Mario Martínez‐Galdámez
A5081437667- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Vascular Malformations Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Moyamoya disease diagnosis and treatment
- Long-Term Effects of COVID-19
- Peripheral Artery Disease Management
- Neurosurgical Procedures and Complications
- Retinal and Optic Conditions
- Intracerebral and Subarachnoid Hemorrhage Research
- Vascular Procedures and Complications
- COVID-19 and healthcare impacts
- COVID-19 Clinical Research Studies
- Spine and Intervertebral Disc Pathology
- Head and Neck Surgical Oncology
- Spinal Hematomas and Complications
- Meningioma and schwannoma management
- Central Venous Catheters and Hemodialysis
- Pituitary Gland Disorders and Treatments
- Telemedicine and Telehealth Implementation
- Cerebral Venous Sinus Thrombosis
- Surgical Simulation and Training
Hospital Clínico Universitario de Valladolid
2014-2025
Universidad de Valladolid
2013-2025
Hospital La Luz
2022-2025
Heidelberg University
2024
Medical University of South Carolina
2024
McLaren Regional Medical Center
2024
University Hospital Heidelberg
2024
Mercy Health
2024
Stryker (United States)
2024
Health and Education Research Management and Epidemiologic Services (United States)
2023
The COVID-19 pandemic led to profound changes in the organization of health care systems worldwide.We sought measure global impact on volumes for mechanical thrombectomy, stroke, and intracranial hemorrhage hospitalizations over a three-month period at height (1 March-31 May 2020) compared with two control periods (immediately preceding one year prior).Retrospective, observational, international study, across 6 continents, 40 countries, 187 comprehensive stroke centers. diagnoses were...
Clinical evidence of the potential treatment benefit mechanical thrombectomy for posterior circulation distal, medium vessel occlusion (DMVO) is sparse.To investigate frequency as well clinical and safety outcomes isolated DMVO stroke to compare them with standard medical or without intravenous thrombolysis (IVT) in daily practice.This multicenter case-control study analyzed patients who were treated primary distal cerebral artery (PCA) P2 P3 segment. These received (with IVT) at 1 23...
BackgroundEndovascular treatment (EVT) of stroke with large-vessel occlusion is known to be safe and effective. The effect EVT for medium or distal vessels unclear.MethodsWe randomly assigned participants an isolated (occlusion the nondominant codominant M2 segment middle cerebral artery [MCA]; M3 M4 MCA; A1, A2, A3 anterior artery; P1, P2, P3 posterior artery) receive plus best medical alone within 24 hours after participant was last seen well. primary outcome level disability at 90 days,...
Background Studies have described a first pass effect (FPE) where patients with successful recanalization after one experience better outcomes. Few studies evaluated this in large core infarctions. Objective To determine whether infarcts undergoing mechanical thrombectomy which reperfusion is achieved improved outcomes compared those who undergo more than pass. Methods The ASSIST Registry, prospective, global, multicenter registry of anterior circulation vessel occlusion (LVO) was used....
Although previous trials have established the efficacy and safety of endovascular thrombectomy (EVT) in large ischemic core strokes, most them excluded patients with extracranial internal carotid artery (e-ICA) occlusion. We aimed to compare outcomes e-ICA occlusion infarcts treated EVT vs medical management (MM). This was a secondary analysis SELECT2 trial, randomized controlled trial conducted at 31 international sites. Adult proximal intracranial anterior circulation defined as Alberta...
The Pipeline Embolization Device (PED) is a routine first-line treatment option for intracranial aneurysms (IAs). Flex with Shield Technology (Pipeline Shield) an updated version of the PED which has been modified to include surface phosphorylcholine biocompatible polymer. Its early technical success and safety have reported previously. Here, we assessed long-term efficacy IAs.The (PFLEX) study was prospective, single-arm, multicenter unruptured IAs using Shield. primary endpoint major...
Background Evidence supporting a potential benefit of thrombectomy for distal medium vessel occlusions (DMVOs) the anterior cerebral artery (ACA) is, to knowledge authors, unknown. Purpose To compare clinical and safety outcomes between mechanical (MT) best medical treatment (BMT) with or without intravenous thrombolysis primary isolated ACA DMVOs. Materials Methods Treatment Primary Medium Vessel Occlusion Stroke, TOPMOST, is an international, retrospective, multicenter, observational...
Background Robotic-assisted neurointervention was recently introduced, with implications that it could be used to treat neurovascular diseases. Objective To evaluate the effectiveness and safety of robotic-assisted platform CorPath GRX for treating cerebral aneurysms. Methods This prospective, international, multicenter study enrolled patients brain aneurysms required endovascular coiling and/or stent-assisted coiling. The primary endpoint defined as successful completion procedure without...
Background Patients treated with mechanical thrombectomy (MT) for acute ischemic strokes from large vessel occlusion (LVO) have better outcomes effective reperfusion. However, it is unknown which technique leads to technical and clinical success. We aimed determine yields the most first pass reperfusion during MT. Methods In a prospective, multicenter global registry we enrolled patients operator preferred MT at 71 hospitals January 2019 2022. Three techniques were assessed: SR Classic stent...
Background and purpose The Pipeline Embolization Device (PED) has become a routine first-line option for treatment of intracranial aneurysms (IAs). We assessed the early safety technical success new version PED, Flex with Shield Technology (Pipeline Shield), which same design configuration but been modified to include surface synthetic biocompatible polymer. Materials methods (PFLEX) study is prospective, single-arm, multicenter unruptured IAs using Shield. primary endpoints included...
