Serge Timsit
A5051923296- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Venous Thromboembolism Diagnosis and Management
- Intracranial Aneurysms: Treatment and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Stroke Rehabilitation and Recovery
- Traumatic Brain Injury and Neurovascular Disturbances
- Atrial Fibrillation Management and Outcomes
- Cardiovascular and Diving-Related Complications
- Neurogenesis and neuroplasticity mechanisms
- Neurosurgical Procedures and Complications
- Antiplatelet Therapy and Cardiovascular Diseases
- Cerebral Venous Sinus Thrombosis
- Urinary Tract Infections Management
- Protease and Inhibitor Mechanisms
- Cardiac Arrhythmias and Treatments
- Vascular Malformations Diagnosis and Treatment
- Pediatric Urology and Nephrology Studies
- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Neurological Disorders and Treatments
- Nerve injury and regeneration
- Enterobacteriaceae and Cronobacter Research
- Mitochondrial Function and Pathology
- Neurological Disease Mechanisms and Treatments
Centre Hospitalier Régional Universitaire de Brest
2016-2025
Université de Bretagne Occidentale
2015-2025
Inserm
2016-2025
Hôpital Gui de Chauliac
2024
Laboratoire Lorrain de Recherche en Informatique et ses Applications
2023
Hôpital Maison Blanche
2013-2023
Génétique, Génomique Fonctionnelle et Biotechnologies
2017-2023
Health and Education Research Management and Epidemiologic Services (United States)
2023
Centre de Recherche en Neurosciences de Lyon
2021
Thales (Portugal)
2020-2021
Trials of patent foramen ovale (PFO) closure to prevent recurrent stroke have been inconclusive. We investigated whether patients with cryptogenic and echocardiographic features representing risk would benefit from PFO or anticoagulation, as compared antiplatelet therapy.In a multicenter, randomized, open-label trial, we assigned, in 1:1:1 ratio, 16 60 years age who had recent attributed PFO, an associated atrial septal aneurysm large interatrial shunt, transcatheter plus long-term therapy...
<h3>Importance</h3> The best reperfusion strategy in patients with acute minor stroke and large vessel occlusion (LVO) is unknown. Accurately predicting early neurological deterioration of presumed ischemic origin (END<sub>i</sub>) following intravenous thrombolysis (IVT) this population may help to select candidates for immediate transfer additional thrombectomy. <h3>Objective</h3> To develop validate an easily applicable predictive score END<sub>i</sub>following IVT LVO. <h3>Design,...
The use of thrombectomy in patients with acute stroke and a large infarct unrestricted size has not been well studied.
Products of the PLP gene, proteolipid protein and its isoform DM-20, are most abundant proteins in CNS myelin, markers oligodendrocyte, myelin-forming cell CNS. The DM-20 transcript has previously been reported to be expressed newborn oligodendrocyte progenitor cells during embryonic development. We have therefore used a cRNA probe follow, by situ hybridization, lineage DM-20-expressing were first detected at E9.5 ventricular germinal layer laterobasal plate diencephalon. At E14.5, DM-20+...
Hyperacute cerebral infarction trials require early differentiation of subtype. Our aim was to determine clinical factors predictive subtype from data collected in the hours admission. Using 1,273 patients enrolled Stroke Data Bank, stroke risk and demographic, clinical, radiological features were compared between 246 cardioembolic 113 large-vessel atherosclerotic infarcts. Bank definitions ensured more transient ischemic attacks infarcts cardiac disease infarcts, but diagnosis distinguished...
We used both the polymerase chain reaction (PCR) and in situ hybridization to search for presence of proteolipid protein (PLP) gene transcripts developing mouse. Total brain RNA extracted from 13-19-day embryos, analyzed by PCR, demonstrated a single transcript that was unambiguously identified with DM-20 mRNA. samples postnatal day 2 animals also showed signal corresponding PLP transcript, addition message. By 10-day embryos using antisense cRNA probe, we localization message restricted...
Abstract Matrix metalloproteinases (MMPs) belong to a large family of endopeptidases that regulate the pericellular environment through cleavage protein components extracellular matrix, membrane receptors and cytokines. MMP activity is controlled by multifunctional tissue inhibitors (TIMPs). Proteases their are critically involved in developmental pathological processes numerous organs, including brain. Global transient cerebral ischemia induces selective delayed neuronal death...
Abstract Several observations suggest that delayed neuronal death in ischaemia, epilepsy and other brain disorders includes an apoptotic component, involving programmed cell (PCD). PCD is hypothesized to result, part, from aberrant control of the cycle. Because they are instrumental mitosis, cyclins D key markers evaluate whether neurons indeed progress into cycle situations pathology. Therefore, we investigated rat brains, expression occurs following transient global ischaemia...
We investigated in vivo the expression of tissue inhibitor metalloproteinases-1 (TIMP-1) rat CNS after kainate (KA)-induced excitotoxic seizures. In situ hybridization revealed that TIMP-1 mRNA is induced rapidly and massively most regions adult forebrain KA treatment. Neuronal activity seems to be necessary but not sufficient trigger induction, because it observed seizing 10-d-old pups, unlike what 21- 35-d-old animals The rapid induction prevented by protein synthesis cycloheximide,...
Although quite challenging, neuroprotective therapies in ischemic stroke remain an interesting strategy to counter mechanisms of injury and reduce brain tissue damage. Among potential drug, cyclin-dependent kinases (CDK) inhibitors represent therapeutic candidates. Increasing evidence indisputably links cell cycle CDKs CDK5 the pathogenesis stroke. recent studies have demonstrated promising efficacies pharmacological CDK related animal models, none them were however clinically relevant human...
