A5005653232- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Lipid metabolism and disorders
- Cholesterol and Lipid Metabolism
- Lipid metabolism and biosynthesis
- Diet and metabolism studies
- Peroxisome Proliferator-Activated Receptors
- Cancer, Lipids, and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Disease and Adiposity
- Drug Transport and Resistance Mechanisms
- Lipoproteins and Cardiovascular Health
- Cellular transport and secretion
- Fatty Acid Research and Health
- Liver Diseases and Immunity
- Metabolism, Diabetes, and Cancer
- Endoplasmic Reticulum Stress and Disease
- Calcium signaling and nucleotide metabolism
- Diet, Metabolism, and Disease
- Exercise and Physiological Responses
- Lysosomal Storage Disorders Research
- Prenatal Screening and Diagnostics
- Metabolomics and Mass Spectrometry Studies
- Adenosine and Purinergic Signaling
University Medical Center Hamburg-Eppendorf
2016-2025
Universität Hamburg
2016-2025
University of Delhi
2022-2023
University Hospital Ulm
2022-2023
Washington University in St. Louis
2022-2023
Eppendorf (Germany)
1996-2022
Martini-Klinik
1999-2020
Creative Commons
2020
's Heeren Loo
2014-2017
Umeå University
2008
Brown adipose tissue (BAT) combusts high amounts of fatty acids, thereby lowering plasma triglyceride levels and reducing obesity. However, the precise role BAT in cholesterol metabolism atherosclerosis development remains unclear. Here we show that activation by β3-adrenergic receptor stimulation protects from hyperlipidemic APOE*3-Leiden.CETP mice, a well-established model for human-like lipoprotein unlike Apoe(-/-) Ldlr(-/-) mice expresses functional apoE LDLR. increases energy...
Emerging evidence suggests that microbes resident in the human intestine represent a key environmental factor contributing to obesity-associated disorders. Here, we demonstrate gut microbiota-initiated trimethylamine N-oxide (TMAO)-generating pathway is linked obesity and energy metabolism. In multiple clinical cohorts, systemic levels of TMAO were observed strongly associate with type 2 diabetes. addition, circulating associated traits different inbred strains represented Hybrid Mouse...
Brown adipose tissue (BAT) dissipates energy1,2 and promotes cardiometabolic health3. Loss of BAT during obesity ageing is a principal hurdle for BAT-centred therapies, but not much known about apoptosis. Here, untargeted metabolomics demonstrated that apoptotic brown adipocytes release specific pattern metabolites with purine being highly enriched. This secretome enhances expression the thermogenic programme in healthy adipocytes. effect mediated by inosine stimulates energy expenditure...
Abstract Dietary polyunsaturated fatty acids (PUFA) are increasingly recognized for their health benefits, whereas a high production of endogenous – process called de novo lipogenesis (DNL) - is closely linked to metabolic diseases. Determinants PUFA incorporation into complex lipids insufficiently understood and may influence the onset progression Here we show that acid synthase (FASN), key enzyme DNL, critically determines use dietary in mice humans. Moreover, combination FASN inhibition...
Apolipoprotein A5 (APOA5) is associated with differences in triglyceride levels and familial combined hyperlipidemia. In genetically engineered mice, apoAV plasma are inversely correlated triglycerides. To elucidate the mechanism by which influences triglycerides, metabolic studies vitro assays resembling physiological conditions were performed. human APOA5 transgenic mice (hAPOA5tr), catabolism of chylomicrons very low density lipoprotein (VLDL) was accelerated due to a faster hydrolysis...
Abstract Brown adipose tissue (BAT) dissipates energy and its activity correlates with leanness in human adults. 18 F-fluorodeoxyglucose ( F-FDG) positron emission tomography coupled computer (PET/CT) is still the standard for measuring BAT activity, but exposes subjects to ionizing radiation. To study function large cohorts, novel diagnostic tools are needed. Here we show that brown adipocytes release exosomes activation increases exosome release. Profiling miRNAs released from adipocytes,...
Background & AimsIt is well-known that the liver can induce immune tolerance, yet this knowledge could, thus far, not be translated into effective treatments for autoimmune diseases. We have previously shown sinusoidal endothelial cells (LSECs) could substantially contribute to hepatic tolerance through their ability CD4+ Foxp3+ regulatory T (Tregs). Here, we explored whether Treg-inducing potential of LSECs harnessed treatment disease.MethodsWe engineered a polymeric nanoparticle (NP)...
The intracellular transport of cholesterol is subject to tight regulation. structure the lysosomal integral membrane protein type 2 (LIMP-2, also known as SCARB2) reveals a large cavity that traverses molecule and resembles in SR-B1 mediates lipid transfer. detection within LIMP-2 formation cholesterol-like inclusions knockout mice suggested possibility LIMP2 transports lysosomes. We present results molecular modeling, crosslinking studies, microscale thermophoresis cell-based assays support...
Chronic hepatitis B virus (HBV) infection has been associated with alterations in lipid metabolism. Moreover, the Na+-taurocholate cotransporting polypeptide (NTCP), responsible for bile acid (BA) uptake into hepatocytes, was identified as functional cellular receptor mediating HBV entry. The aim of study to determine whether alters liver metabolic profile by employing HBV-infected and uninfected human chimeric mice. Humanized urokinase plasminogen activator/severe combined immunodeficiency...