A5077747436- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- Metabolism, Diabetes, and Cancer
- Caveolin-1 and cellular processes
- Pancreatic function and diabetes
- Cardiovascular Disease and Adiposity
- Lipid metabolism and disorders
- Peroxisome Proliferator-Activated Receptors
- Erythrocyte Function and Pathophysiology
- Autophagy in Disease and Therapy
- Trypanosoma species research and implications
- Cancer, Lipids, and Metabolism
- Lipid metabolism and biosynthesis
- Signaling Pathways in Disease
- Diet and metabolism studies
- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- Endoplasmic Reticulum Stress and Disease
- Diabetes and associated disorders
- Liver Disease Diagnosis and Treatment
- Sphingolipid Metabolism and Signaling
- Fibroblast Growth Factor Research
- Biomarkers in Disease Mechanisms
- Biochemical Analysis and Sensing Techniques
The University of Texas Southwestern Medical Center
2016-2025
Southwestern Medical Center
2013-2024
Paracelsus Medical University
2020-2023
Dallas Diabetes Research Center
2011-2021
Medical Cañada (Spain)
2020
RELX Group (United States)
2019
Busan Medical Center
2018
University of Arizona
2018
Dallas Nephrology Associates
2018
Harvard University
2015-2016
We describe a novel 30-kDa secretory protein, Acrp30 (adipocyte complement-related protein of 30 kDa), that is made exclusively in adipocytes and whose mRNA induced over 100-fold during adipocyte differentiation. structurally similar to complement factor C1q hibernation-specific isolated from the plasma Siberian chipmunks; it forms large homo-oligomers undergo series post-translational modifications. Like adipsin, secretion enhanced by insulin, an abundant serum protein. may be participates...
Although excess visceral fat is associated with noninfectious inflammation, it not clear whether simply or actually causes metabolic disease in humans. To evaluate the hypothesis that promotes systemic inflammation by secreting inflammatory adipokines into portal circulation drains fat, we determined adipokine arteriovenous concentration differences across obtaining vein and radial artery blood samples, 25 extremely obese subjects (mean ± SD BMI 54.7 12.6 kg/m2) during gastric bypass surgery...
Excess caloric intake can lead to insulin resistance. The underlying reasons are complex but likely related ectopic lipid deposition in nonadipose tissue. We hypothesized that the inability appropriately expand subcutaneous adipose tissue may be an reason for resistance and β cell failure. Mice lacking leptin while overexpressing adiponectin showed normalized glucose levels dramatically improved as well positively affected serum triglyceride levels. Therefore, modestly increasing of...
Adiponectin is an adipocyte-specific secretory protein that circulates in serum as a hexamer of relatively low molecular weight (LMW) and larger multimeric structure high (HMW). Serum levels the correlate with systemic insulin sensitivity. The full-length affects hepatic gluconeogenesis through improved sensitivity, proteolytic fragment adiponectin stimulates β oxidation muscle. Here, we show ratio, not absolute amounts, between these two oligomeric forms (HMW to LMW) critical determining We...
Acrp30/adiponectin is an adipocyte-specific secretory protein that has recently been implicated as a mediator of systemic insulin sensitivity with liver and muscle target organs. Acrp30 found two forms in serum, lower molecular weight trimer-dimer high complex. Little know about the regulation significance these complexes serum events lead to generation bioactive ligand. Here, we show there profound sexual dimorphism levels complex distribution serum. Female mice display significantly higher...
Adipocytes are embedded in a unique extracellular matrix whose main function is to provide mechanical support, addition participating variety of signaling events. During adipose tissue expansion, the requires remodeling accommodate adipocyte growth. Here, we demonstrate general upregulation several components diabetic state, therefore implicating "adipose fibrosis" as hallmark metabolically challenged adipocytes. Collagen VI highly enriched component tissue. The absence collagen results...
Caveolae are 50-100-nm membrane microdomains that represent a subcompartment of the plasma membrane. Previous morphological studies have implicated caveolae in (a) transcytosis macromolecules (including LDL and modified LDLs) across capillary endothelial cells, (b) uptake small molecules via process termed potocytosis involving GPI-linked receptor an unknown anion transport protein, (c) interactions with actin-based cytoskeleton, (d) compartmentalization certain signaling molecules,...
Intraperitoneal injection of purified recombinant Acrp30 lowers glucose levels in mice. To gain insight into the mechanism(s) this hypoglycemic effect, was infused conscious mice during a pancreatic euglycemic clamp. In presence physiological hyperinsulinemia, treatment increased circulating by approximately twofold and stimulated metabolism. The effect on vivo insulin action completely accounted for 65% reduction rate production. Similarly, flux through glucose-6-phosphatase (G6Pase)...
Scavenger receptors are integral membrane proteins that mediate the endocytosis of modified lipoproteins. The first these to be purified and cloned were type I II macrophage scavenger (SR-AI SR-AII; class A receptors). Subsequently, cell surface protein CD36 was shown bind oxidized low density lipoprotein (oxidized LDL). From a Chinese hamster ovary (CHO) variant we have by expression cDNA for new member family proteins, SR-BI, whose predicted sequence 509 amino acids is approximately 30%...
Adipose tissue can undergo rapid expansion during times of excess caloric intake. Like a rapidly expanding tumor mass, obese adipose becomes hypoxic due to the inability vasculature keep pace with growth. Consequently, early stages obesity, conditions cause an increase in level hypoxia-inducible factor 1alpha (HIF1alpha) expression. Using transgenic model overexpression constitutively active form HIF1alpha, we determined that HIF1alpha fails induce expected proangiogenic response. In...