A5007183394- Telomeres, Telomerase, and Senescence
- Cardiovascular Health and Disease Prevention
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Single-cell and spatial transcriptomics
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Advanced Fluorescence Microscopy Techniques
- Metabolism, Diabetes, and Cancer
- Circadian rhythm and melatonin
- Genetics, Aging, and Longevity in Model Organisms
- Calcium signaling and nucleotide metabolism
- Cell Image Analysis Techniques
- Cancer, Hypoxia, and Metabolism
- Nitric Oxide and Endothelin Effects
- Advanced biosensing and bioanalysis techniques
- Legume Nitrogen Fixing Symbiosis
- Antioxidant Activity and Oxidative Stress
- Pancreatic function and diabetes
- Dietary Effects on Health
- Atherosclerosis and Cardiovascular Diseases
- Poverty, Education, and Child Welfare
- Immune Cell Function and Interaction
- Climate Change, Adaptation, Migration
- Nanomaterials for catalytic reactions
Oak Ridge National Laboratory
2024-2025
The University of Texas Southwestern Medical Center
2024-2025
Southwestern Medical Center
2024-2025
University of Utah
2019-2024
University of Rajshahi
2023
University of Nebraska–Lincoln
2017-2021
University of Dhaka
2015-2021
Jahangirnagar University
2020-2021
Dhaka National Medical College
2019
Dhaka Medical College and Hospital
2019
Aging results in an elevated burden of senescent cells, senescence-associated secretory phenotype (SASP), and tissue infiltration immune cells contributing to chronic low-grade inflammation a host age-related diseases. Recent evidence suggests that the clearance alleviates its associated dysfunction However, effect this intervention on metabolic function old age remains poorly understood. Here, we demonstrate dasatinib quercetin (D&Q) have senolytic effects, reducing increase...
Abstract In advanced age, increases in oxidative stress and inflammation impair endothelial function, which contributes to the development of cardiovascular disease (CVD). One plausible source this is an increase abundance senescent cells. Cellular senescence a cell cycle arrest that occurs response various damaging stimuli. present study, we tested hypothesis age results telomere dysfunction induces senescence. both human mouse cells, resulted increased dysfunctional telomeres,...
Plants are complex systems hierarchically organized and composed of various cell types. To understand the molecular underpinnings plant systems, single-cell RNA sequencing (scRNA-seq) has emerged as a powerful tool for revealing high resolution gene expression patterns at cellular level investigating cell-type heterogeneity. Furthermore, scRNA-seq analysis biosystems great potential generating new knowledge to inform design synthetic biology, which aims modify plants...
Abstract Intermittent fasting (IF) is associated with enormous metabolic alterations that underpin its diverse health effects. Changes in lipid metabolism, particularly ceramides, and other sphingolipids, are among the most notable of these alterations. This study investigated lipidomic 29–30 days Ramadan diurnal intermittent (RIF) metabolically healthy overweight obese subjects. A prospective cohort 57 adults (70% males, 38.4 ± 11.2 years), an age range 18–58 years was observed prior to at...
Gene stacking, the process of introducing multiple genes into a single plant to enhance desired traits, is essential for genetic improvement through both conventional breeding and transformation. In general, transformation-based gene stacking can be achieved either co-transformation simultaneously introduce or sequential multi-round While generally faster more efficient than transformation, it often requires two selectable marker genes, which confer resistance antibiotics, selecting...
Understanding how subcellular structures and events shape tissue-wide phenomena remains a central challenge in biology. We present Multiscale Cleared Tissue Axially Swept Light-Sheet Microscopy (MCT-ASLM), platform combining cm-scale imaging with targeted high-resolution interrogation of intact tissues human-guided or autonomous modes. Capable capturing fields view up to 21 mm at micron-scale resolution, MCT-ASLM can seamlessly transition submicron (~300 nm) isotropic resolution for imaging....
Summary RNA plays a central role in plants, governing various cellular and physiological processes. Monitoring its dynamic abundance provides discerning understanding of molecular mechanisms underlying plant responses to internal (developmental) external (environmental) stimuli, paving the way for advances biotechnology engineer crops with improved resilience, quality productivity. In general, traditional methods analysis plants require destructive, labour‐intensive time‐consuming assays. To...
