A5034221747- Cardiovascular Health and Disease Prevention
- Pregnancy and preeclampsia studies
- Blood Pressure and Hypertension Studies
- Birth, Development, and Health
- Cardiovascular Disease and Adiposity
- Heart Rate Variability and Autonomic Control
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular and exercise physiology
- Nitric Oxide and Endothelin Effects
- Cardiovascular Function and Risk Factors
- Electrolyte and hormonal disorders
- Cardiovascular Issues in Pregnancy
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Reproductive System and Pregnancy
- Cardiovascular Health and Risk Factors
- Cardiac Health and Mental Health
- Transplantation: Methods and Outcomes
- Non-Invasive Vital Sign Monitoring
- Atherosclerosis and Cardiovascular Diseases
- Thermoregulation and physiological responses
- Gestational Diabetes Research and Management
- Maternal and fetal healthcare
- Adipokines, Inflammation, and Metabolic Diseases
- Antioxidant Activity and Oxidative Stress
- Chronic Obstructive Pulmonary Disease (COPD) Research
University of Iowa
2016-2025
Health and Human Development (2HD) Research Network
2008-2024
Fraternal Order of Eagles
2014-2022
Cardiovascular Research Center
2018-2019
Diabetes Research Center
2019
University of Iowa Health Care
2018
University of Iowa Hospitals and Clinics
2018
Iowa Diabetes and Endocrinology Research Center
2017-2018
Hypertension Institute
2018
Augusta University
2010-2016
Aging is associated with impaired vascular endothelial function, as indicated in part by reduced endothelium-dependent dilation (EDD). Decreased EDD aging thought to be related cell oxidative stress, but direct evidence lacking. We studied 95 healthy men: 51 young (23±1 years) and 44 older (63±1 years). (brachial artery flow-mediated dilation) was ≈50% lower versus men (3.9±0.3% 7.6±0.3%, P <0.01; n=42 older/n=51 young). Abundance of nitrotyrosine (quantitative immunofluorescence), an...
We tested the hypothesis that vascular endothelial function, assessed by endothelium-dependent dilation, is related to serum vitamin D status among middle-aged and older adults without clinical disease, this linked inflammation. Brachial artery flow-mediated a measure of was lower (P<0.01) in D-insufficient (3.7 ± 0.2%; 25-hydroxyvitamin [25(OH)D]: 20 29 ng/mL; 62 1 years age; n = 31; mean± SE) D-deficient (3.2 0.3%; 25(OH)D: <20 63 2 22) versus D-sufficient (4.6 0.4%; >29 61 subjects,...
Key points Advancing age is the major risk factor for development of cardiovascular diseases. Arterial endothelial dysfunction, characterized by impaired endothelium‐dependent dilatation (EDD), a key antecedent to age‐associated clinical disease. We tested hypothesis that changes in autophagy, process which cells recycle damaged biomolecules, may be an underlying cause age‐related reduction EDD. show autophagy arteries older humans and mice with reduced EDD, enhancing restores EDD reducing...
Cellular senescence is emerging as a key mechanism of age-related vascular endothelial dysfunction, but evidence in healthy humans lacking. Moreover, the influence lifestyle factors such habitual exercise on cell (EC) unknown. We tested hypothesis that EC increases with sedentary, not physically active, aging and associated dysfunction. Protein expression (quantitative immunofluorescence) p53, transcription factor related to increased cellular senescence, cyclin-dependent kinase inhibitors...
A total of 1,537 clinical isolates Haemophilus influenzae were recovered in 30 U.S. medical center laboratories between 1 November 1994 and April 1995 characterized a central laboratory with respect to serotype beta-lactamase production the vitro activities 15 oral antimicrobial agents. Overall, 36.4% found produce beta-lactamase. The rank order activity six cephalosporins on basis MICs was cefixime > cefpodoxime cefuroxime loracarbef or = cefaclor cefprozil. On current National Committee...
Vitamin D insufficiency/deficiency is commonly observed in black youth.The aim was to determine 25-hydroxyvitamin [25(OH)D] response 2000 IU vitamin supplementation over time; evaluate the relation between 25(OH)D concentrations and total body fat mass by dual-energy x-ray absorptiometry; whether improves arterial stiffness measured pulse wave velocity (PWV).We conducted a randomized, blinded, controlled clinical trial.Forty-nine normotensive boys girls, aged 16.3 ± 1.4 yr, were randomly...
We tested the hypothesis that nuclear factor-kappaB (NF-kappaB) activity contributes to vascular endothelial dysfunction with aging and obesity in humans.We conducted a randomized, double-blind, placebo-controlled crossover study 14 nondiabetic overweight or obese (body mass index > =25 kg/m(2)) middle-aged older (age 52 68 years) adults. Salsalate (nonacetylated salicylate, 4500 mg/d), compound inhibits NF-kappaB activity, placebo was administered for 4-day periods. Plasma salicylate...
The effect of moderate left ventricular systolic dysfunction (LVSD) on ventricular/vascular coupling and the aortic pressure waveform (AoPW) has been well described, but severe LVSD not.We used noninvasive, high-fidelity tonometry radial artery a mathematical transfer function to generate AoPW in 25 treated patients with (mean LV ejection fraction, 24+/-8.8%; range, 11% 40%; 21 <30%). Pulse wave analysis was characterize compared pulse performed normal subjects matched for age, gender,...
