James E. Siegler
A5043300449- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Peripheral Artery Disease Management
- Intracranial Aneurysms: Treatment and Complications
- Cerebral Venous Sinus Thrombosis
- Long-Term Effects of COVID-19
- Atrial Fibrillation Management and Outcomes
- Neurological Disorders and Treatments
- COVID-19 and healthcare impacts
- Antiplatelet Therapy and Cardiovascular Diseases
- COVID-19 Clinical Research Studies
- Cardiovascular and Diving-Related Complications
- Neurosurgical Procedures and Complications
- Traumatic Brain Injury Research
- Social Media in Health Education
- Genetic Neurodegenerative Diseases
- Cardiac Imaging and Diagnostics
- Parkinson's Disease Mechanisms and Treatments
- Neurological and metabolic disorders
- Retinal and Optic Conditions
- Health Systems, Economic Evaluations, Quality of Life
University of Chicago
2023-2025
Cooper University Hospital
2020-2025
Cooper University Health Care
2020-2025
Hospital of the University of Pennsylvania
2014-2024
Klinikum Ludwigshafen
2024
Boston University
2021-2024
Boston Medical Center
2021-2024
University of Pittsburgh Medical Center
2024
Cooper Medical School of Rowan University
2020-2024
University Medical Center
2022-2024
Although there is evidence to suggest a high rate of cerebrovascular complications in patients with SARS-CoV-2 infection, anecdotal reports indicate falling new ischemic stroke diagnoses. We conducted an exploratory single-center analysis estimate the change number diagnoses our region, and evaluate proximate reasons for this during COVID-19 pandemic at tertiary care center New Jersey.
Advanced imaging for patient selection in mechanical thrombectomy is not widely available.To compare the clinical outcomes of patients selected by noncontrast computed tomography (CT) vs those perfusion (CTP) or magnetic resonance (MRI) extended time window.This multinational cohort study included consecutive with proximal anterior circulation occlusion stroke presenting within 6 to 24 hours last seen well from January 2014 December 2020. This was conducted at 15 sites across 5 countries...
Background Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has been associated with a significant risk of thrombotic events in critically ill patients. Aim To summarize the findings multinational observational cohort patients SARS-CoV-2 and cerebrovascular disease. Methods Retrospective consecutive adults evaluated emergency department and/or admitted coronavirus disease 2019 (COVID-19) across 31 hospitals four countries (1 February 2020–16 June 2020). The primary outcome was...
To measure the global impact of COVID-19 pandemic on volumes IV thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at height (March 1 to June 30, 2020) compared with 2 control 4-month periods.We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, 457 centers. Diagnoses were identified by their ICD-10 codes or classifications in databases.There 91,373 admissions immediately before 80,894 during months, representing an...
The COVID-19 pandemic led to profound changes in the organization of health care systems worldwide.We sought measure global impact on volumes for mechanical thrombectomy, stroke, and intracranial hemorrhage hospitalizations over a three-month period at height (1 March-31 May 2020) compared with two control periods (immediately preceding one year prior).Retrospective, observational, international study, across 6 continents, 40 countries, 187 comprehensive stroke centers. diagnoses were...
A small randomized controlled trial suggested that dabigatran may be as effective warfarin in the treatment of cerebral venous thrombosis (CVT). We aimed to compare direct oral anticoagulants (DOACs) a real-world CVT cohort. This multicenter international retrospective study (United States, Europe, New Zealand) included consecutive patients with treated anticoagulation from January 2015 December 2020. abstracted demographics and risk factors, hypercoagulable labs, baseline imaging data,...
Reperfusion without functional independence (RFI) is an undesired outcome following thrombectomy in acute ischemic stroke. The primary objective was to evaluate, patients presenting with proximal anterior circulation occlusion stroke the extended time window, whether selection computed tomography (CT) perfusion or magnetic resonance imaging associated RFI, mortality, symptomatic intracranial hemorrhage (sICH) compared noncontrast CT selected patients.The CLEAR study (CT for Late Endovascular...
BACKGROUND: The optimal management of patients with isolated posterior cerebral artery occlusion is uncertain. We compared clinical outcomes for endovascular therapy (EVT) versus medical (MM) in occlusion. METHODS: This multinational case-control study conducted at 27 sites Europe and North America included consecutive presenting within 24 hours time last well from January 2015 to August 2022. Patients treated EVT or MM were multivariable logistic regression inverse probability treatment...
