Robert Simister
A5087177484- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Long-Term Effects of COVID-19
- Advanced MRI Techniques and Applications
- Stroke Rehabilitation and Recovery
- Epilepsy research and treatment
- COVID-19 and healthcare impacts
- Venous Thromboembolism Diagnosis and Management
- COVID-19 Clinical Research Studies
- Vestibular and auditory disorders
- Retinal and Optic Conditions
- Cerebral Venous Sinus Thrombosis
- Advanced NMR Techniques and Applications
- Intracranial Aneurysms: Treatment and Complications
- Moyamoya disease diagnosis and treatment
- Neuroscience and Neuropharmacology Research
- Hospital Admissions and Outcomes
- Advanced Neuroimaging Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Dementia and Cognitive Impairment Research
- Electron Spin Resonance Studies
- Atrial Fibrillation Management and Outcomes
- Trauma and Emergency Care Studies
- Neurosurgical Procedures and Complications
University College London Hospitals NHS Foundation Trust
2012-2025
National Hospital for Neurology and Neurosurgery
2013-2025
University College London
2016-2025
Royal London Hospital
2013-2025
University College Hospital
2015-2025
Biomedical Research Institute
2022-2024
Medical University of Graz
2024
MRC Prion Unit
2024
Hospital de Sant Pau
2022-2024
University Hospital of Bern
2023-2024
Abstract Preliminary clinical data indicate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with neurological and neuropsychiatric illness. Responding to this, a weekly virtual disease 19 (COVID-19) neurology multi-disciplinary meeting was established at the National Hospital, Queen Square, in early March 2020 order discuss begin understand presentations patients suspected COVID-19-related disorders. Detailed paraclinical were collected from cases...
Recent case-series of small size implied a pathophysiological association between coronavirus disease 2019 (COVID-19) and severe large-vessel acute ischemic stroke. Given that strokes are typically associated with poor prognosis can be very efficiently treated recanalization techniques, confirmation this putative is urgently warranted in large representative patient cohort to alert stroke clinicians, inform pre- in-hospital pathways. We pooled all consecutive patients hospitalized...
Objective We set out to determine which characteristics and outcomes of stroke are associated with COVID-19. Methods This case-control study included patients admitted 13 hospitals in England Scotland between 9 March 5 July 2020. collected data on 86 strokes (81 ischaemic intracerebral haemorrhages) evidence COVID-19 at the time onset (cases). They were compared 1384 (1193 191 during same period who never had (controls). In addition, whole group admissions, including another 37 appeared have...
Carotid revascularisation, comprising either carotid endarterectomy or stenting, is offered to patients with stenosis prevent stroke based on the results of randomised trials conducted more than 30 years ago. Since then, medical therapy for prevention has improved. We aimed assess whether asymptomatic and symptomatic a low intermediate predicted risk stroke, who received optimised (OMT), would benefit from additional revascularisation. The Second European Surgery Trial (ECST-2) multicentre...
Hemispatial neglect following right-hemisphere stroke is a common and disabling disorder, for which there currently no effective pharmacological treatment. Dopamine agonists have been shown to play role in selective attention working memory, two core cognitive components of neglect. Here, we investigated whether the dopamine agonist rotigotine would beneficial effect on hemispatial patients. A double-blind, randomized, placebo-controlled ABA design was used, each patient assessed 20 testing...
Carotid stenosis is a common cause of ischaemic stroke and transient attack (TIA). Despite rising recognition centralization services there has been decline in interventions for carotid recent years. The aim this study was to determine the current prevalence management UK. This 1-year prospective observational consecutive patients presenting with stroke, TIA or retinal artery occlusion central London hyperacute unit. Patients significant stenosis, defined as atherosclerotic narrowing 50 per...
Abstract Preliminary pathological and biomarker data suggest that SARS-CoV-2 infection can damage the nervous system. To understand what, where how occurs, we collected serum CSF from patients with COVID-19 characterized neurological syndromes involving PNS CNS (n = 34). We measured biomarkers of neuronal neuroinflammation, compared these non-neurological control groups, which included 94) without 24) COVID-19. detected increased concentrations neurofilament light, a dynamic damage, in those...
To assess gamma-aminobutyric acid (GABA) plus homocarnosine (GABA+) and glutamate glutamine (GLX) concentrations in the frontal lobes of patients with idiopathic generalized epilepsy (IGE).Twenty-one 17 healthy volunteers were studied. A single voxel was prescribed each lobe for subject. Point-resolved spectroscopy (PRESS)-localized short echo time MR (MRS) performed to measure GLX metabolites N-acetylaspartate N-acetylaspartylglutamate (NAAt), creatine phosphocreatine (Cr),...
Clinical studies investigating the effects of hypercapnia and hypercapnic acidosis in acute cerebral injury are limited. The performed so far have mainly focused on outcomes relation to changes partial pressure carbon dioxide pH isolation not evaluated conjunction.To review association compensated during first 24 hours intensive care unit admission hospital mortality adult mechanically ventilated patients with injury.Multicenter, binational retrospective (traumatic brain injury, cardiac...
Carotid endarterectomy is currently recommended for patients with recently symptomatic carotid stenosis ≥50%, based on randomised trials conducted 30 years ago. Several factors such as plaque ulceration, age and associated comorbidities might influence the risk-benefit ratio of revascularisation. A model developed in previous that calculates future risk stroke these features can be used to stratify into low, intermediate or high risk. Since original trials, medical treatment has improved...
Cerebral microbleeds are associated with the risks of ischemic stroke and intracranial hemorrhage, causing clinical dilemmas for antithrombotic treatment decisions. We aimed to evaluate hemorrhage in patients atrial fibrillation treated vitamin K antagonists, direct oral anticoagulants, antiplatelets, combination therapy (i.e. concurrent anticoagulant antiplatelet).
Cerebral amyloid angiopathy (CAA)-associated lobar intracerebral hemorrhage (ICH) has a high risk of recurrence, but the underlying mechanisms remain uncertain. We, therefore, aimed to characterize patterns recurrent ICH.
Cerebral amyloid angiopathy (CAA), a common cause of intracerebral hemorrhage (ICH), is diagnosed using the Boston criteria including magnetic resonance imaging (MRI) biomarkers (cerebral microbleeds (CMBs) and cortical superficial siderosis (cSS). The simplified Edinburgh include computed tomography (CT) (subarachnoid extension (SAE) finger-like projections (FLPs)). underlying mechanisms diagnostic accuracy CT compared to MRI CAA are unknown.We included 140 survivors spontaneous lobar...
Cerebral small vessel disease (SVD) is the major cause of intracerebral hemorrhage (ICH). There no comprehensive, easily applicable classification ICH subtypes according to presumed underlying SVD using MRI. We developed an MRI-based for SVD-related ICH.