A5050840947- Neuroinflammation and Neurodegeneration Mechanisms
- Axon Guidance and Neuronal Signaling
- Atherosclerosis and Cardiovascular Diseases
- Immune Response and Inflammation
- Neurogenesis and neuroplasticity mechanisms
- Alzheimer's disease research and treatments
- RNA Research and Splicing
- Nuclear Receptors and Signaling
- Nerve injury and regeneration
Harvard University
2024
Dana-Farber Cancer Institute
2024
Boston University
2017-2020
Neuroinflammatory processes play an integral role in the exacerbation and progression of pathology tauopathies, a class neurodegenerative disease characterized by aggregation hyperphosphorylated tau protein. The RNA binding protein (RBP) T-cell Intracellular Antigen 1 (TIA1) is important regulator innate immune response periphery, dampening cytotoxic inflammation apoptosis during cellular stress, however its neuroinflammation unknown. We have recently shown that TIA1 regulates...
Abstract Sensory neurons generated from induced pluripotent stem cells (iSNs) are used to model human peripheral neuropathies, however current differentiation protocols produce sensory with an embryonic phenotype. Peripheral glial contact early in development and contribute formation of the canonical pseudounipolar morphology, but these signals not encompassed iSN protocols. Here, we show that terminal iSNs co-culture rodent Dorsal Root Ganglion satellite glia (rSG) advances their...