Cristina Tiu
A5032261495- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Multiple Sclerosis Research Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Long-Term Effects of COVID-19
- Stroke Rehabilitation and Recovery
- Retinal and Optic Conditions
- Intracranial Aneurysms: Treatment and Complications
- Venous Thromboembolism Diagnosis and Management
- Neurological Disorders and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurosurgical Procedures and Complications
- Dementia and Cognitive Impairment Research
- Glaucoma and retinal disorders
- Atrial Fibrillation Management and Outcomes
- Systemic Lupus Erythematosus Research
- COVID-19 and healthcare impacts
- Cardiovascular and Diving-Related Complications
- Botulinum Toxin and Related Neurological Disorders
- Peripheral Neuropathies and Disorders
- Autoimmune Neurological Disorders and Treatments
- Cardiac Imaging and Diagnostics
- Cerebral Venous Sinus Thrombosis
- Infectious Diseases and Tuberculosis
- Myasthenia Gravis and Thymoma
Carol Davila University of Medicine and Pharmacy
2016-2025
Clinical Emergency Hospital Bucharest
2016-2025
City University of Hong Kong
2023
Emergency University
2012-2022
Hospital de Egas Moniz
2022
University of Thessaly
2022
Boston University
2022
Boston Medical Center
2022
Nicolae Testemițanu State University of Medicine and Pharmacy
2022
University of Toronto
2022
Recent case-series of small size implied a pathophysiological association between coronavirus disease 2019 (COVID-19) and severe large-vessel acute ischemic stroke. Given that strokes are typically associated with poor prognosis can be very efficiently treated recanalization techniques, confirmation this putative is urgently warranted in large representative patient cohort to alert stroke clinicians, inform pre- in-hospital pathways. We pooled all consecutive patients hospitalized...
Background Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has been associated with a significant risk of thrombotic events in critically ill patients. Aim To summarize the findings multinational observational cohort patients SARS-CoV-2 and cerebrovascular disease. Methods Retrospective consecutive adults evaluated emergency department and/or admitted coronavirus disease 2019 (COVID-19) across 31 hospitals four countries (1 February 2020–16 June 2020). The primary outcome was...
Recurrent stroke affects 9% to 15% of people within 1 year. This European Stroke Organisation (ESO) guideline provides evidence-based recommendations on pharmacological management blood pressure (BP), diabetes mellitus, lipid levels and antiplatelet therapy for the prevention recurrent other important outcomes in with ischaemic or transient attack (TIA). It does not cover interventions specific causes stroke, including anticoagulation cardioembolic which are addressed guidelines. was...
COVID-19 infection has been known to predispose patients both arterial and venous thromboembolic events such as deep thrombosis, pulmonary embolism, myocardial infarction, stroke. A few reports from the literature suggest that Cerebral Venous Sinus Thrombosis (CVSTs) may be a direct complication of COVID-19.
Background: For Parkinson disease (PD) patients who have been diagnosed with advanced that can no longer be effectively controlled optimized oral or transdermal medications, a range of device-aided therapies (DAT) are available, comprising either deep brain stimulation infusion providing continuous dopaminergic stimulation. Levodopa–entacapone–carbidopa intestinal gel (LECIG) is the latest DAT for PD (APD) was approved in Romania 2021. Study Question: What experience to date real-world...
The mechanisms and outcomes in coronavirus disease (COVID-19)-associated stroke are unique from those of non-COVID-19 stroke.To describe the efficacy acute revascularization large vessel occlusion (LVO) setting COVID-19 an international cohort.We conducted multicenter retrospective study consecutively admitted patients with concomitant LVO across 50 comprehensive centers. Our control group constituted historical controls presenting receiving a mechanical thrombectomy between January 2018...
Background and objectives: The time interval between stroke onset hospital arrival is a major barrier for reperfusion therapies in acute ischemic usually accounts most of the onset-to-treatment delay. present study aimed to analyze pre-hospital delays patients with admitted tertiary center Romania identify factors associated late arrival. Material methods: population consisted 770 hospitalized diagnosis University Emergency Hospital Bucharest during 6-month period, 1 January 30 June 2018....
We assessed best available data on access and delivery of acute stroke unit (SU) care, intravenous thrombolysis (IVT) endovascular treatment (EVT) in the European region 2019 2020.We compared national per number inhabitants 100 annual incident first-ever ischaemic strokes (AIIS) 46 countries. Population estimates incidence were based United Nations Global Burden Disease Report 2019, respectively.The estimated mean SUs was 3.68 (95% CI: 2.90-4.45) one million (MIH) with 7/44 countries having...
