A5033653706- Acute Ischemic Stroke Management
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracranial Aneurysms: Treatment and Complications
- Surgical Simulation and Training
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Appendicitis Diagnosis and Management
- Anatomy and Medical Technology
- Diverticular Disease and Complications
- Peripheral Artery Disease Management
- Intraperitoneal and Appendiceal Malignancies
- Telemedicine and Telehealth Implementation
- Cardiac pacing and defibrillation studies
- Sleep and Wakefulness Research
- Urban Green Space and Health
- S100 Proteins and Annexins
- Lanthanide and Transition Metal Complexes
- Simulation-Based Education in Healthcare
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Autoimmune and Inflammatory Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Intraoperative Neuromonitoring and Anesthetic Effects
Universität Hamburg
2018-2024
University Medical Center Hamburg-Eppendorf
2018-2024
Escola Superior de Saúde Egas Moniz
2021
Philipps University of Marburg
2020
Klinik und Poliklinik für Nuklearmedizin
2018
University Hospital Brno
2012
Background/purpose Gender bias in academic medicine has been widely described. In Europe, training and career pathways neurointervention (NI) are heterogeneous. We hypothesize that the access route to neuroradiology specialty NI subspecialty may correlate with proportion of women field their progression. Methods An online survey consisting 18 questions was distributed through European professional societies several social platforms. A total 422 responses from 54 different countries were...
Abstract Glioblastoma multiforme (GBM) is the most aggressive type of brain cancer with a median survival only 15 months. To complement standard treatments including surgery, radiation and chemotherapy, it essential to understand contribution GBM tumor microenvironment. Brain macrophages microglia particularly contribute angiogenesis, major hallmark GBM. ADAM8 , metalloprotease-disintegrin strongly expressed in cells associated immune GBMs, related angiogenesis correlates poor clinical...
Purpose The necrosis-fibrosis hypothesis describes a continuum between single attacks of acute pancreatitis (SAP), recurrent (RAP) and chronic (CP) with endocrine exocrine pancreatic insufficiency. For prevention purposes we evaluated clinico-radiological parameters volumetry to compare SAP RAP provide prognostic relevance on short-term mortality, need for intervention the hospitalization duration. Materials methods We retrospectively investigated 225 consecutive patients (150 males, range...
Early neurological status has been described as predictor of functional outcome in patients with anterior circulation stroke after mechanical thrombectomy. It remains unclear to what proportion the improvement at day 90 is already apparent 24 hours and hospital discharge how later factors impact outcome.All enrolled German Stroke Registry (June 2015-December 2019) availability baseline data were included. A mediation analysis was conducted investigate effect successful recanalization...
Background: Leukodystrophies are a group of rare genetic diseases that primarily affect the white matter central nervous system. The broad spectrum metabolic and pathological causes leads to manifestations at any age, most often in childhood adolescence, variety symptoms. usually progressive, resulting severe disabilities premature death. Progressive visual impairment is common symptom. Currently, no overview manifold neuro-ophthalmologic impact leukodystrophies exists. Methods: Data from...
Three Tesla (T) magnetic resonance imaging (MRI) provides critical information for many conditions. Owing to potential interactions of the field, it is largely withheld from patients with cardiac implantable electronic devices (CIEDs). Therefore, we assessed safety 3T MRI in '3T MRI-conditional' and 'non-3T CIEDs.We performed a retrospective single-centre analysis clinically indicated examinations conventional pacemakers, resynchronization devices, implanted defibrillators April 2020 May...
Abstract Mechanical thrombectomy (MT) for acute ischemic stroke with medium vessel occlusions is still a matter of debate. We sought to identify factors associated clinical outcome after MT M2-occlusions based on data from the German Stroke Registry-Endovascular Treatment (GSR-ET). All patients prospectively enrolled in GSR-ET 05/2015 12/2021 were analyzed (NCT03356392). Inclusion criteria primary and availability relevant data. Factors excellent/good (modified Rankin scale mRS 0–1/0–2),...