Purpose The aim of our study was to assess the technical success and safety this new low-profile flow diverter Silk Vista Baby (SVB) by evaluating intraprocedural periprocedural complication rate. Material/methods Clinical, procedural, angiographic data were analyzed. Results: 41 consecutive patients (28 women; age average 50.5 years) with 43 aneurysms treated SVB. Aneurysm sizes classified their maximum diameter, an size 9.5 mm (range 2–30 mm). Thirty-four cases unruptured. five previously...
Background and Purpose- We aimed to evaluate the impact of brain atrophy on long-term clinical outcome in patients with acute ischemic stroke treated endovascular therapy, more specifically, test whether there are interactions between degree infarct volume, age, determining risk futile reperfusion. Methods- studied consecutive proximal anterior circulation intracranial arterial occlusions therapy achieving successful recanalization. Brain was evaluated baseline computed tomography global...
The first and second generations of the Pipeline Embolization Device (PED) have been widely adopted for treatment intracranial aneurysms (IAs) due to their high associated occlusion rates low morbidity mortality. objective this study was evaluate safety effectiveness third- generation Shield device (PED-Shield) IAs.The SHIELD a prospective, single-arm, multicenter, post-market, observational evaluating PED-Shield IAs. primary efficacy endpoint complete aneurysm without significant parent...
The mechanisms and outcomes in coronavirus disease (COVID-19)-associated stroke are unique from those of non-COVID-19 stroke.To describe the efficacy acute revascularization large vessel occlusion (LVO) setting COVID-19 an international cohort.We conducted multicenter retrospective study consecutively admitted patients with concomitant LVO across 50 comprehensive centers. Our control group constituted historical controls presenting receiving a mechanical thrombectomy between January 2018...
Background Intrasaccular devices have become increasingly popular in the treatment of cerebral aneurysms, particularly at bifurcation. Here we evaluate Contour Neurovascular System, an intrasaccular device for endovascular a multicenter cohort study, largest to best our knowledge. Methods Consecutive patients with intracranial aneurysms treated System between February 2017 and October 2022 10 European neurovascular centers were prospectively collected retrospectively reviewed. Patient...
Background Few clinical studies perform detailed analyses of subtypes intracranial hemorrhage (ICH) after mechanical thrombectomy (MT) used to treat acute ischemic stroke. Symptomatic (sICH) is a formidable complication MT and widely in trials as safety outcome. However, variable definitions sICH are across studies. Objective To radiographically subcategorize post-MT ICH development within this large cohort examine overlap with sICH. Second, the agreement definition local site-reported...
BACKGROUND The use of the Surpass Evolve flow diverter for intracranial aneurysms (IAs) has shown promising results, but there are no studies that evaluated its effectiveness remnant previously treated IAs. This study aimed to evaluate safety and METHODS subanalysis is derived from SEASE (Safety Effectiveness Assessment Evolve) registry, a retrospective, multicentric, international cohort conducted across 15 academic institutions in North America Europe between July 2020 October 2022. Adult...
Background and purpose The aim of our study was to evaluate the safety efficacy pipeline endovascular device for treatment anterior circulation aneurysms at level circle Willis beyond. Methods A consecutive series 25 patients (24 unruptured one ruptured) with treated a were included in analysis. Results We found two minor clinical events (resolved within 7 days procedure), major event (symptoms present after days), no mortality. There aneurysm ruptures or parenchymal hemorrhages during...
While there are reports of acute ischemic stroke (AIS) in coronavirus disease 2019 (COVID-19) patients, the overall incidence AIS and clinical characteristics large vessel occlusion (LVO) remain unclear.To attempt to establish COVID-19 patients an international cohort.A cross-sectional retrospective, multicenter study consecutive admitted with was undertaken from March 1 May 1, 2020 at 12 centers 4 countries. Out those centers, 9 all types strokes data were used calculate rate AIS. Three...
Background: The optimal endovascular strategy for reperfusing distal medium-vessel occlusions (DMVO) remains unknown. This study evaluates angiographic and clinical outcomes of thrombectomy strategies in DMVO stroke the posterior circulation. Methods: TOPMOST (Treatment Primary Medium Vessel Occlusion Stroke) is an international, retrospective, multicenter, observational registry patients treated between January 2014 June 2020. analyzed endovascularly isolated primary cerebral artery P2 P3...
Background Flow diversion is an innovative and increasingly used technique for the treatment of intracranial aneurysms. New flow diverters (FDs) are being introduced to improve safety efficacy this treatment. The aim study was assess safety, feasibility, new Pipeline Vantage (PV) FD. Methods Patients with aneurysms treated PV at 10 international neurovascular centers were retrospectively analyzed. Patient aneurysm characteristics, procedural parameters, complications, grade occlusion...
Background Flow diverters are the first-line treatment for specific intracranial aneurysms (iA). Surpass Evolve (SE) is a new-generation 64-wire flow diverter with high braid angle. Current literature on SE limited. We aimed to report first international real-world experience evaluating safety and effectiveness of SE. Methods The Safety Effectiveness Assessment (SEASE) was multicenter retrospective post-marketing cohort study including consecutive patients treated iAs between 2020 2022....
Introduction: Although flow diverters (FD) are a long-established treatment-option for brain aneurysms, the evidence of data associated with therapy success is still based on relatively small heterogeneous studies. Recent from large prospective registry highly standardized, independent adjudication might provide more insights. Methods: The INSPIRE-A prospective, single arm study aneurysms treated commercially available Medtronic devices, including latest FD technology surface modifications....