A5046663017- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Sleep and Wakefulness Research
- Respiratory Support and Mechanisms
- Dysphagia Assessment and Management
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular Syncope and Autonomic Disorders
- Amyotrophic Lateral Sclerosis Research
- Sleep and related disorders
- Restless Legs Syndrome Research
- Scoliosis diagnosis and treatment
- Tracheal and airway disorders
- Neurogenetic and Muscular Disorders Research
- Cardiovascular and Diving-Related Complications
- Airway Management and Intubation Techniques
- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Spinal Cord Injury Research
- Orthodontics and Dentofacial Orthopedics
- Temporomandibular Joint Disorders
- Voice and Speech Disorders
- Spinal Fractures and Fixation Techniques
- Botulinum Toxin and Related Neurological Disorders
- Inhalation and Respiratory Drug Delivery
- Oral and gingival health research
Sorbonne Université
2015-2024
Assistance Publique – Hôpitaux de Paris
2015-2024
Inserm
2015-2024
Pitié-Salpêtrière Hospital
2015-2024
Institut de Biomécanique Humaine Georges Charpak
2017-2024
HESAM Université
2021-2024
École nationale supérieure d'arts et métiers
2018-2024
Université Sorbonne Paris Nord
2021-2024
ParisTech
2017-2024
Neurophysiologie respiratoire expérimentale et clinique
2014-2023
Rationale: Excessive daytime sleepiness is a common disabling symptom in obstructive sleep apnea syndrome.Objectives: To evaluate the efficacy and safety of pitolisant, selective histamine H3 receptor antagonist with wake-promoting effects, for treatment patients moderate to severe refusing continuous positive airway pressure treatment.Methods: In an international, multicenter, double-blind, randomized (3:1), placebo-controlled, parallel-design trial, pitolisant was individually titrated at...
There are only few data concerning persistence of neutralizing antibodies (NAbs) among SARS-CoV-2-infected healthcare workers (HCW). These individuals particularly exposed to SARS-CoV-2 infection and at potential risk reinfection. We followed 26 HCW with mild COVID-19 three weeks (D21), two months (M2) (M3) after the onset symptoms. All had anti-receptor binding domain (RBD) IgA D21, decreasing 38.5% M3 (p < 0.0001). Concomitantly a significant decrease in NAb titers was observed between D21...
In amyotrophic lateral sclerosis (ALS), the progressive loss of upper and lower motor neurons leads to respiratory failure, often with predominant diaphragm dysfunction, death. Because is only active inspiratory muscle during rapid eye movement (REM) sleep, there a high theoretical risk disorders REM sleep in patients ALS. To assess this hypothesis, we studied characteristics (polysomnography) 21 ALS, stratified according presence or absence diaphragmatic dysfunction. Diaphragmatic...
Background and aim Hypoglossal nerve stimulation (HNS) decreases obstructive sleep apnoea (OSA) severity via genioglossus muscle activation decreased upper airway collapsibility. This study assessed the safety effectiveness at 6 months post-implantation of a novel device delivering bilateral HNS small implanted electrode activated by unit worn externally, to treat OSA: Genio™ system. Methods prospective, open-label, non-randomised, single-arm treatment was conducted eight centres in three...
The characteristics of residual excessive sleepiness (RES), defined by an Epworth score >10 in adequately treated apnoeic patients, are unknown. 40 with (n = 20) and without RES, 20 healthy controls underwent clinical interviews, cognitive biological tests, polysomnography, a multiple sleep latency test, 24-h monitoring. marked subjective the RES group (mean± sd 16.4±3) contrasted moderately abnormal objective measures (90% patients had daytime latencies >8 min). Compared more fatigue,...
<h3>Introduction</h3> Non-invasive ventilation (NIV) is part of standard care in amyotrophic lateral sclerosis (ALS). Intolerance or unavailability NIV, as well the quality correction nocturnal hypoventilation, has a direct impact on prognosis. <h3>Objectives</h3> We describe importance NIV failure due to upper airway obstructive events, clinical characteristics, their prognosis ALS. <h3>Methods</h3> Retrospective analysis data 190 patients with ALS and single centre for period 2011–2014....
Amyotrophic lateral sclerosis (ALS) is a progressive disorder of unknown origin. Respiratory involvement the principal cause death, and dyspnoea major source discomfort. In this study, diaphragm function described its relationship with examined in 48 ALS patients (32 male, age 26-80 yrs). The detailed neurological respiratory evaluation (clinical examination, pulmonary tests, static pressures, mouth twitch pressures (Pm,t), electromyographic responses to phrenic nerve stimulation cortical...