Abstract This work introduces version 2.0 of the Hamburg ANatomical NEurointerventional Simulator (HANNES): a novel modular neurointerventional simulator designed to provide realistic platform for simulating various neurovascular pathologies and their endovascular therapies. Collaboratively developed by physicians engineers, is with product architecture combining standardized variant modules represent different training scenarios. The additively manufactured patient-based patient-specific...
In an ischaemic stroke, a blood clot (thrombus) occludes one of the arteries supplying brain with oxygen. such cases, prompt and safe removal thrombus by interventional physicians is high importance. The procedure mechanical thrombectomy mainly trained on animal models or simple flow animal- human-based thrombi. aim this study to develop completely free model for use in existing physical neurointerventional simulation model. Based requirements established treating supplemented broad...
Purpose The increased demand for training of mechanical thrombectomy in ischemic stroke and development new recanalization devices urges the creation simulation models both device assessment. Clots properties have shown to play a role procedural planning effectiveness. In this study, we analyzed characteristics applicability completely synthetic, animal-free clots setting an in-vitro model Methods Synthetic based on agarose (n = 12) silicone 11) were evaluated neurointervention with clot...
Given the inherent complexity of neurointerventional procedures and associated risks ionizing radiation exposure, it is crucial to prioritize ongoing training improve safety protocols. The aim this study assess a evaluation
Objective To meet increasing demands to train neuroendovascular techniques, we developed a dedicated simulator applying individualized three-dimensional intracranial aneurysm models (‘HANNES’; Hamburg Anatomic Neurointerventional Endovascular Simulator). We hypothesized that HANNES provides realistic and reproducible training environment practice coil embolization exemplify disparities between neurointerventionalists, thus objectively benchmarking operators at different levels of experience....
Remote access of trainees to training centers via video streaming (tele-observership, e‑fellowship) emerges as an alternative acquire knowledge in endovascular interventions. Situational awareness is a summary term that also used surgical procedures for perceiving and understanding the situation projecting what will happen next. A high situational would serve prerequisite meaningful learning success during tele-observerships. We hypothesized live perception angiographical using technology...
Abstract Glioblastoma (GBM) is an exceptionally aggressive brain tumor with a dismal prognosis, demanding fast and precise classification as base for patient-specific treatment strategies. Here, we report on adolescent patient histologically bona fide GBM that shows molecular methylation profile suggesting low-grade glioma-like subgroup. Despite early relapse, intolerance of temozolomide, change strategy to vinblastine valproic acid (VPA), the now in good clinical condition after more than 5...
Abstract Purpose Flow arrest using a balloon guide catheter (BGC) in mechanical thrombectomy (MT) due to large vessel occlusion has been associated with better outcomes. Known limitations of currently commercially available BGCs are incompatibility bore aspiration catheters (AC) and lack distal flexibility. Walrus presents variable stiffness compatibility AC. The goal this study is describe the first experience realistic stroke simulation model. Methods A full-length modular vascular model...
Introduction: Managing blood pressure in patients with large vessel occlusion affects infarct size and clinical outcomes. We examined how restoring flow impacts systemic during mechanical thrombectomy. Patients Methods: the anterior circulation undergoing thrombectomy between June 2016 January 2018 were screened. included those treated under local anesthesia or conscious sedation analyzed standardized protocols to assess systolic diastolic levels throughout procedure. The primary outcome was...
Arterial spin labeling blood perfusion signal relies on the difference between a label and control image. Background suppression pulses are commonly used to improve contrast, yet these based estimates of tissue relaxation times. The aim this study is contrast by individualizing timing background means T1 mapping.The optimized obtained rapid mapping employing variable flip angle technique. Ten healthy volunteers were included in study. To compare results, visual grading Wilcoxon signed-rank...
Introduction An increased consumption of fresh fruit and vegetables is associated with health benefits [1 World Health Organization. Increasing vegetable to reduce the risk noncommunicable diseases. Available from: https://www.who.int/elena/titles/fruit_vegetables_ncds/en/ [Google Scholar],2 Hartley L, Igbinedion E, Holmes J, Flowers N, Thorogood M, Clarke A, Stranges S, Hooper Rees K. Increased for primary prevention cardiovascular Cochrane Database Syst Rev. 2013;2013(6):CD009874,1--55....