Brachial artery FMD (flow-mediated dilation) is impaired with aging and associated an increased risk of CVD (cardiovascular disease). In the present study, we determined whether regular aerobic exercise improves brachial in MA/O (middle-aged/older) men post-menopausal women. sedentary adults (age, 55–79 years) without CVD, 8 weeks brisk walking (6 days/week for approx. 50 min/day; randomized controlled design) treadmill time 20% both (n=11) women (n=15) (P&lt;0.01), altering body...
Obesity is associated with vascular endothelial dysfunction, as indicated by impaired endothelium-dependent dilation. Presently there no direct evidence that energy intake-restricted weight loss alone improves conduit or resistance artery dilation, the mechanisms involved, whether improvements differ patient age. A total of 40 overweight obese (body mass index: >or=25<40 kg/m(2)) nondiabetic men and women aged 21 to 69 years completed 12 weeks reduced intake (n=26; 15 male) attention control...
We tested the hypothesis that older men who perform habitual aerobic exercise do not demonstrate age-associated vascular endothelial oxidative stress compared with their sedentary peers. Older exercising (n=13, 62±2 years) had higher (P<0.05) physical activity (79±7 vs. 30±6 MET hours per week) and maximal oxygen consumption (42±1 29±1 mL kg(-1) minute) (n=28, 63±1 years). Brachial artery flow-mediated dilation (FMD), a measure of function, was greater in (6.3±0.5 4.9±0.4%Δ) different than...
Although there is promising evidence that regular physical activity could counteract age-related decline in cognitive and brain function, the mechanisms for this neuroprotection remain unclear. The acute effects of exercise can provide insight into by which adapts to habitual reflecting transient modulations systems would subsequently accumulate long-term adaptations through repeated training sessions. However, methodological limitations have hindered mechanistic gained from previous studies...
Muscle sympathetic nerve activity (MSNA) influences the mechanical properties (ie, vascular smooth muscle tone and stiffness) of peripheral arteries, but it remains controversial whether MSNA contributes to stiffness central such as aorta carotids. We examined elevated (age-related) would be independently associated with greater (carotid-femoral pulse wave velocity [PWV]) (carotid-brachial PWV) in addition lower carotid compliance coefficient, healthy men women (n=88, age: 19-73 years, 52%...
ABSTRACT Purpose Previous studies report memory and functional connectivity of systems improve acutely after a single aerobic exercise session or with training, suggesting that the acute effects may reflect initial changes adapt over time. In this trial, for first time, we test proof-of-concept whether training on working brain network are related in same participants. Methods Cognitively normal older participants ( N = 34) were enrolled randomized clinical trial (NCT02453178). Participants...
Arterial stiffness, as measured by arterial pulse wave velocity (PWV), is an established biomarker for cardiovascular risk and target-organ damage in individuals with hypertension. With the emergence of new devices assessing PWV, it has become evident that some these yield results display significant discrepancies compared previous devices. This discrepancy underscores importance comprehensive validation procedures need international recommendations.
OBJECTIVE—To determine if children with type 1 diabetes have increased arterial stiffness by estimating augmentation index the simple noninvasive technique of radial artery tonometry. RESEARCH DESIGN AND METHODS—We studied 98 diabetic and 57 healthy control subjects, ages 10–18 years, matched for age, sex, race, BMI, generating 43 pairs. Radial tonometry was performed, blood collected analysis fasting lipids, HbA1c, glucose, cytokines in all children. RESULTS—Children had a significantly...
To increase understanding about the effects of moderate-intensity physical activity on cognitive function, current study examined whether a single bout aerobic exercise exerts differential distinct aspects executive function in healthy young adults.A within-subjects was designed where 26 adult participants (mean age = 25.23 yr, 12 males) engaged 30-min both (a) cycling and (b) passive motor-driven cycling, occurring two separate occasions counterbalanced their order. assess changes...
Inflammation may play an important role in the formation and rupture of cerebral aneurysms. Chemokines act as chemoattractants for leukocytes directing them toward sites tissue inflammation. The purpose this study was to determine whether chemokines chemoattractant cytokines were increased lumen human aneurysms.The concentrations other inflammatory molecules blood samples drawn from aneurysms 16 consecutive patients (harboring 18 aneurysms) compared with femoral arteries same patients. Three...
Habitual aerobic exercise prevents age-related impairments in endothelium-dependent dilation (EDD). We have hypothesized that the pro-inflammatory transcription factor nuclear κB (NF-κB) impairs EDD with sedentary aging, and habitual this suppression of by NF-κB. To test hypothesis, we inhibited NF-κB signalling via oral salsalate administration healthy older exercise-trained adults (OT, n=14, 58 ± 2 years), non-exercising (ON, n=16, 61 1 years) young controls (YN, n=8, 23 years). Salsalate...
Copeptin, a marker of arginine vasopressin (AVP) secretion, is elevated throughout human pregnancies complicated by preeclampsia (PE), and AVP infusion gestation sufficient to induce the major phenotypes PE in mice. Thus, we hypothesized role for pathogenesis PE. into pregnant C57BL/6J mice resulted hypertension, renal glomerular endotheliosis, intrauterine growth restriction, decreased placental factor (PGF), altered morphology, oxidative stress, gene expression consistent with...
Aging causes micro- and macrovascular endothelial dysfunction, as assessed by endothelium-dependent dilation (EDD), which can be prevented reversed habitual aerobic exercise (AE) in men. However, estrogen-deficient postmenopausal women, whole forearm microvascular EDD has not been studied, a beneficial effect of AE on consistently shown. We blood flow response to brachial artery infusions acetylcholine (FBF ACh ), measure EDD, flow-mediated (FMD), 12 premenopausal sedentary women (Pre-S; 24...