A5086250633- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Adrenal and Paraganglionic Tumors
- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Retinoids in leukemia and cellular processes
- Hematopoietic Stem Cell Transplantation
- Neutropenia and Cancer Infections
- Neuroblastoma Research and Treatments
- Histone Deacetylase Inhibitors Research
- Lymphoma Diagnosis and Treatment
- Protein Degradation and Inhibitors
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Adolescent and Pediatric Healthcare
- Hematological disorders and diagnostics
- Cancer therapeutics and mechanisms
- Viral-associated cancers and disorders
- CAR-T cell therapy research
- Advanced biosensing and bioanalysis techniques
- Sarcoma Diagnosis and Treatment
St. Jude Children's Research Hospital
2016-2025
Children's Hospital
2019-2025
Florida International University
2023
University of Tennessee Health Science Center
2013-2023
Pontifical Catholic University of Rio de Janeiro
2023
University of Southern California
2013-2021
Children's Oncology Group
2021
MSD K.K. (Japan)
2021
Leukemia and Lymphoma Society
2020
John Wiley & Sons (United States)
2020
Prophylactic cranial irradiation has been a standard treatment in children with acute lymphoblastic leukemia (ALL) who are at high risk for central nervous system (CNS) relapse.We conducted clinical trial to test whether prophylactic could be omitted from all newly diagnosed ALL. A total of 498 patients evaluated were enrolled. Treatment intensity was based on presenting features and the level minimal residual disease after remission-induction treatment. The duration continuous complete...
Treatment of cancer with the epipodophyllotoxins (etoposide and teniposide) has been linked to development acute myeloid leukemia (AML) in children adults, but factors that might influence risk this complication therapy are poorly defined. We therefore assessed importance potential for secondary AML 734 consecutive lymphoblastic who attained complete remission received continuation (maintenance) treatment according different schedules epipodophyllotoxin administration.
PURPOSE To conduct a pilot study to determine the safety, feasibility, and engraftment of haploidentical natural killer (NK) cell infusions after an immunosuppressive regimen in children with acute myeloid leukemia (AML). PATIENTS AND METHODS Ten patients (0.7 21 years old) who had completed chemotherapy were first complete remission AML enrolled on Pilot Study Haploidentical Natural Killer Cell Transplantation for Acute Myeloid Leukemia (NKAML) study. They received cyclophosphamide (60...
The incidence of pediatric adrenal cortical carcinoma (ACC) in southern Brazil is 10–15 times higher than that ACC worldwide. Because childhood associated with Li-Fraumeni syndrome, we examined the cancer history and p53 status 36 Brazilian patients their families. Remarkably, 35 had an identical germ-line point mutation encoding R337H amino acid substitution. Differences within intragenic polymorphic markers demonstrated at least some mutant alleles arose independently, thus eliminating a...
We estimated whether single collections of cord blood contained sufficient cells for hematopoietic engraftment adults by evaluating numbers and adult bone marrow myeloid progenitor (MPCs) as detected in vitro with steel factor (SLF) colony-stimulating factors (CSFs). SLF plus granulocyte-macrophage (GM)-CSF 8- to 11-fold more GM progenitors [colony-forming units (CFU)-GM] than stimulated GM-CSF or 5637 conditioned medium (CM), growth previously used estimate CFU-GM numbers. erythropoietin...
We created a registry for pediatric adrenocortical tumors (ACTs), which are rare and not well characterized. provide descriptive analysis of 254 patients registered on the International Pediatric Adrenocortical Tumor Registry.Between January 1990 December 2001, younger than 20 years age with newly diagnosed or previously treated ACTs were registered. A histologic diagnosis ACT was required, although central review mandatory. Follow-up information periodically requested from referring...
Children who survive acute lymphoblastic leukemia are at risk for leukemia-related or treatment-related complications, which can adversely affect survival and socioeconomic status. We determined the long-term rates of health insurance coverage, marriage, employment among patients had attained least 10 years event-free survival.
Infection with the human T-cell lymphotropic virus type I, a retrovirus, can cause distinctive cancer, adult leukemia–lymphoma. The median survival of patients acute and lymphomatous forms disease is short, despite use cytotoxic chemotherapy.
Methotrexate (MTX) can cause significant clinical neurotoxicity and asymptomatic leukoencephalopathy. We sought to identify clinical, pharmacokinetic, genetic risk factors for these MTX-related toxicities during childhood acute lymphoblastic leukemia (ALL) therapy provide data on safety of intrathecal high-dose MTX rechallenge in patients with neurotoxicity.Prospective brain magnetic resonance imaging was performed at four time points 369 children ALL treated a contemporary study that...
Little is known about the incidence of secondary neoplasms after 15 to 20 years in children and adolescents who were treated for acute lymphoblastic leukemia.To investigate cumulative pediatric patients leukemia over 30 characterize late-occurring tumors.Retrospective study 2169 with between 1962 1998 at St Jude Children's Research Hospital, Memphis, Tenn, achieved complete remission had a median follow-up time 18.7 (range, 2.4-41.3 years).Cumulative incidences first standard ratios observed...
Despite contemporary treatment, up to 10% of children with acute lymphoblastic leukemia still experience relapse. We evaluated whether a higher dosage PEG-asparaginase and early intensification triple intrathecal therapy would improve systemic CNS control.
Purpose Adrenocortical carcinoma (ACC) is a rare pediatric malignancy. It occurs in excess among individuals with the Li-Fraumeni syndrome, which results primarily from germline mutations TP53 gene. Prior series exploring frequencies of mutation children ACC have been small, geographically limited, or subject to referral bias. The functional consequence has not related phenotype. We provide genotype-phenotype analysis and propose model for tissue-specific effects based on adrenocortical...
Paediatric adrenocortical carcinoma is a rare malignancy with poor prognosis. Here we analyse 37 tumours (ACTs) by whole-genome, whole-exome and/or transcriptome sequencing. Most cases (91%) show loss of heterozygosity (LOH) chromosome 11p, uniform selection against the maternal chromosome. IGF2 on 11p overexpressed in 100% tumours. TP53 mutations and 17 LOH wild-type are observed 28 ACTs (76%). Chromosomes undergo copy-neutral early during tumorigenesis, suggesting tumour-driver events....
Myelodysplastic syndromes (MDS) are uncommon in children and have a poor prognosis. In contrast to adult MDS, little is known about the genomic landscape of pediatric MDS. Here, we describe somatic germline changes MDS using whole exome sequencing, targeted amplicon and/or RNA-sequencing 46 primary patients. Our data show that, Ras/MAPK pathway mutations common (45% cohort), while RNA splicing genes rare (2% cohort). Surprisingly, variants SAMD9 or SAMD9L were present 17% patients, these...