Pascal Jabbour
A5061484429- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Vascular Malformations Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Venous Thromboembolism Diagnosis and Management
- Neurosurgical Procedures and Complications
- Stroke Rehabilitation and Recovery
- Vascular Procedures and Complications
- Moyamoya disease diagnosis and treatment
- Peripheral Artery Disease Management
- Ocular Oncology and Treatments
- Meningioma and schwannoma management
- Central Venous Catheters and Hemodialysis
- Cerebrospinal fluid and hydrocephalus
- Aortic aneurysm repair treatments
- Brain Metastases and Treatment
- Cerebral Venous Sinus Thrombosis
- Long-Term Effects of COVID-19
- Cardiovascular Health and Disease Prevention
- Spinal Fractures and Fixation Techniques
- COVID-19 and healthcare impacts
- Glioma Diagnosis and Treatment
- Aortic Disease and Treatment Approaches
Thomas Jefferson University
2016-2025
Thomas Jefferson University Hospital
2016-2025
Neurological Surgery
2016-2025
University Hospital of Lausanne
2025
Jefferson Hospital for Neuroscience
2015-2024
Jefferson University Hospitals
2018-2024
The Ohio State University Wexner Medical Center
2024
Temple University
2024
Jefferson Hospital
2023
Neuroscience Institute
2022
<h3>BACKGROUND AND PURPOSE:</h3> Flow diverters are increasingly used in the endovascular treatment of intracranial aneurysms. Our aim was to determine neurologic complication rates following Pipeline Embolization Device placement for aneurysm a real-world setting. <h3>MATERIALS METHODS:</h3> We retrospectively evaluated all patients with aneurysms treated between July 2008 and February 2013 17 centers worldwide. defined 4 subgroups: internal carotid artery ≥10 mm, ICA <10 other anterior...
Self-expanding stents are increasingly used for treatment of complex intracranial aneurysms. We assess the safety and efficacy stenting determine predictors outcomes.A total 508 patients with 552 aneurysms were treated Neuroform Enterprise between 2006 2011 at our institution. A multivariate analysis was conducted to identify complications, recanalization, outcome.Of patients, 461 (91%) electively 47 (9%) in setting subarachnoid hemorrhage. Complications occurred 6.8% patients. In analysis,...
We endeavored to develop an unruptured intracranial aneurysm (UIA) treatment score (UIATS) model that includes and quantifies key factors involved in clinical decision-making the management of UIAs assess agreement for this among specialists UIA research.
Recent case-series of small size implied a pathophysiological association between coronavirus disease 2019 (COVID-19) and severe large-vessel acute ischemic stroke. Given that strokes are typically associated with poor prognosis can be very efficiently treated recanalization techniques, confirmation this putative is urgently warranted in large representative patient cohort to alert stroke clinicians, inform pre- in-hospital pathways. We pooled all consecutive patients hospitalized...
The factors that contribute to periprocedural complications following cranioplasty, including patient-specific and surgery-specific factors, need be thoroughly assessed. aim of this study was evaluate risk predispose patients an increased cranioplasty death.The authors conducted a retrospective review all at their institution who underwent craniectomy for stroke, subarachnoid hemorrhage, epidural hematoma, subdural trauma between January 2000 December 2011. predictors were tested: age, sex,...
Background and Purpose— Flow diversion has emerged as an important tool for the management of intracranial aneurysms. The purpose this study was to compare flow traditional embolization strategies in terms safety, efficacy, clinical outcomes patients with unruptured, large saccular aneurysms (≥10 mm). Methods— Forty treated Pipeline Embolization Device (PED) were matched a 1:3 fashion 120 coiling based on patient age aneurysm size. Fusiform anterior communicating artery eliminated from...
Background Preliminary clinical studies on the safety and efficacy of pipeline embolization device (PED) for treatment small/medium aneurysms have demonstrated high occlusion rates with low complications. Objective To evaluate effectiveness PED wide necked small medium intracranial aneurysms. Methods PREMIER is a prospective, multicenter, single arm trial. Patients were treated unruptured aneurysms, measuring ≤12 mm along internal carotid artery or vertebral artery, between July 2014...
