treatments
- Pancreatic and Hepatic Oncology Research
- Sarcoma Diagnosis and Treatment
- Renal and related cancers
- Glioma Diagnosis and Treatment
- Virus-based gene therapy research
- Acute Myeloid Leukemia Research
- Cancer Treatment and Pharmacology
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- CAR-T cell therapy research
St. Jude Children's Research Hospital
2015-2024
University of Tennessee Health Science Center
2012-2023
University of Tennessee at Knoxville
1996-2017
Children's Oncology Group
2002-2017
Cincinnati Children's Hospital Medical Center
2004-2017
Boston Children's Hospital
2017
Dana-Farber Cancer Institute
2017
UC Davis Comprehensive Cancer Center
2017
MSD K.K. (Japan)
2017
Siemens (Germany)
2017
The viewpoint of the terminally ill child at time an end-of-life decision has not been formally investigated. We identified preferences children and adolescents with advanced cancer about their care factors that influenced decisions.Pediatric patients 10 or more years age were interviewed within 7 days participating in one following three decisions: enrollment onto a phase I trial (n = 7), adoption do resuscitate order 5), initiation terminal 8). patient, parent, primary pediatric oncologist...
When a child's cancer progresses beyond current treatment capability, the parents are likely to participate in noncurative decision making. One factor that helps make these decisions and remain satisfied with them afterward is deciding as they believe good parent would decide. Because being child incurable has not been formally defined, we conducted descriptive study develop such definition.In face-to-face interviews, 62 who had made one of three (enrollment on phase I study, do resuscitate...
PURPOSE: In a preclinical model of neuroblastoma, administration irinotecan daily 5 days per week for 2 consecutive weeks ([qd × 5] 2) resulted in greater antitumor activity than did single 5-day course with the same total dose. We evaluated this protracted schedule children. PATIENTS AND METHODS: Twenty-three children refractory solid tumors were enrolled onto phase I study. Cohorts received by 1-hour intravenous infusion at 20, 24, or 29 mg/m (qd 5) every 21 days. RESULTS: The 23 (median...
In forty fresh human cadaver knees the function of anterior cruciate ligament and its two component parts, posterolateral part anteromedial band, were studied by cutting these ligaments others in different sequences combinations then manually stressing knees. The drawer sign cannot be obtained unless band is severed. postolateral medial collateral are, respectively, secondary tertiary restraints limiting sign. Both internal external rotation are limited ligament, especially when knee...
PURPOSE Leukemic cell characteristics were analyzed in infants less than 1 year of age with acute lymphoblastic leukemia (ALL) to determine adverse prognostic factors that might explain the poor prognosis this group. PATIENTS AND METHODS Treatment outcomes according presenting clinical and laboratory features 30 treated between May 1979 April 1993. A stepwise multivariate regression model was used identify most important indicator respect event-free survival. RESULTS Infant ALL cases...
Summary Background: The presence of a mediastinal mass in child poses significant anesthesia‐related risks including death. To optimize outcome clinicians must be able to predict which patients are at highest risk anesthetic complications. Methods: We conducted retrospective review 118 pediatric who presented with masses. investigated their medical records for clinical symptoms and signs presentation reviewed chest radiographs, computed tomography scans, echocardiograms electrocardiograms...
The purpose of this study was to compare the diagnostic utility 123I-metaiodobenzylguanidine (123I-MIBG) scintigraphy and 18F-FDG PET in neuroblastoma. Methods: A total 113 paired 123I-MIBG scans 60 patients with neuroblastoma were retrospectively reviewed. Paired acquired within 14 days each other. Results: For stage 1 2 (13 scans, 10 patients), depicted more extensive primary or residual 9 13 scans. showed equal numbers lesions 3 scan results normal. (15 local regional metastases 5 15 4...
Purpose To determine the maximum-tolerated dose (MTD), dose-limiting toxicities (DLTs), and pharmacokinetic pharmacodynamic properties of mammalian target rapamycin (mTOR) inhibitor, everolimus, in children with refractory or recurrent solid tumors. Patients Methods Everolimus was administered orally at a daily 2.1, 3, 5, 6.5 mg/m 2 cohorts three to six patients per dosage level. Pharmacokinetic studies were performed during first course. The phosphorylation status various components mTOR...
The c-fms gene product is related, and possibly identical, to the receptor for mononuclear phagocyte colony stimulating factor, CSF-1. Using antisera a recombinant v-fms--coded polypeptide, glycoproteins encoded by human locus were detected in cells from normal peripheral blood promyelocytic HL-60 24 h after induction of monocytic differentiation with phorbol ester. 150-kD c-fms--coded glycoprotein was expressed at cell surface, active as tyrosine-specific protein kinase vitro, shared...
The addition of immunotherapy, including a combination anti-GD2 monoclonal antibody (mAb), ch14.18, and cytokines, improves outcome for patients with high-risk neuroblastoma. However, this therapy is limited by ch14.18-related toxicities that may be partially mediated complement activation. We report the results phase I trial to determine maximum-tolerated dose (MTD), safety profile, pharmacokinetics hu14.18K322A, humanized mAb single point mutation (K322A) reduces complement-dependent...
