A5008524903- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Immune cells in cancer
- HIV Research and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Traumatic Brain Injury Research
- Neurological Disease Mechanisms and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Adenosine and Purinergic Signaling
- RNA Interference and Gene Delivery
- Nuclear Receptors and Signaling
- Tryptophan and brain disorders
- RNA Research and Splicing
- Axon Guidance and Neuronal Signaling
- Receptor Mechanisms and Signaling
- S100 Proteins and Annexins
- Cell Adhesion Molecules Research
- Caveolin-1 and cellular processes
- Genetics and Neurodevelopmental Disorders
- Inflammation biomarkers and pathways
- CRISPR and Genetic Engineering
- Circular RNAs in diseases
Boston University
2016-2025
Jacksonville College
2021-2025
Mayo Clinic in Florida
2021-2025
WinnMed
2021-2024
University of Nebraska Medical Center
2004-2023
Google (Israel)
2023
Baidu (China)
2022-2023
Naver (South Korea)
2023
Walter de Gruyter (Germany)
2023
Nashville Oncology Associates
2023
Chronic traumatic encephalopathy is a progressive tauopathy that occurs as consequence of repetitive mild brain injury.We analysed post-mortem brains obtained from cohort 85 subjects with histories injury and found evidence chronic in 68 subjects: all males, ranging age 17 to 98 years (mean 59.5 years), including 64 athletes, 21 military veterans (86% whom were also athletes) one individual who engaged self-injurious head banging behaviour.Eighteen age-and gender-matched individuals without...
Caveolin, a 21-24-kDa integral membrane protein, is principal component of caveolae membranes. We have suggested that caveolin functions as scaffolding protein to organize and concentrate certain caveolin-interacting proteins within In this regard, co-purifies with variety lipid-modified signaling molecules, including G-proteins, Src-like kinases, Ha-Ras, eNOS. Using several independent approaches, it has been shown 20-amino acid proximal region the cytosolic amino-terminal domain sufficient...
Blast exposure is associated with chronic traumatic encephalopathy, impaired neuronal function, and persistent cognitive deficits in blast-exposed military veterans experimental animals.
Abstract Extracellular vesicles are highly transmissible and play critical roles in the propagation of tau pathology, although underlying mechanism remains elusive. Here, for first time, we comprehensively characterized physicochemical structure pathogenic function human brain-derived extracellular isolated from Alzheimer’s disease, prodromal non-demented control cases. disease were significantly enriched epitope-specific oligomers comparison to or as determined by dot blot atomic force...
Abstract Background Recent studies suggest that microglia contribute to tau pathology progression in Alzheimer’s disease. Amyloid plaque accumulation transforms microglia, the primary innate immune cells brain, into neurodegenerative (MGnD), which exhibit enhanced phagocytosis of plaques, apoptotic neurons and dystrophic neurites containing aggregated phosphorylated (p-tau). It remains unclear how promote disease while actively phagocytosing pathological proteins, therefore ameliorating...
Abstract Introduction Extracellular vesicles (EVs) from human Alzheimer's disease (AD) biospecimens contain amyloid beta (Aβ) peptide and tau. While AD EVs are known to affect brain pathobiology, their biochemical molecular characterizations remain ill defined. Methods were isolated the cortical gray matter of 20 18 control brains. Tau Aβ levels measured by immunoassay. Differentially expressed EV proteins assessed quantitative proteomics machine learning. Results Levels pS396 tau Aβ1–42...
In neurodegenerative diseases, extracellular vesicles (EVs) transfer pathogenic molecules and are consequently involved in disease progression. We have investigated the proteomic profiles of EVs that were isolated from four different human-induced pluripotent stem cell-derived neural cell types (excitatory neurons, astrocytes, microglia-like cells, oligodendrocyte-like cells). Novel type-specific EV protein markers then identified for excitatory neurons (ATP1A3, NCAM1), astrocytes (LRP1,...
The p42/44 mitogen‐activated protein (MAP)‐kinase cascade is a well‐established signal transduction pathway that initiated at the cell surface and terminates within nucleus. More specifically, receptor tyrosine kinases can indirectly activate Raf, which in turn leads to activation of MEK ERK ultimately phosphorylation Elk, nuclear transcription factor. Recent reports have suggested some members MAP kinase be sequestered plasmalemmal caveolae vivo. For example, morphological studies directly...
Caveolins-1 and -2 are normally co-expressed, they form a hetero-oligomeric complex in many cell types. These caveolin hetero-oligomers thought to represent the assembly units that drive caveolae formation <i>in vivo</i>. However, functional significance of interaction between caveolins-1 remains unknown. Here, we show caveolin-1 co-expression is required for transport caveolin-2 from Golgi plasma membrane. We identified human erythroleukemic line, K562, expresses but fails express...
Stress induces aggregation of RNA-binding proteins to form inclusions, termed stress granules (SGs). Recent evidence suggests that SG also colocalize with neuropathological structures, but whether this occurs in Alzheimer's disease is unknown. We examined the relationship between and neuropathology brain tissue from P301L Tau transgenic mice, as well cases FTDP-17. The pattern pathology differs dramatically based on protein examined. SGs positive for T-cell intracellular antigen-1 (TIA-1) or...
Cytokines play an emerging role as neurotransmitters, neuromodulators, and neurohormones in the brain. This paradigm shift cytokine function offers a new framework to understand their roles ameliorating neurodegenerative disorders, such Alzheimer's disease (AD). Molecular adjuvant therapy of AD animal models with glatiramer acetate induces antiinflammatory responses therapeutic effects. Although these effects are potentially mediated through anti-inflammatory signaling, exact molecular...
Background: Chronic traumatic encephalopathy (CTE) is a tauopathy associated with prior exposure to repetitive head impacts, such as those incurred through American football and other collision sports.Diagnosis made neuropathological examination.Many of the clinical features CTE are common in general population, without history impact exposure, making diagnosis difficult.As now neurodegenerative disorders, Alzheimer's disease, there need for methods diagnose during life objective...