Nils Henninger
A5046584837- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Stroke Rehabilitation and Recovery
- Atrial Fibrillation Management and Outcomes
- Cerebral Venous Sinus Thrombosis
- Intracerebral and Subarachnoid Hemorrhage Research
- Intracranial Aneurysms: Treatment and Complications
- Neurological Disease Mechanisms and Treatments
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Traumatic Brain Injury Research
- Peripheral Artery Disease Management
- Neurological Disorders and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Antiplatelet Therapy and Cardiovascular Diseases
- S100 Proteins and Annexins
- MRI in cancer diagnosis
- Amyotrophic Lateral Sclerosis Research
- Neurogenetic and Muscular Disorders Research
- Cerebrospinal fluid and hydrocephalus
- Long-Term Effects of COVID-19
- Thermal Regulation in Medicine
- Vascular Malformations Diagnosis and Treatment
University of Massachusetts Chan Medical School
2016-2025
Beth Israel Deaconess Medical Center
2011-2024
Harvard University
2011-2024
Thomas Jefferson University
2024
UMass Memorial Medical Center
2012-2024
Massachusetts General Hospital
2011-2024
Brown University
2022-2024
Yale University
2024
Medical University of South Carolina
2024
Instituto Nacional de Neurología y Neurocirugía
2024
With the spread of coronavirus disease 2019 (COVID-19) during current worldwide pandemic, there is mounting evidence that patients affected by illness may develop clinically significant coagulopathy with thromboembolic complications including ischemic stroke. However, limited data on clinical characteristics, stroke mechanism, and outcomes who have a COVID-19. We conducted retrospective cohort study consecutive were hospitalized between March 15, 2020, April 19, within major health system in...
Axonal degeneration is a critical, early event in many acute and chronic neurological disorders. It has been consistently observed after traumatic brain injury, but whether axon driver of injury remains unclear. Molecular pathways underlying the pathology have not defined, there no efficacious treatment for injury. Here we show that mice lacking mouse Toll receptor adaptor Sarm1 (sterile α/Armadillo/Toll-Interleukin homology domain protein) gene, key mediator Wallerian degeneration,...
A small randomized controlled trial suggested that dabigatran may be as effective warfarin in the treatment of cerebral venous thrombosis (CVT). We aimed to compare direct oral anticoagulants (DOACs) a real-world CVT cohort. This multicenter international retrospective study (United States, Europe, New Zealand) included consecutive patients with treated anticoagulation from January 2015 December 2020. abstracted demographics and risk factors, hypercoagulable labs, baseline imaging data,...
Mechanical thrombectomy (MT) has revolutionized the treatment of acute ischemic stroke (AIS) due to large vessel occlusion (LVO), but its efficacy and safety in medium (MeVO) remain less explored. This multicenter, retrospective study aims investigate incidence clinical outcomes perforations (confirmed by extravasation during an angiographic series) MT for AIS caused MeVO.
Acute ischemic stroke (AIS) caused by distal medium vessel occlusions (DMVOs) represents a significant proportion of overall cases. While intravenous thrombolysis (IVT) has been primary treatment, advancements in endovascular procedures have led to increased use mechanical thrombectomy (MT) DMVO patients. However, symptomatic intracerebral hemorrhage (sICH) remains critical complication AIS, particularly after undergoing intervention. This study aims identify factors associated with sICH patients MT.
Background The efficacy of endovascular treatment (EVT) in acute ischaemic stroke due to distal medium vessel occlusion (DMVO) remains uncertain. Our study aimed evaluate the safety and EVT compared with best medical management (BMM) DMVO. Methods In this prospectively collected, retrospectively reviewed, multicentre cohort study, we analysed data from Multicentre Analysis primary Distal occlusions: effect Mechanical Thrombectomy registry. Patients DMVO M2, M3 M4 segments who underwent or...
Small, randomized trials of patients with cervical artery dissection showed conflicting results regarding optimal stroke prevention strategies. We aimed to compare outcomes in treated antiplatelets versus anticoagulation.
