A5046351275- Glioma Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Cancer Immunotherapy and Biomarkers
- Childhood Cancer Survivors' Quality of Life
- Neuroblastoma Research and Treatments
- Cancer Genomics and Diagnostics
- Chromatin Remodeling and Cancer
- Acute Lymphoblastic Leukemia research
- Ocular Oncology and Treatments
- Lymphoma Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Health Systems, Economic Evaluations, Quality of Life
- Acute Myeloid Leukemia Research
- Pituitary Gland Disorders and Treatments
- Lung Cancer Treatments and Mutations
- Hematopoietic Stem Cell Transplantation
- Colorectal Cancer Treatments and Studies
- Fetal and Pediatric Neurological Disorders
- Vascular Malformations Diagnosis and Treatment
- DNA Repair Mechanisms
- Multiple and Secondary Primary Cancers
- Meningioma and schwannoma management
- Radiopharmaceutical Chemistry and Applications
- Chronic Lymphocytic Leukemia Research
- Histiocytic Disorders and Treatments
Tel Aviv Sourasky Medical Center
2014-2024
Tel Aviv University
2013-2024
Schneider Children's Medical Center
2004-2019
Palmetto Hematology Oncology
2018
Alder Hey Children's Hospital
2017
Medical University of Vienna
2017
University of Liverpool
2017
University Medical Center Hamburg-Eppendorf
2017
Brain Tumour Research
2017
Universität Hamburg
2017
Recurrent glioblastoma multiforme (GBM) is incurable with current therapies. Biallelic mismatch repair deficiency (bMMRD) a highly penetrant childhood cancer syndrome often resulting in GBM characterized by high mutational burden. Evidence suggests that mutation and neoantigen loads are associated response to immune checkpoint inhibition.We performed exome sequencing prediction on 37 bMMRD cancers compared them adult brain neoplasms. Neoantigen was responsive from multiple tissues. Two...
Abstract Cancers arising from germline DNA mismatch repair deficiency or polymerase proofreading (MMRD and PPD) in children harbour the highest mutational microsatellite insertion–deletion (MS-indel) burden humans. MMRD PPD cancers are commonly lethal due to inherent resistance chemo-irradiation. Although immune checkpoint inhibitors (ICIs) have failed benefit previous studies, we hypothesized that hypermutation caused by will improve outcomes following ICI treatment these patients. Using an...
To investigate molecular alterations in choroid plexus tumors (CPT) using a genome-wide high-throughput approach to identify diagnostic and prognostic signatures that will refine tumor stratification guide therapeutic options.One hundred CPTs were obtained from multi-institutional tissue clinical database. Copy-number (CN), DNA methylation, gene expression assessed for 74, 36, 40 samples, respectively. Molecular subgroups correlated with parameters outcomes.Unique distinguished carcinomas...
Constitutional mismatch repair deficiency syndrome (CMMRD) is a lethal cancer predisposition characterized by early-onset synchronous and metachronous multiorgan tumors. We designed surveillance protocol for early tumor detection in these individuals.Data were collected from patients with confirmed CMMRD who registered the International Replication Repair Deficiency Consortium. Tumor spectrum, efficacy of protocol, malignant transformation low-grade lesions examined entire cohort. Survival...
Checkpoint inhibitors have limited efficacy for children with unselected solid and brain tumors. We report the first prospective pediatric trial (NCT02992964) using nivolumab exclusively refractory nonhematologic cancers harboring tumor mutation burden (TMB) ≥5 mutations/megabase (mut/Mb) and/or mismatch repair deficiency (MMRD).
Craniopharyngiomas are frequent hypothalamo-pituitary tumors in children, presenting predominantly as cystic lesions. Morbidity from conventional treatment has focused attention on intracystic drug delivery, hypothesized to cause fewer clinical consequences. However, the efficacy of therapy remains unclear. We report retrospective experiences several global centers using interferon-alpha. European Société Internationale d'Oncologie Pédiatrique and International Society for Pediatric...
Objective: To assess the role of 18F-Fluorodeoxyglucose (18F-FDG) PET/CT in pediatric patients with Hodgkin disease (HD) and non-Hodgkin lymphoma (NHL). Materials Methods: 31 patients, mean age 12.9 ± 5.1, HD (n = 24), NHL 7) underwent 18F-FDG at diagnosis studies) later course 75 studies). The findings were correlated diagnostic CT clinical follow-up. Results: resulted a change staging 10 (32.3%), upstaging 7 (22.6%) downstaging 3 (9.6%). On lesion analysis, 164 sites detected by which 38...