Cervical magnetic stimulation (CMS), a nonvolitional test of diaphragm function, is an easy means for measuring the latency motor response to phrenic nerve stimulation, namely, conduction time (PNCT). In this application, CMS has some practical advantages over electrical in neck (ES). Although normal ES-PNCTs have been consistently reported between 7 and 8 ms, data are less homogeneous CMS-PNCTs, with reports suggesting lower values. This study systematically compares ES- CMS-PNCTs same...
To describe patients with sexsomnia and to contrast their clinical sleep measures those of healthy controls sleepwalkers.Subjects referred for sleepwalking/night terror were interviewed, completed the Paris Arousal Disorder Severity Scale (PADSS), monitored 1-2 nights video-polysomnography.Seventeen (70.6% male, aged 17-76 years) had sexsomnia, amnestic fondling bed partner (n = 11), complete sexual intercourse 8), masturbation spontaneous orgasm 1). The behaviors more direct during than...
Mandibular repositioning devices (MRDs) are usually recommended as the first therapy option in patients with mild-to-moderate obstructive sleep apnoea (OSA). However, data on long-term efficacy of MRDs limited, not only OSA who noncompliant continuous positive airway pressure (CPAP) but also those more severe OSA. The ORCADES study aimed to prospectively determine and tolerability two custom-made Narval™ for apnoea–hypopnoea syndrome (OSAHS) patients. interim 3- 6-month reported. Eligible...
ABSTRACT Background and objective Average volume‐assured pressure support—automated expiratory positive airway (AVAPS‐AE) combines an automated to maintain upper patency support with a targeted tidal volume. The aim of this study was compare the effects 2‐month AVAPS‐AE ventilation versus (ST) on sleep quality in stable patients OHS. Secondary outcomes included arterial blood gases, health‐related life, daytime sleepiness, subjective compliance NIV. Methods This is prospective multicentric...
There is a large body of data to support the use an inhaled corticosteroid (ICS) plus long‐acting β 2 ‐agonist vs. increasing dose ICS in adults, but less children. This double‐blind, parallel group, non‐inferiority study compared lung function and asthma control, based on Global Initiative for Asthma guidelines, children receiving either salmeterol/fluticasone propionate (SFC) 50/100 μg bd (n = 160) or fluticasone (FP) 200 161) 12 wks. Change from baseline mean morning peak expiratory flow...
Abstract Study Objectives Excessive sleepiness is a common symptom in Prader–Willi syndrome (PWS), and it negatively impacts the quality of life. Obstructive sleep apnea narcolepsy phenotypes have been reported PWS. We characterized disorders large cohort adults with Methods All consecutive patients genetically confirmed PWS unselected for sleep-related symptoms, underwent clinical interview, polysomnography, multiple latency tests (MSLT, n = 60), followed by long-term (24 hours)...
In obstructive sleep apnea (OSA), long-term adherence to treatment is crucial. This prospective single-center study investigated factors associated with mandibular repositioning device (MRD) therapy.All OSA patients who had MRD initiated in the previous year were prospectively contacted evaluate effectiveness and compliance. Long-term was based on continuation of (yes/no). Predictors analyzed using an adjusted multivariate analysis.Median follow-up 1002 days (interquartile range: 668-1345)...
Sleep-disordered breathing (SDB) is a common comorbidity in patients with heart failure (HF) and associated worse prognosis.
The twitch occlusion technique is a promising tool for use in accessing central drive to the diaphragm and determining maximal transdiaphragmatic pressure (Pdi) from submaximal efforts. It clinical limited by difficulties inherent bilateral electrical stimulation (BES) of phrenic nerves. This study was designed revisit using cervical magnetic (CMS). In addition, effects voluntary contraction on response cortex (CxMS) were studied. Seven volunteers aged 23-33 yrs Pdi determined at relaxed...
The obstructive sleep apnea syndrome (OSAS) involves recurrent sleep-related upper airways (UA) collapse. UA mechanical properties and neural control are altered, imposing a load on inspiration. collapse does not occur during wakefulness, hence arousal-dependent compensation. Experimental inspiratory loading in normal subjects elicits respiratory-related cortical activity. objective of this study was to test whether awake OSAS patients would exhibit similar Descriptive physiology study....