A new generation of highly navigable large-bore aspiration catheters and retriever devices for intracranial mechanical thrombectomy has markedly improved recanalization rates, time clinical outcomes. We report collected data utilizing a technique based on combined large lumen catheter partially resheathed stent (ARTS: Aspiration (catheter)-(stent) Retriever Technique Stroke). This is applied, especially in presence bulky/rubbery emboli, when resistance felt while retracting the retriever; at...
While the thrombotic complications of COVID-19 have been well described, there are limited data on clinically significant bleeding including hemorrhagic stroke. The clinical characteristics, underlying stroke mechanism, and outcomes in this particular subset patients especially salient as therapeutic anticoagulation becomes increasingly common treatment prevention COVID-19. We conducted a retrospective cohort study with (both non-traumatic intracerebral hemorrhage spontaneous non-aneurysmal...
A GGGGCC24+ hexanucleotide repeat expansion (HRE) in the C9ORF72 gene is most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), fatal neurodegenerative diseases with no cure or approved treatments that substantially slow disease progression extend survival. Mechanistic underpinnings neuronal death include haploinsufficiency, sequestration RNA-binding proteins nucleus, production dipeptide proteins. Here, we used an adeno-associated viral vector...
Stroke remains a major health concern globally, with oral anticoagulants widely prescribed for stroke prevention. The efficacy and safety of mechanical thrombectomy (MT) in anticoagulated patients distal medium vessel occlusions (DMVO) are not well understood.
Acute ischemic stroke (AIS) from primary medium vessel occlusions (MeVO) is a prevalent condition associated with substantial morbidity and mortality. Despite the common use of mechanical thrombectomy (MT) in AIS, predictors poor outcomes MeVO remain poorly characterized.
Background The combination of intravenous thrombolysis (IVT) with mechanical thrombectomy (MT) may have clinical benefits for patients medium vessel occlusion. Purpose To examine whether MT combined IVT is associated different outcomes than alone in acute ischemic stroke (AIS) and Materials Methods This retrospective study included consecutive adult AIS occlusion treated or at 37 academic centers North America, Asia, Europe. Data were collected from September 2017 to July 2021. Propensity...
Normobaric hyperoxia (NBO) has been shown to extend the reperfusion window after focal cerebral ischemia. Employing diffusion (DWI)- and perfusion (PWI)-weighted magnetic resonance imaging (MRI), effect of NBO (100% started at 30 mins middle artery occlusion (MCAO)) on spatiotemporal evolution ischemia during permanent (pMCAO) transient suture (tMCAO) was investigated (experiment 3). In two additional experiments, time 1) cell death pathways 2) were in pMCAO model. experiment 1, treatment...
<b><i>Background:</i></b> To date limited information regarding outcome-modifying factors in patients with acute intracranial large artery occlusion (ILAO) the anterior circulation is available. Leukoaraiosis (LA) a common finding among ischemic stroke and has been associated poor post-stroke outcomes but its association ILAO remains poorly characterized. This study sought to clarify contribution of baseline LA other risk 90-day outcome (modified Rankin Scale, mRS)...
Statins have been associated with increased risk of intracerebral hemorrhage (ICH), particularly in elderly patients previous ICH. Recurrent ICH the is often related to cerebral amyloid angiopathy. Therefore, we investigated whether statin use prevalence and severity microbleeds (MB), cortico-subcortical (csMB), which are frequently observed angiopathy.We studied 163 consecutive spontaneous who underwent magnetic resonance imaging within 30 days presentation. We retrieved clinical...
Background and Purpose— Patients with a cardioembolic stroke (CES) have worse outcomes than patients other causes of stroke. Among CES, atrial fibrillation (AF) is common comorbidity. Mounting data indicate that AF may be related to pathogenesis beyond acute cerebral thromboembolism. We sought determine whether represents an independent risk factor for severity outcome among CES. Methods— retrospectively analyzed hemispheric CES included in academic medical center’s registry. was determined...
The National Institutes of Health Stroke Scale (NIHSS) provides a reliable, quantitative measure ischemic stroke severity and is predicted by the infarct size. We sought to determine whether leukoaraiosis affects association between size NIHSS.NIHSS diffusion-weighted imaging-defined volumes from 312 prospectively enrolled patients with supratentorial, strokes were analyzed. Leukoaraiosis was graded according Fazekas scale conceptually defined as absent (0; n=44), mild (1-2; n=106), moderate...