Christopher J. Stapleton
A5032902539- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Vascular Malformations Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Moyamoya disease diagnosis and treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Peripheral Artery Disease Management
- Neurosurgical Procedures and Complications
- Meningioma and schwannoma management
- Cerebrospinal fluid and hydrocephalus
- Cerebral Venous Sinus Thrombosis
- Aortic aneurysm repair treatments
- Spinal Fractures and Fixation Techniques
- Vascular Procedures and Complications
- Intraoperative Neuromonitoring and Anesthetic Effects
- MRI in cancer diagnosis
- Aortic Disease and Treatment Approaches
- Surgical Simulation and Training
- Spinal Hematomas and Complications
- Anatomy and Medical Technology
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac, Anesthesia and Surgical Outcomes
Massachusetts General Hospital
2016-2025
Harvard University
2016-2025
Brigham and Women's Hospital
2009-2025
Louisiana State University
2024
California State University Los Angeles
2024
Neurological Surgery
2010-2023
St. James's Hospital
2023
Neuroscience Institute
2022
Mass General Brigham
2022
St Christopher's Hospice
2021
Mechanical thrombectomy (MT) has revolutionized the treatment of acute ischemic stroke (AIS) due to large vessel occlusion (LVO), but its efficacy and safety in medium (MeVO) remain less explored. This multicenter, retrospective study aims investigate incidence clinical outcomes perforations (confirmed by extravasation during an angiographic series) MT for AIS caused MeVO.
Activation of group I metabotropic glutamate (mGlu) receptors drives the endocannabinoid system to cause both short- and long-term changes synaptic strength in striatum, hippocampus, other brain areas. Although there is strong electrophysiological evidence for a role release mGlu receptor-dependent plasticity, identity transmitter mediating this phenomenon remains undefined. In study, we show that activation triggers biosynthesis 2-arachidonoylglycerol (2-AG), but not anandamide, primary...
BACKGROUND: The supplementary grading system for brain arteriovenous malformations (AVMs) was introduced in 2010 as a tool improving preoperative risk prediction and selecting surgical patients. OBJECTIVE: To demonstrate this multicenter validation study that supplemented Spetzler-Martin (SM-Supp) grades have greater predictive accuracy than (SM) alone. METHODS: Data collected from 1009 AVM patients who underwent resection were used to compare the powers of SM SM-Supp grades. Patients...
Glucose-regulated protein 78 (GRP78)/BiP is a multifunctional which plays major role in endoplasmic reticulum (ER) processing, quality control, maintaining ER homeostasis, and controlling cell signaling viability. Previously, using transgene-induced mammary tumor model, we showed that Grp78 heterozygosity impeded cancer growth through suppression of proliferation promotion apoptosis the Grp78(+/-) mice exhibited dramatic reduction (70%) microvessel density (MVD) endogenous tumors, while...
Stroke remains a major health concern globally, with oral anticoagulants widely prescribed for stroke prevention. The efficacy and safety of mechanical thrombectomy (MT) in anticoagulated patients distal medium vessel occlusions (DMVO) are not well understood.
Background The combination of intravenous thrombolysis (IVT) with mechanical thrombectomy (MT) may have clinical benefits for patients medium vessel occlusion. Purpose To examine whether MT combined IVT is associated different outcomes than alone in acute ischemic stroke (AIS) and Materials Methods This retrospective study included consecutive adult AIS occlusion treated or at 37 academic centers North America, Asia, Europe. Data were collected from September 2017 to July 2021. Propensity...
Background Brain arteriovenous malformations (AVMs) are abnormal connections between feeding arteries and draining veins, associated with significant risks of haemorrhage, seizures other neurological deficits. Preoperative embolization is commonly used as an adjunct to microsurgical resection, the aim reducing intraoperative complications improving outcomes. However, efficacy safety this approach remain controversial. Methods This study a subanalysis Multicenter International Study for...