The combination of gemcitabine and docetaxel has demonstrated promise in sarcomas diagnosed adults. In the current study, toxicity efficacy this were evaluated pediatric sarcomas.A retrospective case review 22 patients with recurrent or refractory bone soft-tissue who received (at a dose 675 mg/m(2) intravenously on Days 1 8) 75-100 Day was undertaken.The (ages 8-23 years) total 109 courses chemotherapy (median, 4 courses; range, 1-13 courses). Seventeen had osteosarcoma, 2 Ewing sarcoma...
Purpose: Anti-GD2 mAbs, acting via antibody-dependent cell-mediated cytotoxicity, may enhance the effects of chemotherapy. This pilot trial investigated a fixed dose unique anti-GD2 mAb, hu14.18K322A, combined with chemotherapy, cytokines, and haploidentical natural killer (NK) cells.Experimental Design: Children recurrent/refractory neuroblastoma received up to six courses hu14.18K322A (40 mg/m2/dose, days 2-5), GM-CSF, IL2 chemotherapy: cyclophosphamide/topotecan (courses 1,2),...
Purpose Treatment outcome for black patients with cancer has been significantly worse than their white counterparts. We determined whether recent improved treatment had narrowed the gap in between and pediatric patients. Patients Methods In a parallel comparison, we analyzed survival by disease category childhood registered one of 17 registries National Cancer Institute's Surveillance, Epidemiology, End Results (SEER) program or treated at St Jude Children's Research Hospital, which provides...
Abstract Purpose: We sought to evaluate whether combining a humanized antidisialoganglioside mAb (hu14.18K322A) with induction chemotherapy improves early responses and outcomes in children newly diagnosed high-risk neuroblastoma. Patients Methods: conducted prospective nonrandomized, single-arm, two-stage, phase II clinical trial. Six courses of were coadministered hu14.18K322A followed granulocyte–macrophage colony-stimulating factor (GM-CSF) low-dose IL2. Consolidation was performed...
Background. Hypercalcemia complicating malignancy is a frequent complication in adults, but little has been published about the pathogenesis or true incidence of hypercalcemia children with cancer. Methods. developing childhood malignancies was studied retrospectively at St. Jude Children's Research Hospital to determine its incidence, timing presentation, and response therapy. Results. Over 29-year period, 25 (median age, 9.5 years) had diagnosed treated for that occurred during course...
OBJECTIVE. Studies of symptoms in children dying a cancer-related death typically rely on medical chart reviews or parental responses to symptom checklists. However, the mere presence does not necessarily correspond with distress it can cause child's parents. The purpose this study was identify that most concerned parents during last days their life and strategies identified as helpful care. METHODS. Sixty-five 52 who had died within previous 6 10 months participated telephone interviews....
PURPOSE To determine the dose-limiting toxicity and potential efficacy of topotecan in pediatric patients with refractory malignant solid tumors. PATIENTS AND METHODS In this phase I clinical trial, 27 received 0.75-1.9 mg/m2 by continuous intravenous infusion daily for 3 days. Fifty-three treatment courses were given to these patients. RESULTS Myelosuppression was at levels 1.3 1.9 days, requiring significant support transfused packed RBCs platelets. variable severity 1.0-mg/m2 dosage...
Abstract BACKGROUND Typhlitis is increasingly recognized in children undergoing chemotherapy but poorly characterized. The authors investigated the demographic, clinical, and imaging (ultrasonography computed tomography [CT] scans) variables related to diagnosis, risk, outcome of typhlitis. METHODS reviewed records patients who had typhlitis (bowel wall thickness ≥ 0.3 cm plus clinical findings) during treatment at St. Jude Children's Research Hospital (Memphis, TN) between 1990 2001. They...
Parents of children with incurable cancer make complex and difficult decisions about remaining treatment options. We compared the self-reported rationale, good parent definition, desired clinical staff behaviors parents who recently decided for phase I (P1) chemotherapy chose a do not resuscitate (DNR) or terminal care (TC) option.Sixty-two 58 were asked basis their decision, definition parent, what supported role. After semantic content analysis, results in P1 versus DNR/TC groups. These...
The identification of new therapies for high-risk (HR) hepatoblastoma is challenging. Children's Oncology Group study AHEP0731 included a HR stratum to explore the efficacy novel agents. Herein, authors report response rate combination vincristine (V) and irinotecan (I) outcome patients with hepatoblastoma.Patients newly diagnosed metastatic or those serum α-fetoprotein (AFP) level <100 ng/mL were eligible. Patients received 2 cycles V at dose 1.5 mg/m2 /day intravenously on days 1 8 I 50 5....
We evaluated whether combining a humanized antidisialoganglioside monoclonal antibody (hu14.18K322A) throughout therapy improves early response and outcomes in children with newly diagnosed high-risk neuroblastoma.