A5025590793- Obstructive Sleep Apnea Research
- Prostate Cancer Treatment and Research
- Acne and Rosacea Treatments and Effects
- Radiopharmaceutical Chemistry and Applications
- Blood Pressure and Hypertension Studies
- IL-33, ST2, and ILC Pathways
- Dermatology and Skin Diseases
- Multiple Sclerosis Research Studies
- Pregnancy and Medication Impact
- Cancer Immunotherapy and Biomarkers
- Allergic Rhinitis and Sensitization
- Vitamin C and Antioxidants Research
- Pharmacological Effects and Toxicity Studies
- Heart Rate Variability and Autonomic Control
- Acute Ischemic Stroke Management
- Urticaria and Related Conditions
- Central Venous Catheters and Hemodialysis
- Data Quality and Management
- SARS-CoV-2 and COVID-19 Research
- Retinoids in leukemia and cellular processes
- Prostate Cancer Diagnosis and Treatment
- Drug-Induced Ocular Toxicity
- Vascular Malformations and Hemangiomas
- Healthcare Systems and Practices
- Hormonal and reproductive studies
Hospital Damas
2025
École des Hautes Études en Santé Publique
2019-2024
Université de Rennes
2018-2024
Centre Hospitalier Universitaire de Rennes
2018-2024
Inserm
2022-2023
Institut de Recherche en Santé, Environnement et Travail
2023
Centre Hospitalier Universitaire de Tours
2022
Pharmac
2022
Agence Nationale de Sécurité du Médicament et des Produits de Santé
2017
<h3>Importance</h3> Ustekinumab, a monoclonal antibody targeting interleukin 12/23p40 (IL-12/23p40), is effective in the treatment of moderate to severe psoriasis, psoriatic arthritis, and Crohn disease. In 2011, meta-analysis randomized clinical trials reported potential risk cardiovascular events (SCEs) within first few months after initiation anti–IL-12/23p40 antibodies. <h3>Objective</h3> To assess whether ustekinumab associated with increased SCEs. <h3>Design, Setting, Participants</h3>...
The safety of oral propranolol for infantile hemangioma has not yet been studied at population level since the pediatric use marketing authorization was obtained in Europe.A survey a nationwide, claim-based observational cohort children <3 years old, with least 1 delivery between July 2014 and June 2016, performed by using database French National Health Insurance system. Standardized morbidity ratios (SMRs) were calculated using, from same database, representative random sample nonexposed...
Background: Previous studies have shown that people with multiple sclerosis (MS) had frequent healthcare visits up to 10 years before being diagnosed but no information from magnetic resonance imaging (MRI) scans of the connection radiologically isolated syndrome (RIS). Objective: To analyze use 3 RIS diagnosis. Methods: We examined usage first scan in cases 2010 2019. subjects were identified French National MS observatory and compared general population (matched 10:1) patients 4:1)....
Sleep apnoea specific heart rate response (ΔHR) has been identified as a promising biomarker for stratifying cardiovascular (CV) risk, and predicting positive airway pressure (PAP) benefit in obstructive sleep (OSA). However, the need prior manual scoring of respiratory events potentially limits accessibility reproducibility ΔHR. We aimed to evaluate association pulse oxygen desaturations automatically derived from oximetry (ΔHRoxi) with CV risk OSA. ΔHRoxi ΔHR were measured OSA patients...
Health disparities along the rural-urban spectrum are a growing concern. The objective of this study was to determine whether in France, clinical profile, care and outcome after ischemic stroke differed between patients affiliated statutory health insurance system dedicated agricultural economic sector (i.e., Mutualité Sociale Agricole [MSA]) all other patients. Data on aged≥20 years hospitalized for mainland France 2018 were extracted from French National Insurance System. Age-standardized...
