Mahmoud Elhorany
A5059385439- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Intracranial Aneurysms: Treatment and Complications
- Antiplatelet Therapy and Cardiovascular Diseases
- Peripheral Artery Disease Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Vascular Malformations Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Intracerebral and Subarachnoid Hemorrhage Research
- Cerebral Venous Sinus Thrombosis
- Retinal and Optic Conditions
- Spine and Intervertebral Disc Pathology
- Neurosurgical Procedures and Complications
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Atrial Fibrillation Management and Outcomes
- Central Venous Catheters and Hemodialysis
- Pelvic and Acetabular Injuries
- Vascular anomalies and interventions
- MicroRNA in disease regulation
- Spinal Fractures and Fixation Techniques
- Vascular Procedures and Complications
- S100 Proteins and Annexins
Assistance Publique – Hôpitaux de Paris
2020-2024
Tanta University
2020-2024
Pitié-Salpêtrière Hospital
2020-2024
Sorbonne Université
2020-2024
Université Paris Cité
2024
Biomarqueurs d’urgence et de réanimation
2020-2022
Hôpital Lariboisière
2021
Tanta University Hospital
2021
Université Sorbonne Nouvelle
2020
Université Paris 8
2020
Mechanical thrombectomy (MT) has revolutionized the treatment of acute ischemic stroke (AIS) due to large vessel occlusion (LVO), but its efficacy and safety in medium (MeVO) remain less explored. This multicenter, retrospective study aims investigate incidence clinical outcomes perforations (confirmed by extravasation during an angiographic series) MT for AIS caused MeVO.
Whether endovascular therapy (EVT) added on best medical management (BMM), as compared to BMM alone, is beneficial in acute ischemic stroke with isolated posterior cerebral artery occlusion unknown.We conducted a multicenter international observational study of consecutive patients admitted within 6 hours from symptoms onset 26 centers the first (P1) or second (P2) segment and treated either BMM+EVT alone. Propensity score inverse probability treatment weighting was used account for baseline...
Stroke remains a major health concern globally, with oral anticoagulants widely prescribed for stroke prevention. The efficacy and safety of mechanical thrombectomy (MT) in anticoagulated patients distal medium vessel occlusions (DMVO) are not well understood.
The mechanisms and outcomes in coronavirus disease (COVID-19)-associated stroke are unique from those of non-COVID-19 stroke.To describe the efficacy acute revascularization large vessel occlusion (LVO) setting COVID-19 an international cohort.We conducted multicenter retrospective study consecutively admitted patients with concomitant LVO across 50 comprehensive centers. Our control group constituted historical controls presenting receiving a mechanical thrombectomy between January 2018...
Introduction: First pass effect (FPE), achievement of complete recanalization (mTICI 2c/3) with a single pass, is significant predictor favorable outcomes for endovascular treatment (EVT) in large vessel occlusion stroke (LVO). However, data concerning the impact on functional and predictors FPE medium occlusions (MeVO) are scarce. Patients Methods: We conducted an international retrospective study MeVO cases. Multivariable logistic modeling was used to establish independent FPE. Clinical...
Background For acute proximal intracranial artery occlusions, contact aspiration may be more effective than stent‐retriever for first‐line reperfusion therapy. Due to the lack of data regarding medium vessel occlusion thrombectomy, we evaluated outcomes according technique in a large, multicenter registry. Methods Imaging, procedural, and clinical patients with occlusions (M2, A1, or P1) distal (M3, A2, P2, further) treated at 37 sites 10 countries were analyzed endovascular (stent‐retriever...
Acute ischemic stroke and large vessel occlusion can be concurrent with the coronavirus disease 2019 (COVID-19) infection. Outcomes after mechanical thrombectomy (MT) for in patients COVID-19 are substantially unknown. Our aim was to study early outcomes MT COVID-19.Multicenter, European, cohort involving 34 centers France, Italy, Spain, Belgium. Data were collected between March 1, 2020 May 5, 2020. Consecutive laboratory-confirmed cases occlusion, who treated MT, included. Primary...
Background Endovascular treatment (EVT) for basilar artery occlusions (BAO) is associated with a higher rate of futile recanalization compared anterior circulation procedures. We aimed to identify the incidence and predictors poor clinical outcome despite successful reperfusion in current practice. Methods used data from ETIS (Endovascular Treatment Ischemic Stroke) registry, prospective multicenter observational registry stroke treated EVT France. Patients undergoing acute BAO January 2014...
<h3>BACKGROUND AND PURPOSE:</h3> Rescue endovascular and pharmacologic approaches are increasingly being adopted after recanalization failure of acute large-vessel occlusion strokes with mechanical thrombectomy, encouraging results. The safety efficacy glycoprotein IIb/IIIa inhibitors in ischemic stroke have been investigated, though cangrelor, a recent intravenous P2Y12-receptor inhibitor rapid onset/offset action short half-life, may be valuable option. We compared the cangrelor those for...
Previous studies suggest that mechanisms and outcomes in patients with COVID-19-associated stroke differ from those non-COVID-19-associated strokes, but there is limited comparative evidence focusing on these populations. The aim of this study, therefore, was to determine if a significant association exists between COVID-19 status revascularization functional following thrombectomy for large vessel occlusion (LVO), after adjustment potential confounding factors.A cross-sectional,...
The number of mechanical thrombectomy (MT) passes is strongly associated with angiographic reperfusion as well clinical outcomes in patients anterior circulation ischemic stroke. However, these associations have not been analyzed basilar artery occlusion (BAO). We investigated the influence MT on degree and outcomes, compared outcome after ≤3 versus >3 passes.We used data from prospective multicentric Endovascular Treatment Ischemic Stroke (ETIS) Registry at 18 sites France. Patients BAO...
Background Acute ischemic stroke is a neurologic emergency associated with severe disability and death. There growing evidence that neutrophil extracellular traps (NETs) contribute to the pathogenesis of acute stroke. By mechanical removal occluding thrombus from patient's vasculature, endovascular thrombectomy enables collection material for immunohistologic analysis. The aim our study was strengthen association NET content in thrombi clinical outcome guide future therapeutics. Methods We...