Background Widespread use of ocrelizumab, an anti-CD20 monoclonal antibody, for treating patients with multiple sclerosis (MS), has led to increase in reported adverse events following real-world observation. Among these, drug-induced colitis is a rare, but severe side effect, prompting recent FDA statement regarding this safety concern. Objectives: We analyzed cohort ocrelizumab treated our MS center evaluate the incidence colitis. Methods present critical review available literature on...
Introduction: Evidence regarding the benefit of endovascular therapy (EVT) in patients with acute ischemic stroke (AIS) due to isolated cervical internal carotid artery occlusion (c-ICA-O) is lacking. We assessed outcomes and safety EVT c-ICA-O. Methods: Retrospective multicenter cohort study an AIS c-ICA-O, within 24-h since last-seen-well. Comparisons were made between best medical (BMT). The primary outcome was 3-months modified Rankin Scale (mRS) ordinal shift. Secondary included 3-month...
Introduction Despite the availability of prevention and therapies stroke, their implementation in clinical practice, even low-cost ones, remains poor. In 2015, European Stroke Organisation (ESO) initiated ESO Enhancing Accelerating Treatment (EAST) program, which aims to improve stroke care quality, primarily Eastern Europe. Here, we describe its methods milestones. Patients The EAST program is using an strategy based on a ‘detecting-understanding-reducing disparities’ conceptual framework:...
Abstract Retinal imaging has been proposed as a biomarker for neurological diseases such multiple sclerosis (MS). Recently, technique non-invasive assessment of the retinal microvasculature called optical coherence tomography angiography (OCTA) was introduced. We investigated alterations in participants with relapsing–remitting MS (RRMS) without history optic neuritis (ON) and compared them to healthy control group. The study performed prospective, case–control design, including 58 (n = 100...
Optical coherence tomography (OCT) is a retinal imaging system that may improve the diagnosis of multiple sclerosis (MS) persons, but evidence currently equivocal. To assess whether compensating peripapillary nerve fiber layer (pRNFL) thickness for ocular anatomical features as well combination with macular layers can capability OCT in differentiating non-optic neuritis eyes relapsing-remitting MS patients from healthy controls. 74 participants (n = 129 eyes) and 84 age- sex-matched controls...
Abstract Multiple sclerosis (MS), neurologic disease affecting young population, may cause cardiovascular dysfunction, due to autonomous nervous physical invalidity, increased oxidative stress, and systemic inflammatory status. However, function is rarely evaluated in these patients. We assessed left right ventricular (LV RV) by 2D, 3D, tissue Doppler, speckle tracking echocardiography, vascular remodeling, stiffness, endothelial dysfunction parameters patients with MS, compared control...
Romania has one of the highest incidences stroke and mortality rates in Europe. The rate due to treatable causes is also very high associated with lowest public spending on healthcare European Union. Nonetheless, significant achievements acute care have been made last 5 years, most notably increase national thrombolysis from 0.8% 5.4%. Numerous educational workshops constant communication centers led a solid active network. Due joint efforts this network ESO-EAST project, quality...
(1) Background: Early disability accrual in RRMS patients is frequent and associated with worse long-term prognosis. Correctly identifying the that present a high risk of early progression utmost importance, may be aided by use predictive biomarkers. (2) Methods: We performed prospective cohort study included newly diagnosed patients, minimum follow-up period one year. Biomarker samples were collected at baseline, 3-, 6- 12-month follow-ups. Disability was measured using EDSS-plus score. (3)...
Opsoclonus-myoclonus syndrome (OMS) is a very rare condition with different autoimmune, infectious and paraneoplastic aetiologies or in most cases idiopathic. We report the case of 75-year-old woman who was admitted our department early fall for altered mental status, opsoclonus, multifocal myoclonus, truncal titubation generalized tremor, preceded by 5 day prodrome consisting malaise, nausea, fever vomiting. Brain computed tomography MRI scans showed no significant abnormalities...
Stroke is one of the leading causes disability in Europe. Central and Eastern European countries have highest incidence mortality rates through The improvements stroke prevention treatment did not completely reach quality parameters present Western countries. We features current management
Data on how retinal structural and vascular parameters jointly influence the diagnostic performance of detection multiple sclerosis (MS) patients without optic neuritis (MSNON) are lacking. To investigate changes to detect MSNON from controls, we performed a cross-sectional study 76 eyes 51 MS participants 117 71 healthy controls. Retinal macular ganglion cell complex (GCC), nerve fiber layer (RNFL) thicknesses, capillary densities superficial (SCP) deep plexuses (DCP) were obtained Cirrus...