A5019058700- Childhood Cancer Survivors' Quality of Life
- Lymphoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- CNS Lymphoma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Global Cancer Incidence and Screening
- Ethics and Legal Issues in Pediatric Healthcare
- Medical Imaging Techniques and Applications
- Renal and related cancers
- Reproductive Biology and Fertility
- Palliative Care and End-of-Life Issues
- Viral-associated cancers and disorders
- Acute Myeloid Leukemia Research
- Sarcoma Diagnosis and Treatment
- Child and Adolescent Health
- Advances in Oncology and Radiotherapy
- Chronic Lymphocytic Leukemia Research
- Neutropenia and Cancer Infections
- Health Systems, Economic Evaluations, Quality of Life
- Neuroblastoma Research and Treatments
- Pleural and Pulmonary Diseases
- Chemotherapy-induced cardiotoxicity and mitigation
- Cancer Risks and Factors
- Epigenetics and DNA Methylation
- Chronic Myeloid Leukemia Treatments
St. Jude Children's Research Hospital
2016-2025
University of Tennessee Health Science Center
2015-2025
Médecins Sans Frontières
2023-2025
Hospital de Câncer de Barretos
2023
Novartis (Germany)
2023
Merck (United Kingdom)
2023
University of Tennessee at Knoxville
2009-2022
Children's Research Hospital
2021
Hospital Infantil Dr. Robert Reid Cabral
2018
Hospital Nacional de Niños
2018
Prophylactic cranial irradiation has been a standard treatment in children with acute lymphoblastic leukemia (ALL) who are at high risk for central nervous system (CNS) relapse.We conducted clinical trial to test whether prophylactic could be omitted from all newly diagnosed ALL. A total of 498 patients evaluated were enrolled. Treatment intensity was based on presenting features and the level minimal residual disease after remission-induction treatment. The duration continuous complete...
Methotrexate (MTX) can cause significant clinical neurotoxicity and asymptomatic leukoencephalopathy. We sought to identify clinical, pharmacokinetic, genetic risk factors for these MTX-related toxicities during childhood acute lymphoblastic leukemia (ALL) therapy provide data on safety of intrathecal high-dose MTX rechallenge in patients with neurotoxicity.Prospective brain magnetic resonance imaging was performed at four time points 369 children ALL treated a contemporary study that...
To compare two-dimensional (2D) echocardiography, the current method of screening for treatment-related cardiomyopathy recommended by Children's Oncology Group Guidelines, to cardiac magnetic resonance (CMR) imaging, reference standard left ventricular (LV) function.Cross-sectional, contemporaneous evaluation LV structure and function 2D three-dimensional (3D) echocardiography CMR imaging in 114 adult survivors childhood cancer currently median age 39 years (range, 22 53 years) exposed...
Long-term follow-up data on premature ovarian insufficiency (POI) in childhood cancer survivors are limited. To describe the prevalence of POI, its risk factors, and associated long-term adverse health outcomes. Cross-sectional. The St. Jude Lifetime Cohort Study, an established cohort a tertiary care center. Nine hundred twenty-one participants (median age, 31.7 years) were evaluated at median 24.0 years after diagnosis. POI was defined by persistent amenorrhea combined with...
Abstract Background To facilitate prospective medical assessment of adults surviving pediatric malignancies and advance knowledge about long‐term childhood cancer survivor health, St. Jude Children's Research Hospital (SJCRH) is establishing a lifetime cohort survivors. Methods Eligibility criteria for inclusion in the Lifetime Cohort (SJLIFE) study include: (1) diagnosis malignancy treated at SJCRH; (2) survival ≥ 10 years from diagnosis; (3) current age ≥18 years. Three levels...
The majority of children, adolescents, and young adults diagnosed with cancer will become long-term survivors. Although therapy is associated many adverse effects, one the primary concerns male survivors reproductive health. Future fertility often focus concern; however, it must be recognized that all aspects health, including pubertal development, testosterone production, sexual function, can impaired by therapy. pretreatment strategies to preserve health have been beneficial some patients,...
This portion of the NCCN Guidelines for Hodgkin lymphoma (HL) focuses on management classical HL. Current HL involves initial treatment with chemotherapy or combined modality therapy followed by restaging PET/CT to assess response using Deauville criteria (5-point scale). The introduction less toxic and more effective regimens has significantly advanced cure rates. However, long-term follow-up after completion is essential determine potential effects.
The prognosis for older adolescents and young adults with acute lymphoblastic leukemia (ALL) has been historically much worse than that younger patients. We reviewed the outcome of (age 15 to 18 years) treated in four consecutive Total Therapy studies determine if recent improved treatment extended this high-risk group.
The NCCN Clinical Practice Guidelines in Oncology for Hodgkin Lymphoma (HL) provide recommendations the management of adult patients with HL. panel meets at least annually to review comments from reviewers within their institutions, examine relevant data, and reevaluate update recommendations. Current classic HL involves initial treatment chemotherapy alone or combined modality therapy followed by restaging PET/CT assess response. Overall, introduction less toxic more effective regimens has...
Purpose Treatment outcome for black patients with cancer has been significantly worse than their white counterparts. We determined whether recent improved treatment had narrowed the gap in between and pediatric patients. Patients Methods In a parallel comparison, we analyzed survival by disease category childhood registered one of 17 registries National Cancer Institute's Surveillance, Epidemiology, End Results (SEER) program or treated at St Jude Children's Research Hospital, which provides...
More than 90% of children with favorable-risk Hodgkin lymphoma can achieve long-term survival, yet many will experience toxic effects from radiation therapy. Pediatric oncologists strive for maintaining excellent cure rates while minimizing effects.To evaluate the efficacy 4 cycles vinblastine, Adriamycin (doxorubicin), methotrexate, and prednisone (VAMP) in patients who a complete response after 2 do not receive radiotherapy.Multi-institutional, unblinded, nonrandomized single group phase...