A5069505762- Cardiovascular and exercise physiology
- Glioma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Neuroblastoma Research and Treatments
- Reconstructive Surgery and Microvascular Techniques
- Particle Accelerators and Free-Electron Lasers
- Adhesion, Friction, and Surface Interactions
- Cardiovascular Function and Risk Factors
- Reconstructive Facial Surgery Techniques
- Renal and related cancers
- Heart Rate Variability and Autonomic Control
- Epigenetics and DNA Methylation
- Hearing, Cochlea, Tinnitus, Genetics
- Particle accelerators and beam dynamics
- COVID-19 and healthcare impacts
- Tribology and Lubrication Engineering
- Hemodynamic Monitoring and Therapy
- Ear and Head Tumors
- Cancer Genomics and Diagnostics
- Heart Failure Treatment and Management
- Cardiovascular Effects of Exercise
- Hedgehog Signaling Pathway Studies
- Meningioma and schwannoma management
- Cardiac electrophysiology and arrhythmias
- Cardiac Imaging and Diagnostics
The University of Melbourne
2017-2025
Royal Children's Hospital
2016-2025
Murdoch Children's Research Institute
2015-2025
Royal Australasian College of Physicians
2025
St. Jude Children's Research Hospital
2025
Royal Ottawa Mental Health Centre
2024
Centre for Eye Research Australia
2024
Toronto General Hospital
2022
Fluidigm (Canada)
2022
Fluidigm (United States)
2022
Walking tests, frequently used to document effects of treatment on exercise capacity, have never been standardised. We studied the encouragement walking test performance in a randomised study that controlled for nature underlying disease, time day, and order effects. 43 patients with chronic airflow limitation or heart failure both receive not as they performed serial two six minute walks every fortnight 10 weeks. Simple improved (p less than 0.02 walk), magnitude effect was similar reported...
Recurrent glioblastoma multiforme (GBM) is incurable with current therapies. Biallelic mismatch repair deficiency (bMMRD) a highly penetrant childhood cancer syndrome often resulting in GBM characterized by high mutational burden. Evidence suggests that mutation and neoantigen loads are associated response to immune checkpoint inhibition.We performed exome sequencing prediction on 37 bMMRD cancers compared them adult brain neoplasms. Neoantigen was responsive from multiple tissues. Two...
We studied the effects of exercise training in patients with chronic heart failure attributed to left ventricular dysfunction (ejection fraction, 24 +/- 10%). Twelve ambulatory stable symptoms underwent 4-6 months conditioning by exercising 4.1 0.6 hr/wk at a rate corresponding 75% peak oxygen consumption. Before and after training, maximal bicycle testing direct measurement central hemodynamic, leg blood flow, metabolic responses. Exercise resulted decrease rest submaximal 23% increase...
Recent studies in patients with long-term heart failure have suggested that intrinsic abnormalities skeletal muscle can contribute to the development of early lactic acidosis and fatigue during exercise. The present study provides an analysis substrate enzyme content, fiber typing, capillarization biopsy samples obtained at rest from vastus lateralis 11 (left ventricular ejection fraction, 21 +/- 8%) nine normal subjects. Patients demonstrated a reduced peak exercise oxygen consumption (13.0...
We studied the central hemodynamic, leg blood flow, and metabolic responses to maximal upright bicycle exercise in 30 patients with chronic heart failure attributable severe left ventricular dysfunction (ejection fraction, 24 +/- 8%) 12 normal subjects. At peak exercise, demonstrated reduced oxygen consumption (15.1 4.8 vs. 32.1 9.9 ml/kg/min, p less than 0.001), cardiac output (8.7 3.2 18.6 4.4 l/min, mean systemic arterial pressure (116 15 135 13 mm Hg, 0.01) compared Leg flow was...
This study was designed to determine the pathophysiologic basis of increased exercise ventilation in presence chronic heart failure. Sixty-four ambulatory patients with failure and 38 age-matched normal control subjects performed according identical staged, symptom-limited bicycle protocols measurement hemodynamic, ventilatory, metabolic responses. Compared subjects, ratio CO2 production (Ve/VCO2), pulmonary capillary wedge pressure were elevated at rest during exercise. The dead space tidal...
Cisplatin chemotherapy and surgery are effective treatments for children with standard-risk hepatoblastoma but may cause considerable irreversible hearing loss. This trial compared cisplatin plus delayed administration of sodium thiosulfate, aiming to reduce the incidence severity cisplatin-related ototoxic effects without jeopardizing overall event-free survival.
SJMB03 (ClinicalTrials.gov identifier: NCT00085202) was a phase III risk-adapted trial that aimed to determine the frequency and clinical significance of biological variants genetic alterations in medulloblastoma.
Abstract The COVID‐19 pandemic is one of the most serious global challenges to delivering affordable and equitable treatment children with cancer we have witnessed in last few decades. This Special Report aims summarize general principles for continuing multidisciplinary care during SARS‐CoV‐2 (COVID‐19) pandemic. With contributions from leadership International Society Pediatric Oncology (SIOP), Children's Group (COG), St Jude Global program, Childhood Cancer International, sought provide a...
We have recently demonstrated that exercise training can induce important hemodynamic and metabolic adaptations in patients with chronic heart failure due to severe left ventricular dysfunction. This study examines the accompanying changes submaximal performance ventilatory response these patients. Before after 16-24 weeks of training, subjects underwent two symptom-limited bicycle tests, one an incremental graded workload, a constant workload represented 79 +/- 11% pretraining peak oxygen...
Tumor necrosis factor alpha (TNF-alpha) has been implicated as a key cytokine in many inflammatory lung diseases. These effects are currently unclear, because transgenic mouse overexpressing TNF-alpha the shown separate studies to produce elements of both emphysema and pulmonary fibrosis.We sought elucidate phenotypic overexpression model.We established phenotype by measuring impedance thoracic gas volume, using micro-computed tomography histology.We found that airways resistance this was...
BACKGROUND Exertional fatigue, which frequently limits exercise in patients with chronic heart failure, is associated early anaerobic metabolism skeletal muscle. The present study was designed to examine the muscle metabolic response this disorder and determine relation of reduced blood flow biochemistry histology onset patients. METHODS AND RESULTS We evaluated leg flow, lactate, responses (by vastus lateralis biopsies) during upright bicycle 11 failure (ejection fraction 21 +/- 8%) nine...
To evaluate the effect of gas exchange sampling interval on variability and plateau in O2 uptake (VO2), 10 subjects underwent steady-state treadmill exercise at 50% maximal VO2 6 testing using a ramp protocol. During exercise, data were acquired by different intervals. The was greater as shortened (SD = 4.5 ml.kg-1.min-1 for breath-by-breath vs. 0.8 60-s samples). suggested Gaussian distribution, most attributable to tidal volume (51%). testing, slope change (for each sample) regressed with...
Modern memory systems rely on spatial locality to provide high bandwidth while minimizing device power and cost. The trend of increasing the number cores that share memory, however, decreases apparent because access streams from independent threads are interleaved. Memory scheduling recovers only a fraction original buffering limits. We investigate new techniques reduce inter-thread interference. propose partition internal banks between isolate their eliminate implement this by extending...
We are living very difficult times. The pandemic caused by SARS-CoV-2 (COVID-19) is rapidly affecting the delivery of care for children with cancer around world. have written this commentary to facilitate dissemination helpful information and useful links, place in perspective what we do not know about COVID-19 its impact practice paediatric oncology. Generally speaking, that virus may on population, management cancer, remains unclear poorly documented. next two sections outline has been...