A5072061963- Cardiovascular Health and Disease Prevention
- Cerebrovascular and Carotid Artery Diseases
- Nitric Oxide and Endothelin Effects
- Cardiovascular Disease and Adiposity
- Blood Pressure and Hypertension Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Neurological Disease Mechanisms and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Telomeres, Telomerase, and Senescence
- Adipose Tissue and Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Menopause: Health Impacts and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Genetics, Aging, and Longevity in Model Organisms
- Neurological Disorders and Treatments
- Schizophrenia research and treatment
- Frailty in Older Adults
- Heart Rate Variability and Autonomic Control
- Dementia and Cognitive Impairment Research
- Origins and Evolution of Life
- Mental Health and Psychiatry
- Vitamin D Research Studies
- Antioxidant Activity and Oxidative Stress
- Cardiovascular Function and Risk Factors
- Innovations in Medical Education
University of Oregon
2018-2024
University of Utah
2012-2023
University of Tennessee Health Science Center
2023
Walker (United States)
2010-2023
University of Oklahoma
2013-2022
Monash University
2011-2019
University of Tulsa
2019
Geriatric Research Education and Clinical Center
2014-2018
Georgia Southern University
2011-2016
University of Colorado Boulder
2007-2015
We tested the hypothesis that vascular endothelial function, assessed by endothelium-dependent dilation, is related to serum vitamin D status among middle-aged and older adults without clinical disease, this linked inflammation. Brachial artery flow-mediated a measure of was lower (P<0.01) in D-insufficient (3.7 ± 0.2%; 25-hydroxyvitamin [25(OH)D]: 20 29 ng/mL; 62 1 years age; n = 31; mean± SE) D-deficient (3.2 0.3%; 25(OH)D: <20 63 2 22) versus D-sufficient (4.6 0.4%; >29 61 subjects,...
Brachial artery FMD (flow-mediated dilation) is impaired with aging and associated an increased risk of CVD (cardiovascular disease). In the present study, we determined whether regular aerobic exercise improves brachial in MA/O (middle-aged/older) men post-menopausal women. sedentary adults (age, 55–79 years) without CVD, 8 weeks brisk walking (6 days/week for approx. 50 min/day; randomized controlled design) treadmill time 20% both (n=11) women (n=15) (P&lt;0.01), altering body...
Background— Cerebral cavernous malformation (CCM) is a hemorrhagic stroke disease affecting up to 0.5% of North Americans that has no approved nonsurgical treatment. A subset patients have hereditary form the due primarily loss-of-function mutations in KRIT1, CCM2 , or PDCD10. We sought identify known drugs could be repurposed treat CCM. Methods and Results— developed an unbiased screening platform based on both cellular animal models loss function . Our discovery strategy consisted 4 steps:...
Aging impairs arterial function through oxidative stress and diminished nitric oxide (NO) bioavailability. Life-long caloric restriction (CR) reduces stress, but its impact on aging is incompletely understood. We tested the hypothesis that life-long CR attenuates key features of aging. Blood pressure, pulse wave velocity (PWV, stiffness), carotid artery wall thickness endothelium-dependent dilation (EDD; endothelial function) were assessed in young (Y: 5–7 month), old ad libitum (Old AL:...
Summary Inhibition of mammalian target rapamycin, mTOR , extends lifespan and reduces age‐related disease. It is not known what role plays in the arterial aging phenotype or if inhibition by dietary rapamycin ameliorates dysfunction. To explore this, young (3.8 ± 0.6 months) old (30.3 0.2 male B6D2F1 mice were fed a supplemented control diet for 6–8 weeks. Although there few other notable changes animal characteristics after treatment, we found that glucose tolerance improved mice, but was...
The phosphodiesterase 5A inhibitor tadalafil restores normal blood flow regulation in exercising skeletal muscle of patients with Becker muscular dystrophy.
Vitamin D is a known modulator of inflammation. Native dietary vitamin D3 thought to be bio-inactive, and beneficial effects are largely mediated by the metabolite 1,25(OH)2D3. Reduced serum levels most commonly measured precursor metabolite, 25(OH)D3, linked an increased risk multiple inflammatory diseases, including: cardiovascular disease, arthritis, sclerosis, sepsis. Common all these diseases disruption endothelial stability enhancement vascular leak. We previously performed unbiased...