Abstract Background The impact of Positive Airway Pressure (PAP) therapy on the use oral antihypertensive drugs (OAHDs) in patients with obstructive sleep apnoea (OSA) remains unclear. This study aimed to evaluate association between PAP and delivery OAHDs. Methods Data from Pays de la Loire Sleep Cohort were linked French health insurance database quantify OAHD hypertension at initiation therapy. primary endpoint was change score, reflecting number classes delivered. groups defined as:...
Isotretinoin is the only effective treatment for severe acne. An isotretinoin-related suicide risk still debated and under scrutiny by regulatory agencies. Our objectives were: to assess of attempt before, during after isotretinoin treatment; detect any potential triggering effect initiation on attempt.We implemented a cohort nested case-time-control study subjects treated with oral (course or initiation) aged 10-50 years, using Nationwide French Health Insurance data (2009-2016). The main...
Abiraterone acetate (ABI) and enzalutamide (ENZ) are considered to be clinically relevant comparators among chemotherapy-naive patients with castration-resistant prostate cancer. No clinical trials comparing overall survival ABI versus ENZ in a head-to-head approach have been published so far. A few observational studies low power suggested potential benefit of ENZ. We used the French National Health Data System compare new users cancer 2014-2017, followed through 2018 (the SPEAR cohort,...
Safety profiles of abiraterone and enzalutamide rely mainly on Phase III clinical trials. Our objective was to estimate the incidence rate ratio (IRR) for certain adverse events leading in real life hospitalization (atrial fibrillation, acute heart failure, ischaemic disease, kidney injury [AKI], stroke, torsade de pointe/QT interval prolongation, hepatitis seizure), comparing enzalutamide. We also set out discuss previously identified safety signals.Using French National Health Insurance...
Abstract Background Although the causal role of isotretinoin in suicidal behaviour is controversial, suicide attempts ( SA ) do occur among patients taking isotretinoin. Objectives To describe patient profiles and management who committed or attempted under treatment. assess risk factors for Methods We performed a comprehensive case series suicides s isotretinoin, case–control study, using Nationwide French Health Insurance database. The main analysis compared cases (subjects with during...
Several observational studies have reported a decreased response to immune checkpoint inhibitors (ICI) following antibiotic use. ICI activity has been hypothesized be impaired by antibiotic-induced gut dysbiosis.Patients with advanced melanoma receiving an anti-PD-1 antibody as first-line therapy between 2015 and 2017 in France were selected using the French Health Insurance database. We compared overall survival time-to-treatment discontinuation according exposure 3 months prior initiation...
Abstract In France, most spirometries are performed by pneumologists. Spirometry is difficult to access due the distance medical office and long delays for appointments. This lack of accessibility contributes underdiagnosis chronic obstructive pulmonary disease (COPD) among patients aged between 40 75 years. recent years, general practitioners (GPs) have been performing spirometry in private practice. However, extent this practice unknown. A French retrospective, repetitive transversal study...
Abstract Angiotensin‐converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs) both inhibit the renin‐angiotensin system (RAS) but have different sites of action. Whether clinically meaningful differences exist is still debated. The authors set up a population‐based nationwide retrospective cohort study with at least 5 years follow‐up based on comprehensive French Health Insurance Database linked to hospital discharge database. Patients aged 50 or above, identified as...
Multiple sclerosis (MS) is usually diagnosed between 20-40 years old, when women often plan to have children.Our objectives were estimate pregnancy incidence rates in with multiple (MS), and describe the use of disease-modifying therapies (DMTs) before conception during pregnancy, outcomes.This retrospective cohort study included all 15- 49-year-old MS French national health insurance database over 2010-2015. A was exposed if a DMT reimbursement claim occurred or 14 preceding days. We used...
To describe pregnancies exposed to teriflunomide (TERIF) in women with multiple sclerosis (MS) France over the period 2014-2016.All 15- 49-year-old MS national health insurance database were included. Pregnancies that had started between August 2014 and March 2016 identified from their outcomes. Three groups according treatment exposure compared: TERIF, interferons (IFNs) or glatiramer acetate, no medication.Among 44,008 followed 24.5 months on average, 2,639 identified. There 1,538 (58.3%)...