OBJECTIVE The authors performed a pooled analysis of 3 studies-IntrePED (International Retrospective Study the Pipeline Embolization Device), PUFS (Pipeline for Uncoilable or Failed Aneurysms Study), and ASPIRe (Aneurysm in an Observational Registry)-in order to assess angiographic outcomes clinical safety embolization device (PED). METHODS IntrePED was retrospective study, while were prospective studies. For each patient included these studies, collected baseline demographic data, aneurysm...
<b><i>Background and Objective:</i></b> Few prospective studies exist evaluating the safety efficacy of Pipeline Embolization Device (PED) in treatment intracranial aneurysms. The Aneurysm Study In an observational Registry (ASPIRe) study prospectively analyzed rates complete aneurysm occlusion neurologic adverse events following PED <b><i>Materials Methods:</i></b> We performed a multicenter patients with unruptured aneurysms treated PED....
Mechanical thrombectomy (MT) has revolutionized the treatment of acute ischemic stroke (AIS) due to large vessel occlusion (LVO), but its efficacy and safety in medium (MeVO) remain less explored. This multicenter, retrospective study aims investigate incidence clinical outcomes perforations (confirmed by extravasation during an angiographic series) MT for AIS caused MeVO.
Background The efficacy of endovascular treatment (EVT) in acute ischaemic stroke due to distal medium vessel occlusion (DMVO) remains uncertain. Our study aimed evaluate the safety and EVT compared with best medical management (BMM) DMVO. Methods In this prospectively collected, retrospectively reviewed, multicentre cohort study, we analysed data from Multicentre Analysis primary Distal occlusions: effect Mechanical Thrombectomy registry. Patients DMVO M2, M3 M4 segments who underwent or...
Although previous trials have established the efficacy and safety of endovascular thrombectomy (EVT) in large ischemic core strokes, most them excluded patients with extracranial internal carotid artery (e-ICA) occlusion. We aimed to compare outcomes e-ICA occlusion infarcts treated EVT vs medical management (MM). This was a secondary analysis SELECT2 trial, randomized controlled trial conducted at 31 international sites. Adult proximal intracranial anterior circulation defined as Alberta...
M1 and M2 cells are two major subsets of human macrophages that exert opposite effects on the inflammatory response. This study aims to investigate role macrophage M1/M2 imbalance mast in progression cerebral aneurysms rupture.Ten patients with (five ruptured five unruptured) underwent microsurgical clipping. During procedure, a segment aneurysm dome was resected immunostained monoclonal antibodies for (anti-HLA DR), (anti-CD 163), (anti-tryptase clone AA). A superficial temporal artery...
Intracranial stenting has improved the ability to treat wide-neck aneurysms via endovascular techniques. However, stent placement necessitates use of antiplatelet agents, and latter may complicate treatment patients with acutely ruptured who demonstrate hydrocephalus require ventriculostomy. Antiplatelet agents in this setting could increase incidence ventriculostomy-related hemorrhagic complications, but there are insufficient data medical literature quantify potential risk. The aim study...
Background and Purpose— The clinical significance of early (ie, within the first 24 hours) uptake ferumoxytol by macrophages in wall human cerebral aneurysms is not clear. purpose this study was to determine whether suggests unstable aneurysm. Methods— Thirty unruptured 22 patients were imaged with magnetic resonance imaging hours after infusion ferumoxytol. Eighteen also 72 Aneurysm dome tissue collected from 4 signal changes, 5 late other ruptured aneurysms. immunostained for expression...
Little is known about vascular smooth muscle cell (SMC) phenotypic modulation in the cerebral circulation or pathogenesis of intracranial aneurysms. Tumor necrosis factor-alpha (TNF-α) has been associated with aneurysms, but potential mechanisms are unclear. Cultured rat SMCs overexpressing myocardin induced expression key SMC contractile genes (SM-α-actin, SM-22α, myosin heavy chain), while dominant-negative cells suppressed expression. treatment inhibited this phenotype and...
BACKGROUND: The Pipeline Embolization Device (PED) has emerged as a promising treatment for intracranial aneurysms. OBJECTIVE: To assess the safety and efficacy of PED, to analyze effect operator experience on complication rate, identify predictors complications obliteration. METHODS: A total 109 patients with 120 aneurysms were treated PED at our institution. patient population was divided into 3 consecutive equal groups whether overall major rates decreased over time: group 1, 1 through...