Abstract Background Optic pathway gliomas (OPG) are relatively indolent tumors that may occur sporadically or in association with neurofibromatosis 1. Treatment is initiated only when a clear clinical radiological deterioration documented. Chemotherapy the standard first line of treatment. Due to nature this tumor, most important challenge OPG treatment vision preservation. Methods In study we determined visual outcome 19 patients progressive OPGs who received chemotherapy and correlated it...
Hereditary biallelic mismatch repair deficiency (BMMRD) is caused by mutations in the (MMR) genes and manifests features of neurofibromatosis type 1, gastrointestinal (GI) polyposis, GI, brain, hematological cancers. This first study to characterize GI phenotype BMMRD using both retrospective prospective surveillance data.The International Consortium was created collect information on families referred from around world. All patients had germline MMR or lack protein staining normal tumor...
Abstract Background Venous thromboembolism (VTE) is a common event in adults with malignant brain tumors approaching 24% throughout the course of disease. The high morbidity and mortality this complication yielded several protocols for prevention disease undergoing neurosurgery possible primary afterwards. We investigated incidence complications VTE pediatric neuro‐oncology patients. Procedure analyzed, retrospectively, files all consecutive patients under age 18 years who were hospitalized...
Data on the clinical presentation of constitutional mismatch repair deficiency syndrome (CMMRD) is accumulating. However, as extraintestinal manifestations are often fatal and occur at early age, data systematic evaluation gastrointestinal tract scarce. Here we describe 11 subjects with verified biallelic carriage who underwent colonoscopy, upper endoscopy small bowel evaluation. Five were symptomatic in six findings screen detected. Two had colorectal cancer few adenomatous polyps (19, 20...
<h3>BACKGROUND AND PURPOSE:</h3> Biallelic constitutional mutations in DNA mismatch repair genes cause a distinct syndrome, deficiency syndrome (CMMRD), characterized by cancers from multiple organs, most commonly brain tumors, during childhood. Surveillance protocols include total and MR imaging among other modalities to enable early detection of tumors. Brain surveillance scans revealed prominent developmental venous anomalies (DVAs) some patients. DVAs are benign vascular anomalies, their...
Constitutional mismatch repair deficiency (CMMRD) is a highly penetrant cancer predisposition syndrome caused by biallelic mutations in (MMR) genes. As several syndromes are clinically similar, accurate diagnosis critical to screening and treatment. genetic confounded 15 or more pseudogenes variants of uncertain significance, robust diagnostic assay urgently needed. We sought determine whether an that directly measures MMR activity could accurately diagnose CMMRD.In vitro was quantified...
Dvir R, Golander A, Jaccard N, Yedwab G, Otremski I, Spirer Z, Weisman Y. Amniotic fluid and plasma levels of parathyroid hormone-related protein hormonal modulation its secretion by amniotic cells. Eur J Endocrinol 1995;133:277–82. ISSN 0804–4643 Parathyroid (PTHrP), the major mediator humoral hypercalcemia malignancy, may also regulate placental calcium flux, uterine contraction fetal tissue development. In present study, we demonstrated that mean immunoreactive PTHrP concentrations in at...
Optic pathway gliomas (OPG) represent 5% of pediatric brain tumors and compose a major therapeutic dilemma to the treating physicians. While chemotherapy is widely used for these tumors, our ability predict radiological response still lacking. In this study, we use volumetric imaging examine in detail long-term effect on tumor as well its various sub-components.The 15 patients with OPG, treated chemotherapy, were longitudinally measured using novel, previously described method. Patients up...
Immunocompromised patients exposed to varicella may experience significant morbidity and a 7% mortality rate. Management outcome of an outbreak infection among hospitalized pediatric hemato-oncology using the guidelines American Academy Pediatrics Committee on Infectious Diseases are presented.This retrospective study describes between February 2011 June 2011. Data were retrieved from patients' files. Positive polymerase chain reaction results for zoster virus vesicular skin lesions used...
Pediatric low-grade gliomas (LGGs) are the largest group of central nervous system neoplasms in children. Although these tumors generally benign, 5 to 10% patients with pediatric LGGs present leptomeningeal dissemination. The genetic and biological nature is poorly understood. authors looked for certain molecular abnormalities that may differentiate disseminated from other LGGs.Comparative genomic hybridization (CGH) was applied 18 LGGs. Six cases featuring were compared 12 control involving...