A5059455034- Glioma Diagnosis and Treatment
- Epilepsy research and treatment
- Cerebrospinal fluid and hydrocephalus
- Intracranial Aneurysms: Treatment and Complications
- Pharmacological Effects and Toxicity Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Brain Metastases and Treatment
- Meningioma and schwannoma management
- Advanced MRI Techniques and Applications
- Neurosurgical Procedures and Complications
- Vascular Malformations Diagnosis and Treatment
- Neonatal and fetal brain pathology
- Cerebrovascular and Carotid Artery Diseases
- Neuroblastoma Research and Treatments
- Advanced Neuroimaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Functional Brain Connectivity Studies
- Single-cell and spatial transcriptomics
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Head and Neck Surgical Oncology
- Chromatin Remodeling and Cancer
- Radiomics and Machine Learning in Medical Imaging
- Pituitary Gland Disorders and Treatments
- Neurological disorders and treatments
Medical University of Vienna
2016-2025
Comprehensive Cancer Center Vienna
2017-2025
Universitätszahnklinik Wien
2021-2023
Vienna General Hospital
2010-2022
University of Vienna
2021
Utrecht University
2020
Fondation de Rothschild
2019
Kiel University
2015-2018
Brain Tumour Research
2013-2017
Arbeitsgemeinschaft für Klinische Ernährung
2015-2017
Gliomas with histone H3 lysine27-to-methionine mutations (H3K27M-glioma) arise primarily in the midline of central nervous system young children, suggesting a cooperation between genetics and cellular context tumorigenesis. Although H3K27M-glioma are well characterized, their architecture remains uncharted. We performed single-cell RNA sequencing 3321 cells from six primary matched models. found that contain resemble oligodendrocyte precursor (OPC-like), whereas more differentiated malignant...
Abstract Atypical teratoid rhabdoid tumors ( ATRT s) are recently defined highly aggressive embryonal central nervous system with a poor prognosis and no definitive guidelines for treatment. We report on the importance of an initial correct diagnosis disease‐specific therapy outcome in 22 consecutive patients propose new treatment strategy. From 1992 to 2012, nine initially diagnosed correctly as (cohort A, median age 24 months) were treated according intensive multimodal regimen MUV ‐ )...
Diffuse gliomas with K27M histone mutations (H3K27M glioma) are generally characterized by a fatal prognosis, particularly affecting the pediatric population. Based on molecular heterogeneity observed in this tumor type, personalized treatment is considered to substantially improve therapeutic options. Therefore, clinical evidence for therapy, guided comprehensive profiling, urgently required. In study, we analyzed feasibility and outcomes cohort of 12 H3K27M glioma cases treated at two...
Alterations of the fibroblast growth factor (FGF) signalling pathway are increasingly recognized as frequent oncogenic drivers paediatric brain tumours. We report on three patients treated with selective FGFR1-4 inhibitor erdafitinib. Two were diagnosed a posterior fossa ependymoma group A (PFA EPN) and one low-grade glioma (LGG), harbouring FGFR3/FGFR1 overexpression an FGFR1 internal tandem duplication (ITD), respectively. While both EPN did not respond to erdafitinib treatment,...
Diffuse hemispheric gliomas, H3G34R/V-mutant (DHG-H3G34), are lethal brain tumors lacking targeted therapies. They originate from interneuronal precursors; however, leveraging this origin for therapeutic insights remains unexplored. Here, we delineate a cellular hierarchy along the interneuron lineage development continuum, revealing that DHG-H3G34 mirror spatial patterns of progenitor streams surrounding nests, as seen during human development. Integrating these findings with genome-wide...
Coil instability possibly translating into higher delayed rebleeding rates remains a concern in the endovascular management of cerebral aneurysms.To report on 127 patients with aneurysmal remnants who underwent re-treatment over an 18 year period.Patients presenting aneurysm residuals >20% original lesion, unstable neck remnants, regrowth, or new daughter sacs were treated by individualized approach, using both and surgical techniques.Seventy-five (59.1%) further re-embolization. Standard...
BACKGROUND: Microscope integrated intraoperative near-infrared indocyanine green angiography (ICGA) provides assessment of the cerebral vasculature in operating field. OBJECTIVE: To prospectively compare value ICGA-derived information during aneurysm surgery with data simultaneously generated from other monitoring and vascular imaging techniques. METHODS: Data 104 patients 123 aneurysms who were operated on recorded. Results descriptions how this influenced decision making analyzed. RESULTS:...
Craniopharyngiomas are frequent hypothalamo-pituitary tumors in children, presenting predominantly as cystic lesions. Morbidity from conventional treatment has focused attention on intracystic drug delivery, hypothesized to cause fewer clinical consequences. However, the efficacy of therapy remains unclear. We report retrospective experiences several global centers using interferon-alpha. European Société Internationale d'Oncologie Pédiatrique and International Society for Pediatric...
