A5082964689- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Cardiovascular and Diving-Related Complications
- Cardiovascular Syncope and Autonomic Disorders
- Non-Invasive Vital Sign Monitoring
- Heart Rate Variability and Autonomic Control
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular Health and Disease Prevention
- Sleep and Wakefulness Research
- Blood Pressure and Hypertension Studies
- Venous Thromboembolism Diagnosis and Management
- Restless Legs Syndrome Research
- Sleep and related disorders
- Respiratory Support and Mechanisms
- Sleep and Work-Related Fatigue
- High Altitude and Hypoxia
- Inflammatory Myopathies and Dermatomyositis
- Nutritional Studies and Diet
- Cardiovascular Health and Risk Factors
- Chronic Myeloid Leukemia Treatments
- EEG and Brain-Computer Interfaces
- Cardiac Arrest and Resuscitation
- Voice and Speech Disorders
- Cardiovascular Disease and Adiposity
- Cardiovascular and exercise physiology
Cidelec (France)
2023-2025
Institut de recherche en horticulture et semences
2025
École Supérieure d'Électronique de l'Ouest
2020-2023
Le Mans Université
2020-2023
Laboratoire d'Acoustique de l'Université du Mans
2020-2023
Centre National de la Recherche Scientifique
2020-2023
Université d'Angers
2021
Creusot-Loire Entreprises (France)
2009
Rationale: Randomized controlled trials showed no effect of positive airway pressure (PAP) therapy for obstructive sleep apnea (OSA) on cardiovascular (CV) risk. However, patient selection and low PAP adherence preclude the generalization their data to clinical samples. Objectives: To evaluate association between hours use, mortality, CV morbidity in real-life conditions. Methods: Data from Pays de la Loire Cohort were linked health administrative identify incident major adverse events...
It is currently unclear which patients with obstructive sleep apnea (OSA) are at increased cardiovascular risk.
Rationale: Data from population-based cohorts suggest that symptom subtypes and obstructive sleep apnea (OSA)-specific hypoxic burden (HB) could help to better identify patients with OSA at high cardiovascular (CV) risk. Objectives: We aimed evaluate whether those new markers are associated the risk of major adverse CV events (MACE) in clinical setting. Methods: Pays de la Loire cohort were linked health administrative data occurrence MACE (a composite outcome including all-cause mortality,...
Rationale: Nocturnal hypoxemia and sympathetic/parasympathetic imbalance might contribute to the occurrence or atrial fibrillation (AF) in patients with obstructive sleep apnea (OSA). During recordings, pulse rate variability (PRV) derived from oximetry provide an accurate estimation of heart variability, which reflects autonomic cardiovascular control. Objectives: We aimed evaluate whether indices oxygen desaturation PRV nocturnal were associated AF incidence investigated for OSA. Methods:...
To assess, in a large cohort of patients with obstructive sleep apnea, the factors that are independently associated positional apnea (POSA) and exclusive POSA (e-POSA) determine their prevalence. The secondary objective was to evaluate outcome positive airway pressure (PAP) therapy for e-POSA.This retrospective study included 6,437 typical mild-to-severe OSA from Pays de la Loire cohort. Patients e-POSA were compared those non-POSA clinical polysomnographic characteristics. In subgroup (n =...
Abstract Background The impact of Positive Airway Pressure (PAP) therapy on the use oral antihypertensive drugs (OAHDs) in patients with obstructive sleep apnoea (OSA) remains unclear. This study aimed to evaluate association between PAP and delivery OAHDs. Methods Data from Pays de la Loire Sleep Cohort were linked French health insurance database quantify OAHD hypertension at initiation therapy. primary endpoint was change score, reflecting number classes delivered. groups defined as:...
The pathophysiology of residual sleepiness in treated obstructive sleep apnoea (OSA) remains poorly understood. Animal models suggest that it may involve neuronal damage due to intermittent hypoxia and fragmentation. In a cohort 122 continuous positive airway pressure (CPAP) OSA patients referred for maintenance wakefulness test, we explored the determinants (objective) alertness those (subjective) assessed by Epworth Sleepiness Scale. We found logistic models, hypoxic burden was...
Sleep apnoea specific heart rate response (ΔHR) has been identified as a promising biomarker for stratifying cardiovascular (CV) risk, and predicting positive airway pressure (PAP) benefit in obstructive sleep (OSA). However, the need prior manual scoring of respiratory events potentially limits accessibility reproducibility ΔHR. We aimed to evaluate association pulse oxygen desaturations automatically derived from oximetry (ΔHRoxi) with CV risk OSA. ΔHRoxi ΔHR were measured OSA patients...
Increasing evidence links obstructive sleep apnea (OSA) to cognitive decline. Autonomic dysfunction assessed by heart rate variability is a promising early biomarker of impairment in populations without major neurocognitive disorder (MND). We aimed determine whether nocturnal pulse (PRV) extracted from oximetry signal and OSA severity could predict MND onset among older patients.This study relied on data collected within the multicenter longitudinal Pays de la Loire Sleep Cohort, linked...
Objective. Cardiovascular disease (CVD) is one of the leading causes death worldwide. There are many CVD risk estimators but very few take into account sleep features. Moreover, they rarely tested on patients investigated for obstructive apnea (OSA). However, numerous studies have demonstrated that OSA index or features associated with and mortality. The aim this study to propose a new simple mortality estimator use in routine testing.Approach. Data from large multicenter cohort CVD-free...
Previous studies have reported inconsistent findings regarding the association between obstructive sleep apnea (OSA) and incident venous thromboembolism (VTE). More specifically, OSA unprovoked VTE was barely evaluated. We aimed to evaluate whether hypopnea index (AHI) nocturnal hypoxemia markers were associated with incidence in patients investigated for OSA. Data from Pays de la Loire Sleep Cohort linked French health administrative data identify suspected no previous disease. Cox...
Cardiovascular (CV) disorders and obstructive sleep apnea (OSA) are very prevalent diseases worldwide. Multiple studies have demonstrated that OSA is associated with increased CV risk. Clinicians need to assess the risk select proper treatment. A growing number of research employed machine learning predict by integrating clinical features. In this paper, a multiple input deep model was proposed directly use signals combined Data from 5,506 patients Pays de la Loire Sleep Cohort, without...