Habitual aerobic exercise prevents age-related impairments in endothelium-dependent dilation (EDD). We have hypothesized that the pro-inflammatory transcription factor nuclear κB (NF-κB) impairs EDD with sedentary aging, and habitual this suppression of by NF-κB. To test hypothesis, we inhibited NF-κB signalling via oral salsalate administration healthy older exercise-trained adults (OT, n=14, 58 ± 2 years), non-exercising (ON, n=16, 61 1 years) young controls (YN, n=8, 23 years). Salsalate...
Vascular endothelial dysfunction develops with aging, as indicated by impaired endothelium-dependent dilation, and is related to increased cardiovascular disease risk. We hypothesized that short-term treatment fenofibrate, a lipid-lowering agent potential pleiotropic effects, would improve dilation in middle-aged older normolipidemic adults reducing oxidative stress. Brachial artery flow-mediated measure of was assessed 22 healthy aged 50 77 years before after 7 days fenofibrate (145 mg/d;...
The critical influence of the white adipose tissue (WAT) on metabolism is well-appreciated in obesity, but dysfunction as a mechanism underlying age-associated metabolic requires elucidation. To explore this possibility, we assessed and measures epididymal (e)WAT mitochondria artery function young (6.1 ± 0.4 months) old (29.6 0.2 B6D2F1 mice. There were no group differences average daily oxygen consumption, fasted blood glucose or plasma free fatty acids, insulin homeostatic model assessment...
Telomere shortening in arteries could lead to telomere uncapping and cellular senescence, which turn promote the development of hypertension.To assess novel role arterial dysfunction hypertension, we compared mean length (qPCR), (serine 139 phosphorylated histone γ-H2A.X (γ-H2) localized telomeres: ChIP), tumor suppressor protein p53 (P53)/cyclin-dependent kinase inhibitor 1A (P21)-induced senescence (P53 bound P21 gene promoter: ChIP) from 55 age-matched hypertensive nonhypertensive...
In the present study, we tested hypothesis that age-associated vascular endothelial dysfunction is exacerbated by IFG (impaired fasting plasma glucose) and regular aerobic exercise prevents this effect. Data were analysed from a cohort of 131 non-smoking men women without overt clinical disease. Compared with young adult controls (age=24±1 years, n=29; values are means±S.E.M.), brachial artery FMD (flow-mediated dilation), measure conduit EDD (endothelium-dependent was 33% lower [7.93±0.33...
Increased large artery stiffness is a hallmark of arterial dysfunction with advancing age and also present in other disease conditions such as diabetes. correlated resistance humans. Using mouse model altered elastin content, this the first study to examine cause-and-effect relationship between peripheral function. Our results indicate that mice genetically greater have impaired cerebral endothelial function, but generally preserved skeletal muscle feed The mechanisms for function are...
Objective: Aortic pulse-wave velocity (aPWV) increases with age and is a strong independent predictor of incident cardiovascular diseases (CVDs) in healthy middle-aged older adults. aPWV lower adults who perform regular aerobic exercise than their sedentary peers. As associated reduced systemic inflammation, we hypothesized that suppression the pro-inflammatory transcription factor nuclear κ B (NFκB) may mediate this process. Methods: was measured young [n = 10, blood pressure (BP) 108 ±...
Vascular aging is characterized by a tandem increase in pulse pressure and large elastic artery stiffness. Greater stiffness of the arteries leads to elevated transmitted into cerebral circulation, causing dysfunction. However, little known females about age-related stiffening impacts high on vasculature. To examine effects sex age response pressure, we studied collected from young old female male C57BL/6 mice. Isolated were exposed ex vivo static low pressure. Exposure impaired...
Aging is associated with reduced endothelium-dependent dilation (EDD) and increased risk for cardiovascular disease (CVD), but the mechanisms are incompletely understood. Clinically elevated plasma low-density lipoprotein cholesterol (LDL-C) impaired EDD. The purpose of this study was to determine whether circulating LDL-C within "normal" range modulates EDD in healthy older adults young age or habitual aerobic exercise protects against adverse effect.In 83 men optimal/near optimal (<130...
Endothelium-dependent dilation (EDD) is impaired with aging, but there significant variability among healthy middle-aged and older adults. We tested the hypothesis that EDD related to white blood cell (WBC) count in men women aged 55 75 years (n=48) who have a WBC within clinically normal range. The peak forearm flow response intrabrachial artery infusion of acetylcholine was inversely (r=-0.38; P=0.004) 34% smaller subjects higher versus lower (more less than median 5.0x10(9) cells per...