A5030757026- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Sphingolipid Metabolism and Signaling
- Pancreatic function and diabetes
- Cancer Risks and Factors
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer, Lipids, and Metabolism
- Regulation of Appetite and Obesity
- Lipid metabolism and biosynthesis
- Peroxisome Proliferator-Activated Receptors
- Island Studies and Pacific Affairs
- Diabetes Treatment and Management
- Nutrition and Health in Aging
- Lipid Membrane Structure and Behavior
- Mitochondrial Function and Pathology
- Lipid metabolism and disorders
- Diet, Metabolism, and Disease
- Diabetes and associated disorders
- Cancer, Hypoxia, and Metabolism
- Fibroblast Growth Factor Research
- Diabetes Management and Research
- Diet and metabolism studies
- Cholesterol and Lipid Metabolism
- Endoplasmic Reticulum Stress and Disease
- Eicosanoids and Hypertension Pharmacology
University of Utah
2009-2025
Sheffield Teaching Hospitals NHS Foundation Trust
2022-2023
Robert Wood Johnson Foundation
2022
Yale New Haven Hospital
2022
Royal Hallamshire Hospital
2022
The University of Texas Southwestern Medical Center
2011-2021
University of Utah Health Care
2020
Southwestern Medical Center
2010-2018
Touchstone Research Laboratory (United States)
2014-2017
London School of Economics and Political Science
2005-2015
Obesity is associated with an enhanced inflammatory response that exacerbates insulin resistance and contributes to diabetes, atherosclerosis, cardiovascular disease. One mechanism accounting for the increased inflammation obesity activation of innate immune signaling pathway triggered by TLR4 recognition saturated fatty acids, event essential lipid-induced resistance. Using in vitro vivo systems model lipid induction TLR4-dependent events rodents, we show here upstream component required...
Ceramides in focus Excess calorie intake can ultimately lead to a metabolic syndrome that interferes with fat or lipid metabolism. There are many different types of lipids, and it has been widely debated which the true culprits underlying disorders. Chaurasia et al. report ceramides major contributor insulin resistance fatty liver disease (see Perspective by Kusminski Scherer). This appears be caused enzyme dihydroceramide desaturase 1 (DES1), is normally involved ceramide production...
Insulin signaling can be modulated by several isoforms of PKC in peripheral tissues. Here, we assessed whether one specific isoform, PKC-theta, was expressed critical CNS regions that regulate energy balance and it mediated the deleterious effects diets high fat, specifically palmitic acid, on hypothalamic insulin activity rats mice. Using a combination situ hybridization immunohistochemistry, found PKC-theta discrete neuronal populations arcuate nucleus, neuropeptide Y/agouti-related...
Parathyroid extract (PTE) had neither calcemic nor phosphaturic effects in 8 alcoholic patients who both hypocalcemia and hypomagnesemia. Correction of the hypomagnesemia by intravenous infusion magnesium sulfate for 3 days resulted disappearance PTE refractoriness correction serum calcium. Two additional hypomagnesemic alcoholics remained refractory to during treatment with multivitamin supplements including large amounts vitamin D, but they responded briskly following One non-alcoholic...
BACKGROUND. Ceramides are sphingolipids that play causative roles in diabetes and heart disease, with their serum levels measured clinically as biomarkers of cardiovascular disease (CVD).
Abstract Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent genetic cause of renal failure. Here we identify miR-17 as a target for treatment ADPKD. We report that induced in cysts mouse and human Genetic deletion miR-17∼92 cluster inhibits cyst proliferation PKD progression four orthologous, including two long-lived, models Anti-miR-17 attenuates growth short-term long-term models. inhibition also suppresses primary ADPKD cultures derived from multiple donors....
Aging results in an elevated burden of senescent cells, senescence-associated secretory phenotype (SASP), and tissue infiltration immune cells contributing to chronic low-grade inflammation a host age-related diseases. Recent evidence suggests that the clearance alleviates its associated dysfunction However, effect this intervention on metabolic function old age remains poorly understood. Here, we demonstrate dasatinib quercetin (D&Q) have senolytic effects, reducing increase...
Recent studies indicate that insulin resistance and type 2 diabetes result from the accumulation of lipids in tissues not suited for fat storage, such as skeletal muscle liver. To elucidate mechanisms linking exogenous fats to inhibition action, we evaluated effects free fatty acids (FFAs) on signal transduction cultured C2C12 myotubes. As described previously (Chavez, J. A., Summers, S. A. (2003) Arch. Biochem. Biophys. 419, 101-109), long-chain saturated FFAs inhibited stimulation...
Vascular dysfunction that accompanies obesity and insulin resistance may be mediated by lipid metabolites. We sought to determine if vascular ceramide leads arterial elucidate the underlying mechanisms. Pharmacological inhibition of de novo synthesis, using Ser palmitoyl transferase inhibitor myriocin, heterozygous deletion dihydroceramide desaturase prevented hypertension in mice after high-fat feeding. These findings were recapitulated isolated arteries vitro, confirming impairs...
Adiponectin and the signaling induced by its cognate receptors, AdipoR1 AdipoR2, have garnered attention for their ability to promote insulin sensitivity oppose steatosis. Activation of these receptors promotes deacylation ceramide, a lipid metabolite that appears play causal role in impairing signaling. Here, we developed transgenic mice overexpress or AdipoR2 under inducible control tetracycline response element. These represent first genetic models acutely manipulate adiponectin receptor...