A5072927942- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Sleep and related disorders
- Sleep and Wakefulness Research
- Cardiovascular and Diving-Related Complications
- Respiratory Support and Mechanisms
- Extracellular vesicles in disease
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular Syncope and Autonomic Disorders
- Cardiovascular Health and Disease Prevention
- High Altitude and Hypoxia
- Tracheal and airway disorders
- Adipose Tissue and Metabolism
- Non-Invasive Vital Sign Monitoring
- Heart Rate Variability and Autonomic Control
- Cardiovascular Disease and Adiposity
- Dysphagia Assessment and Management
- Liver Disease Diagnosis and Treatment
- Airway Management and Intubation Techniques
- Inflammatory Biomarkers in Disease Prognosis
- Thermoregulation and physiological responses
- Blood Pressure and Hypertension Studies
- Venous Thromboembolism Diagnosis and Management
- COVID-19 Clinical Research Studies
- Gastroesophageal reflux and treatments
Université d'Angers
2016-2025
Inserm
2016-2025
Centre Hospitalier Universitaire d'Angers
2016-2025
Centre National de la Recherche Scientifique
2008-2025
Laboratoire Stress Oxydant et Pathologies Métaboliques
2009-2021
SleepMed
2021
Université Bretagne Loire
2016-2020
Trialog (France)
2020
University of Chicago
2016-2017
Université Nantes Angers Le Mans
2012-2013
The aim of this study was to compare mandibular advancement device (MAd) therapy and continuous positive airway pressure (CPAP) for obstructive sleep apnoea/hypopnoea syndrome (OSAHS) after one-night polysomnographic (PSG) titration both treatments. 59 OSAHS patients (apnoea/hypopnoea index (AHI): 34+/-13 events x h(-1); Epworth scale: 10.6+/-4.5) were included in a crossover trial 8 weeks MAd CPAP effective titration. Outcome measurements home study, sleepiness, health-related quality life...
Rationale: Randomized controlled trials showed no effect of positive airway pressure (PAP) therapy for obstructive sleep apnea (OSA) on cardiovascular (CV) risk. However, patient selection and low PAP adherence preclude the generalization their data to clinical samples. Objectives: To evaluate association between hours use, mortality, CV morbidity in real-life conditions. Methods: Data from Pays de la Loire Cohort were linked health administrative identify incident major adverse events...
Abstract Background With the lack of effective therapy, chemoprevention, and vaccination against SARS-CoV-2, focusing on immediate repurposing existing drugs gives hope curbing COVID-19 pandemic. A recent unbiased genomics-guided tracing SARS-CoV-2 targets in human cells identified vitamin D among three top-scoring molecules manifesting potential infection mitigation patterns. Growing pre-clinical epidemiological observational data support this assumption. We hypothesized that...
Rationale: Data from population-based cohorts suggest that symptom subtypes and obstructive sleep apnea (OSA)-specific hypoxic burden (HB) could help to better identify patients with OSA at high cardiovascular (CV) risk. Objectives: We aimed evaluate whether those new markers are associated the risk of major adverse CV events (MACE) in clinical setting. Methods: Pays de la Loire cohort were linked health administrative data occurrence MACE (a composite outcome including all-cause mortality,...
The increasing number of patients requiring home noninvasive ventilation (HNIV) is a challenge for our healthcare system. Telemonitoring may be used to facilitate the management HNIV patients. We aimed assess ability telemonitoring algorithms identify not adequately ventilated. Our secondary aim was consequences related these algorithms, including costs. 11 experts each provided an algorithm with suboptimal ventilation. Each tested using real-life data from cohort over 90-day period....
Rationale: Nocturnal hypoxemia and sympathetic/parasympathetic imbalance might contribute to the occurrence or atrial fibrillation (AF) in patients with obstructive sleep apnea (OSA). During recordings, pulse rate variability (PRV) derived from oximetry provide an accurate estimation of heart variability, which reflects autonomic cardiovascular control. Objectives: We aimed evaluate whether indices oxygen desaturation PRV nocturnal were associated AF incidence investigated for OSA. Methods:...
Rationale: Endothelial dysfunction, a major predictor of late cardiovascular events, is linked to the severity obstructive sleep apnea (OSA).Objectives: To determine whether treatment with mandibular advancement device, main alternative continuous positive airway pressure, improves endothelial function in patients severe OSA.Methods: In this trial, we randomized OSA and no overt disease receive 2 months either effective device or sham device. The primary outcome, change reactive hyperemia...
Chronic sleep fragmentation (SF) increases cancer aggressiveness in mice. Exosomes exhibit pleiotropic biological functions, including immune regulatory antigen presentation, intracellular communication and inter-cellular transfer of RNA proteins. We hypothesized that SF-induced alterations biosynthesis cargo plasma exosomes may affect tumor cell properties.SF-derived increased proliferation (~13%), migration (~2.3-fold) extravasation (~10%) when compared to from SC-exposed Similarly, Pre...
ABSTRACT Background and objective Average volume‐assured pressure support—automated expiratory positive airway (AVAPS‐AE) combines an automated to maintain upper patency support with a targeted tidal volume. The aim of this study was compare the effects 2‐month AVAPS‐AE ventilation versus (ST) on sleep quality in stable patients OHS. Secondary outcomes included arterial blood gases, health‐related life, daytime sleepiness, subjective compliance NIV. Methods This is prospective multicentric...
Using signal processing measures we evaluate the effect of aging on peripheral cardiovascular system. Laser Doppler flowmetry (LDF) signals, reflecting microvascular perfusion, are recorded forearm 27 healthy subjects between 20-30, 40-50, or 60-70 years old. Wavelet-based representations, Hölder exponents, and sample entropy values computed for each time series. The results indicate a possible modification system with aging. Thus, endothelial-related metabolic activity decreases, but not...
To assess, in a large cohort of patients with obstructive sleep apnea, the factors that are independently associated positional apnea (POSA) and exclusive POSA (e-POSA) determine their prevalence. The secondary objective was to evaluate outcome positive airway pressure (PAP) therapy for e-POSA.This retrospective study included 6,437 typical mild-to-severe OSA from Pays de la Loire cohort. Patients e-POSA were compared those non-POSA clinical polysomnographic characteristics. In subgroup (n =...
Summary Previous studies have highlighted the pivotal role of emotional regulation impairment in progression depressive and insomnia disorders, individually. Nevertheless, to date, no study has undertaken a direct comparison profiles individuals experiencing with or without major episode (MDE). In this study, our objective was closely examine multiple aspects among insomnia, concurrent depression. This descriptive observational involved 57 participants, comprising 27 comorbid chronic MDE, 30...
Sleep apnoea specific heart rate response (ΔHR) has been identified as a promising biomarker for stratifying cardiovascular (CV) risk, and predicting positive airway pressure (PAP) benefit in obstructive sleep (OSA). However, the need prior manual scoring of respiratory events potentially limits accessibility reproducibility ΔHR. We aimed to evaluate association pulse oxygen desaturations automatically derived from oximetry (ΔHRoxi) with CV risk OSA. ΔHRoxi ΔHR were measured OSA patients...