OBJECTIVE The authors' group recently published a novel technique for navigation-guided frameless stereotactic approach the placement of depth electrodes in epilepsy patients. To improve accuracy trajectory and enhance procedural workflow, authors implemented iSys1 miniature robotic device present study into this routine. METHODS As first step, preclinical phantom was performed using human skull model, timing between 5 implanted with manual aid robot were compared. After showed an increased...
OBJECTIVE Robotic devices have recently been introduced in stereotactic neurosurgery order to overcome the limitations of frame-based and frameless techniques terms accuracy safety. The aim this study is evaluate feasibility novel, miniature, iSYS1 robotic guidance device neurosurgery. METHODS A preclinical phantom trial was conducted compare duration needle positioning between manual technique 162 cadaver biopsies. Second, 25 consecutive cases tumor biopsies intracranial catheter placements...
Conventional antiepileptic drugs suppress the excessive firing of neurons during seizures. In drug-resistant patients, treatment failure indicates an alternative important epileptogenic trigger. Two epilepsy-associated pathologies show myelin deficiencies in seizure-related brain regions: Focal Cortical Dysplasia IIB (FCD) and cortical tubers Tuberous Sclerosis Complex (TSC). Studies uncovering white matter-pathology mechanisms are therefore urgently needed to gain more insight into...
Summary Purpose The current concept for hemispherotomy includes various lateral techniques and the vertical perithalamic introduced by Delalande in 1992. We have chosen approach because of advantages that possibly influence outcome: possibility to completely disconnect hemisphere at level thalamus obviating both need resect insula open dissect subarachnoid space Sylvian fissure. Methods retrospectively analyzed prospectively collected data all patients who underwent Vienna pediatric epilepsy...
Intracranial classic (WHO grade II) and anaplastic III) ependymomas are among the most common tumors in pediatric patients have due to frequent recurrences late relapses a relatively poor outcome. The impact of histopathological grading on patient outcome is controversial therefore, molecular prognostic predictive markers needed improve To date, promising candidate marker chromosome 1q gain, which has been associated independent studies with adverse Furthermore, gene expression methylation...
Choroid plexus tumors are rare entities. Resection is the mainstay of treatment in grade I and II adjuvant usually reserved for less frequent choroid carcinoma (CPC). Outcome not only related to their histological but also dependent on size, location, presence often multifactorial disturbances cerebrospinal fluid (CSF) circulation. Retrospective analysis 36 consecutive patients operated a tumor at our institution mixed pediatric adult population between 1991 2016. Twenty-one CPP, 11 atypical...
Abstract Objective To develop and validate a model to predict seizure freedom in children undergoing cerebral hemispheric surgery for the treatment of drug‐resistant epilepsy. Methods We analyzed 1267 surgeries performed pediatric participants across 32 centers 12 countries identify predictors at 3 months after surgery. A multivariate logistic regression was developed based on 70% dataset (training set) validated 30% (validation set). Missing data were handled using multiple imputation...
This study was undertaken to determine whether the vertical parasagittal approach or lateral peri-insular/peri-Sylvian hemispheric surgery is superior technique in achieving long-term seizure freedom. We conducted a post hoc subgroup analysis of HOPS (Hemispheric Surgery Outcome Prediction Scale) study, an international, multicenter, retrospective cohort that identified predictors freedom through logistic regression modeling. Only patients undergoing parasagittal, peri-insular/peri-Sylvian,...
For microvascular decompression surgery, adequate visualization of the trigeminal nerve root is essential. Several techniques with operating microscopes, endoscopes, a combination both, and exoscopes have been described. In this video, authors use 4K 3D exoscope (ORBEYE) as it offers superb optical image quality high degree magnification illumination in cerebellopontine angle. Other advantages are surgeon ergonomics, very good depth field for entire team, potentially evolving technologies...
The surgical procedure for severe, drug-resistant, unilateral hemispheric epilepsy is challenging. Over the last decades landscape disconnection procedures changed from anatomical hemispherectomy to functional hemispherotomy with a reduction of complications and stable good seizure outcome. Here, task force European surgeons prepared, on behalf EANS Section Functional Neurosurgery, consensus statement different aspects procedure. To determine history, indication, timing, techniques, current...
Abstract Background This study aimed to identify MRI markers predictive of essential surgical characteristics in meningiomas, including consistency, ease dissection meningioma from surrounding brain tissue, and vascularity, which are crucial for decisions outcomes. Methods We conducted preoperative using a standardized protocol measure signal intensities (SI) within meningiomas. Additionally, we administered intraoperative questionnaires performed histological analyses on each tumor. Results...
Augmented reality (AR) is increasingly being used to improve surgical planning and assist in real time procedures. A retrospective investigation was conducted study its feasibility pediatric epilepsy surgery at a single institution. Functional neuronavigation using multimodal imaging data (fMRI, DTI-tractography, PET, SPECT, sEEG) were augment the navigation by transferring MRI reconstructions as AR maps into microscope overlaying field. Altogether, 43 patients (17 female, 0-18 yrs, mean 9...