A5069092257- Multiple Sclerosis Research Studies
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Response and Inflammation
- Peripheral Neuropathies and Disorders
- Polyomavirus and related diseases
- Monoclonal and Polyclonal Antibodies Research
- Tuberous Sclerosis Complex Research
- Cytokine Signaling Pathways and Interactions
- Diabetes and associated disorders
- Systemic Lupus Erythematosus Research
- Epilepsy research and treatment
- Immunodeficiency and Autoimmune Disorders
- Alzheimer's disease research and treatments
- Gut microbiota and health
- Rheumatoid Arthritis Research and Therapies
- Tryptophan and brain disorders
- Cerebrospinal fluid and hydrocephalus
- MicroRNA in disease regulation
- Glioma Diagnosis and Treatment
- Viral gastroenteritis research and epidemiology
- Immune cells in cancer
- Mycobacterium research and diagnosis
Harvard University
2016-2025
Brigham and Women's Hospital
2016-2025
Baylor College of Medicine
2016-2025
Texas Children's Hospital
2016-2025
Massachusetts General Hospital
2009-2025
Mass General Brigham
2024
University of Maryland, College Park
2024
Ottawa Hospital
2023
University of Ottawa
2023
Ottawa Hospital Research Institute
2023
Experimental autoimmune encephalomyelitis (EAE) is a cell-mediated disease that serves as an animal model for multiple sclerosis. Oral administration of myelin basic protein (MBP) suppresses EAE by inducing peripheral tolerance. T cell clones were isolated from the mesenteric lymph nodes SJL mice had been orally tolerized to MBP. These CD4 + and structurally identical helper type 1 (T H 1) encephalitogenic in receptor usage, major histocompatibility complex restriction, epitope recognition....
CD4+CD25+ regulatory T cells contribute to the maintenance of peripheral tolerance by active suppression because their deletion causes spontaneous autoimmune diseases in mice. Human CD4+ expressing high levels CD25 are suppressive vitro and mimic activity murine cells. Multiple sclerosis (MS) is an inflammatory disease thought be mediated recognizing myelin protein peptides. We hypothesized that altered functions CD4+CD25hi play a role breakdown immunologic self-tolerance patients with MS....
BackgroundTuberous sclerosis complex is highly variable in clinical presentation and findings. Disease manifestations continue to develop over the lifetime of an affected individual. Accurate diagnosis fundamental implementation appropriate medical surveillance treatment. Although significant advances have been made past 15 years understanding treatment tuberous complex, current diagnostic criteria not critically evaluated or updated since last consensus conference 1998.MethodsThe 2012...
Abstract The gut microbiome plays an important role in immune function and has been implicated several autoimmune disorders. Here we use 16S rRNA sequencing to investigate the subjects with multiple sclerosis (MS, n =60) healthy controls ( =43). Microbiome alterations MS include increases Methanobrevibacter Akkermansia decreases Butyricimonas , correlate variations expression of genes involved dendritic cell maturation, interferon signalling NF-kB pathways circulating T cells monocytes....
Multiple sclerosis (MS) is a T cell-dependent chronic inflammatory disease of the central nervous system. The role chemokines in MS and its different stages uncertain. Recent data suggest bias expression chemokine receptors by Th1 vs. Th2 cells; human clones express CXCR3 CCR5 CCR3 CCR4. Chemokine expressed cells may be important MS, as increased interferon-gamma (IFN-gamma) precedes clinical attacks, IFN-gamma injection induces exacerbations. We found CXCR3(+) blood relapsing-remitting both...
Original Article from The New England Journal of Medicine — Intensive Immunosuppression in Progressive Multiple Sclerosis A Randomized, Three-Arm Study High-Dose Intravenous Cyclophosphamide, Plasma Exchange, and ACTH
Multiple sclerosis (MS) is considered to be an autoimmune disease of the central nervous system (CNS) that in many patients first presents clinically as optic neuritis. The relationship neuritis MS not well understood. We have generated novel T cell receptor (TCR) transgenic mice specific for myelin oligodendrocyte glycoprotein (MOG). MOG-specific cells are deleted nor tolerized and functionally competent. A large proportion (>30%) TCR spontaneously develop isolated without any...
Tuberous sclerosis complex is a genetic disorder affecting every organ system, but disease manifestations vary significantly among affected individuals. The diverse and varied presentations progression can be life-threatening with significant impact on cost quality of life. Current surveillance management practices are highly variable region country, reflective the fact that last consensus recommendations occurred in 1998 an updated, comprehensive standard lacking incorporates latest...