Background and Purpose— Intensive physical therapy (PT) facilitates motor recovery when provided during a subacute stage after stroke. The efficiency of very early intensive PT has been less investigated. We aimed to investigate whether conducted within the first 2 weeks could aid control. Methods— This multicentre randomized controlled trial compared soft (20-min/d apart from respiratory needs) (idem+45 minutes exercises/day) initiated 72 hours hemispheric primary outcome was change in...
Primary familial brain calcification (PFBC) is a rare neurogenetic disorder with diverse neuropsychiatric expression. Mutations in four genes cause autosomal dominant PFBC: SLC20A2, XPR1, PDGFB and PDGFRB. Recently, biallelic mutations the MYORG gene have been reported to PFBC an recessive pattern of inheritance. We screened 29 unrelated probands negatively for identified 11 families or novel predicted damaging variant. studied clinical radiological features 16 patients these compared them...
Background and hypothesis There is no consensus on the optimal endovascular management of extracranial internal carotid artery steno-occlusive lesion in patients with acute ischemic stroke due to tandem occlusion. We hypothesized that intracranial mechanical thrombectomy plus emergent stenting (and at least one antiplatelet therapy) superior alone Study design TITAN an investigator-initiated, multicenter, prospective, randomized, open-label, blinded-endpoint (PROBE) study. Eligibility...
We compared clinical and radiologic features between 246 cardiac embolism (EMB) 66 arterial embolic (tandem pathology [TAP]) patients selected from the 1,273 with cerebral infarction in Stroke Data Bank. Diagnostic definitions accounted for increased frequency of disease among EMB TAP (78.4% versus 29.3%), while transient ischemic attacks (32.3% 13.1%) carotid artery bruit (15.1% 3.3%) were more prevalent than EMB. Multiple logistic regression differentiated further. The probability a...
Objectives To assess the management of febrile urinary-tract infection (FUTIs) due to extended-spectrum β-lactamase–producing Enterobacteriaceae (ESBL-E) in children, Pediatric Infectious Diseases Group French Society set up an active surveillance network pediatric centers across France 2014. Materials and methods We prospectively analysed data from 2014 2016 for all children < 18 years old who received antibiotic treatment FUTI ESBL-E 24 centers. Baseline demographic, clinical features,...
Background: Pulmonary embolism (PE) is associated with increased risk for ischemic stroke, but the underlying mechanism remains unclear. The authors hypothesized that paradoxical through patent foramen ovale (PFO) should be main mechanism. Objective: To determine frequency of recent stroke in patients symptomatic PE according to whether PFO was detected. Design: Prospective cohort study masked assessment outcomes. (ClinicalTrials.gov: NCT01216423) Setting: 4 French hospital centers....
Procedural complications in thrombectomy for large vessel occlusions of the anterior circulation are not well described. We investigated incidence, risk factors, and clinical implications daily practice.We used data from ongoing prospective multicenter observational Endovascular Treatment Ischemic Stroke Registry France. The present study is a retrospective analysis 4029 stroke patients with treated between January 2015 May 2020 18 centers. systematically collected procedural data, incidence...
Background Studies have suggested that collateral status modifies the effect of successful reperfusion on functional outcome after endovascular therapy (EVT). We aimed to assess association between and EVT outcomes investigate whether modified outcomes. Methods used data from ongoing, prospective, multicenter Endovascular Treatment in Ischemic Stroke (ETIS) Registry. Collaterals were graded according American Society Interventional Therapeutic Neuroradiology/Society Radiology (ASITN/SIR)...
Objective Cerebral venous thrombosis (CVT) caused by vaccine‐induced immune thrombotic thrombocytopenia (VITT) is a rare adverse effect of adenovirus‐based severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2) vaccines. In March 2021, after autoimmune pathogenesis VITT was discovered, treatment recommendations were developed. These comprised immunomodulation, non‐heparin anticoagulants, and avoidance platelet transfusion. The aim this study to evaluate adherence these its association...
Mechanical thrombectomy (MT) associated with the best medical treatment (BMT) has recently shown efficacy for management of acute ischemic stroke (AIS) secondary to a large vessel occlusion. However, evidence is lacking regarding benefit MT more distal occlusions.
The population structure of extraintestinal pathogenic Escherichia coli evolves over time, notably due to the emergence antibiotic-resistant clones such as ESBL-producing Enterobacteriaceae (ESBL-E).To analyse by WGS genetic diversity a large number ESBL-E isolated from urinary tract infections in children paediatric centres across France between 2014 and 2017 collected National Observatory febrile infection (FUTI) caused ESBL-E.A total 40 905 Enterobacteriaceae-positive urine cultures were...
Importance Cerebral small vessel diseases (CSVDs) account for one-fifth of stroke cases. Numerous familial cases remain unresolved after routine screening known CSVD genes. Objective To identify novel genes and mechanisms associated with CSVD. Design, Setting, Participants This 2-stage study involved linkage analysis a case-control study; whole exome genome sequencing were used to candidate gene variants in 2 large families (9 patients CSVD). Then, was conducted on 246 unrelated probands,...
Health disparities along the rural-urban spectrum are a growing concern. The objective of this study was to determine whether in France, clinical profile, care and outcome after ischemic stroke differed between patients affiliated statutory health insurance system dedicated agricultural economic sector (i.e., Mutualité Sociale Agricole [MSA]) all other patients. Data on aged≥20 years hospitalized for mainland France 2018 were extracted from French National Insurance System. Age-standardized...