Approximately 10% to 20% of large vessel occlusion (LVO) strokes involve tandem lesions (TLs), defined as concomitant intracranial LVO and stenosis or the cervical internal carotid artery. Mechanical thrombectomy (MT) may benefit patients with TLs; however, optimal management procedural strategy lesion remain unclear.
Mechanical thrombectomy (MT) has revolutionized the treatment of acute ischemic stroke (AIS) due to large vessel occlusion (LVO), but its efficacy and safety in medium (MeVO) remain less explored. This multicenter, retrospective study aims investigate incidence clinical outcomes perforations (confirmed by extravasation during an angiographic series) MT for AIS caused MeVO.
Acute ischemic stroke (AIS) caused by distal medium vessel occlusions (DMVOs) represents a significant proportion of overall cases. While intravenous thrombolysis (IVT) has been primary treatment, advancements in endovascular procedures have led to increased use mechanical thrombectomy (MT) DMVO patients. However, symptomatic intracerebral hemorrhage (sICH) remains critical complication AIS, particularly after undergoing intervention. This study aims identify factors associated with sICH patients MT.
Background The efficacy of endovascular treatment (EVT) in acute ischaemic stroke due to distal medium vessel occlusion (DMVO) remains uncertain. Our study aimed evaluate the safety and EVT compared with best medical management (BMM) DMVO. Methods In this prospectively collected, retrospectively reviewed, multicentre cohort study, we analysed data from Multicentre Analysis primary Distal occlusions: effect Mechanical Thrombectomy registry. Patients DMVO M2, M3 M4 segments who underwent or...
Neurological worsening poststroke is a serious clinical condition that occurs in up to one-third of patients. This brief report summarizes several the current issues faced by neurologists recognizing and managing patients who experience neurological status following hospital admission.
Occult paroxysmal atrial fibrillation (AF) is found in a substantial minority of patients with cryptogenic stroke. Identifying reliable predictors AF after stroke would allow clinicians to more effectively use outpatient cardiac monitoring and ultimately reduce secondary burden.We analyzed retrospective cohort consecutive who underwent 28-day mobile telemetry or transient ischemic Univariate multivariable analyses were performed identify clinical, echocardiographic, radiographic features...
Background and Purpose— Although higher blood pressure variability (BPV) is associated with worse functional outcome after stroke, this association not as well established in large vessel occlusion strokes treated endovascular treatment (EVT). Methods— In post hoc analysis of BEST (Blood Pressure Endovascular Therapy for Ischemic Stroke), a prospective, multicenter cohort study anterior circulation acute ischemic stroke patients undergoing EVT, we determined the BPV poor or death (90-day...
COVID-19 infection has been known to predispose patients both arterial and venous thromboembolic events such as deep thrombosis, pulmonary embolism, myocardial infarction, stroke. A few reports from the literature suggest that Cerebral Venous Sinus Thrombosis (CVSTs) may be a direct complication of COVID-19.
Background and Purpose- The sources of emboli in patients with embolic stroke undetermined source (ESUS) are multiple may not respond uniformly to anticoagulation. In this exploratory subgroup analysis carotid atherosclerosis the NAVIGATE (New Approach Rivaroxaban Inhibition Factor Xa a Global Trial Versus ASA Prevent Embolism)-ESUS trial, we assessed whether treatment effect is consistent overall trial population investigated association recurrent ischemic stroke. Methods- Carotid was...
Background and Purpose- To identify the specific post-endovascular stroke therapy (EVT) peak systolic blood pressure (SBP) threshold that best discriminates good from bad functional outcomes (a priori hypothesized to be 160 mm Hg), we conducted a prospective, multicenter, cohort study with prespecified analysis plan. Methods- Consecutive adult patients treated EVT for an anterior ischemic were enrolled November 2017 July 2018 at 12 comprehensive centers accross United States. All SBP values...
The pandemic caused by the novel coronavirus disease 2019 (COVID-19) has led to an unprecedented paradigm shift in medical care. We sought evaluate whether COVID-19 may have contributed delays acute stroke management at comprehensive centers.Pooled clinical data of consecutive adult patients from 14 US centers (January 1, 2019, July 31, 2020) were queried. rate thrombolysis for nontransferred within Target: Stroke goal 60 minutes was compared between admitted March and (pre-COVID-19), 2020,...