Advanced age is accompanied by aortic stiffening that associated with decreased vascular expression of sirtuin-1 (SIRT-1).Interventions increase SIRT-1 also lower age-related stiffness.Therefore, we sought to determine if lifelong overexpression would attenuate stiffening.Aortic pulse wave velocity (PWV) was assessed from 3-24 months in transgenic overexpressing (SIRT TG ) and wildtype (WT) mice.To the role structural changes on stiffening, histological assessment wall characteristics...
Abstract Systemic inhibition of the mammalian target rapamycin (mTOR) delays aging and many age‐related conditions including arterial metabolic dysfunction. However, mechanisms tissues involved in these beneficial effects remain largely unknown. Here, we demonstrate that activation S6K, a downstream mTOR, is increased arteries with advancing age, this occurs preferentially endothelium compared vascular smooth muscle. Induced endothelial cell‐specific deletion mTOR reduced protein expression...
Much of what we know about insulin resistance is based on studies from metabolically active tissues such as the liver, adipose tissue, and skeletal muscle. Emerging evidence suggests that vascular endothelium plays a crucial role in systemic resistance; however, underlying mechanisms remain incompletely understood. Arf6 (ADP ribosylation factor 6) small GTPase critical endothelial cell function. Here, tested hypothesis deletion will result resistance.
Cell segmentation is the fundamental task. Only by segmenting, can we define quantitative spatial unit for collecting measurements to draw biological conclusions. Deep learning has revolutionized 2D cell segmentation, enabling generalized solutions across types and imaging modalities. This been driven ease of scaling up image acquisition, annotation computation. However 3D which requires dense slices still poses significant challenges. Labelling every in slice prohibitive. Moreover it...
Atherogenic remodeling often occurs at arterial locations with disturbed blood flow (i.e., low or oscillatory) and both aging western diet (WD) increase the likelihood for pro-atherogenic remodeling. However, it is unknown if old age and/or a WD modify response to flow. We induced by partial carotid ligation (PCL) of left artery in young old, normal chow (NC) fed male B6D2F1 mice. Three weeks post-PCL, ligated arteries had greater intima media thickness, neointima formation, macrophage...
Titanium dioxide (TiO2) nanoparticles have been extensively studied for catalyzing the photo-degradation of organic pollutants, photocatalyst being nonselective to substrate. We, however, found that TiO2 prepared via sol-gel and hydrothermal synthetic routes each possess a definite specificity charge substrate photodegradation. The were characterized by SEM, FTIR, XRD, TGA, UV-visible spectra, photocatalytic degradation under UV-B (285 nm) irradiation two model compounds, anionic methyl...
<title>Abstract</title> Bangladesh, as a populous South Asian nation, grapples with the dual challenge of meeting escalating energy demands while tackling environmental degradation and reducing dependency on fossil fuels. In response to imperative sustainable development pressing global issue climate change, adoption renewable sources has emerged critical strategy. This paper explores viability potential solar photovoltaic (PV) power plants solution Bangladesh’s challenges, specific focus...
IntroductionTragia involucrata L. have been utilized as traditional medicine in Indian subcontinent for the treatment of numerous illnesses such inflammation, pain and skin infection. In this current study we sought to assess anxiolytic, sedative analgesic activity Tragia leaves extract.Materials methodsWe first performed a phytochemical screening test extracts following standard protocols. We next examined anxiolytic crude methanol (TIME), ethyl acetate (TIEAE) n-Hexane (TIHE) extract using...
Zika virus (ZIKV) infection in pregnancy is associated with the development of microcephaly, intrauterine growth restriction, and ocular damage fetus. ZIKV placenta plays a crucial role vertical transmission from maternal circulation to Our previous study suggested that induces endoplasmic reticulum (ER) stress apoptosis placental trophoblasts. Here, we showed palmitoleate, an omega-7 monounsaturated fatty acid, prevents ZIKV-induced ER Human trophoblast cell lines (JEG-3 JAR) normal...
Atherosclerosis is the root cause of major cardiovascular diseases (CVD) such as myocardial infarction and stroke. ADP-ribosylation factor 6 (Arf6) a ubiquitously expressed GTPase known to be involved in inflammation, vascular permeability sensitive changes shear stress. Here, using atheroprone, ApoE -/- mice, with single allele deletion Arf6 (HET) or wildtype (WT), we demonstrate that reduction attenuates atherosclerotic plaque burden severity. We found descending aorta was lower HET...