Background: Arteriovenous malformations (AVMs) are complex vascular anomalies with a high risk of hemorrhage and neurological deficits, especially when located in eloquent brain regions. The eloquence an AVM location is critical factor the treatment planning, influencing both complications long-term functional outcomes. This study aims to compare outcomes between non-eloquent AVMs. Methods: multicenter, retrospective utilized data from Multicenter International Study for Treatment Brain AVMs...
Introduction: The impact of multiple feeding arteries on clinical outcomes cerebral arteriovenous malformations (AVMs) is not well understood. This study aims to compare between AVMs with versus single arteries. Patients and Methods: Data from the Multicenter International Study for Treatment Brain (MISTA) consortium were analyzed. Propensity score matching (PSM) was used balance cohorts. Subgroup analysis conducted ruptured unruptured different treatment options, multivariable logistic...
Abstract Cerebral arteriovenous malformations (AVMs) are congenital vascular anomalies that can lead to severe complications, including hemorrhage and neurological deficits. This study compares the outcomes of microsurgical resection stereotactic radiosurgery (SRS) for SM grade I II AVMs. Out a large multicenter registry, we identified 180 matched patients with AVMs treated either or SRS between 2010 2023. The primary were AVM obliteration rates complications; secondary included status...
CD4(+)CD25(+) regulatory T cells (T regs) play a major role in the maintenance of self-tolerance and immune suppression, although mechanisms controlling reg development suppressor function remain incompletely understood. Herein, we provide evidence that Kruppel-like factor 10 (KLF10/TIEG1) constitutes an important regulator cell CD4(+)CD25(-) activation through distinct involving transforming growth (TGF)-beta1 Foxp3. KLF10 overexpressing induced both TGF-beta1 Foxp3 expression, effect...
Intraoperative dorsal column mapping, transcranial motor evoked potentials (TcMEPs), and somatosensory (SSEPs) have been used in adults to assist with the resection of intramedullary spinal cord tumors (IMSCTs) predict postoperative deficits. The authors sought determine whether changes MEP SSEP waveforms would similarly deficits children.The reviewed charts intraoperative records for children who had undergone IMSCTs as well mapping TcMEP monitoring. Motor potential data were supplemented...
Abstract BACKGROUND: To date, the use of flow-diverting Pipeline Embolization Device (PED) for small intracranial aneurysms (≤ 7 mm) has been reported only in single-center series. OBJECTIVE: evaluate safety and efficacy PED a multicenter cohort. METHODS: Five major academic institutions United States provided data on patient demographics, aneurysm features, treatment characteristics consecutive patients with ≤ mm treated between 2009 2015. Radiographic outcome was assessed digital...
Background Intracranial arteriovenous malformation (AVM) is a common cause of primary intracerebral hemorrhage in young adults. Lesions typically are sporadic and contain somatic mutations KRAS or BRAF. The purpose this study was to identify cohort participants with brain AVM determine if any genotype-phenotype associations exist. Methods Human specimens (n = 16) were collected during clinically-indicated procedure subjected multiplex targeted sequencing using molecular inversion probe...
Persons with pre-existing disabilities represent over one-third of acute stroke presentations, but account for a far smaller proportion those receiving endovascular thrombectomy (EVT) and thrombolysis. This is despite existing ethical, economic, legal, social directives to maximize equity this vulnerable population. We sought determine associations between baseline modified Rankin Scale (mRS) outcomes after EVT.Individuals who underwent EVT were identified from prospectively maintained...
To analyse the clinical characteristics of COVID-19 with acute ischaemic stroke (AIS) and identify factors predicting functional outcome.Multicentre retrospective cohort study patients AIS who presented to 30 centres in USA Canada between 14 March August 2020. The primary endpoint was poor outcome, defined as a modified Rankin Scale (mRS) 5 or 6 at discharge. Secondary endpoints include favourable outcome (mRS ≤2) mortality discharge, ordinal mRS (shift analysis), symptomatic intracranial...