A5113683922- Respiratory Support and Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Obstructive Sleep Apnea Research
- Tracheal and airway disorders
- Dysphagia Assessment and Management
- Neurogenetic and Muscular Disorders Research
- Neuroscience of respiration and sleep
- Muscle Physiology and Disorders
- Intensive Care Unit Cognitive Disorders
- Airway Management and Intubation Techniques
- Long-Term Effects of COVID-19
- Myasthenia Gravis and Thymoma
- Lysosomal Storage Disorders Research
- Amyotrophic Lateral Sclerosis Research
- Cystic Fibrosis Research Advances
- Peripheral Neuropathies and Disorders
- Genetic Neurodegenerative Diseases
- Voice and Speech Disorders
- Glycogen Storage Diseases and Myoclonus
- Cardiac Arrest and Resuscitation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Spinal Cord Injury Research
- Mitochondrial Function and Pathology
- Parkinson's Disease Mechanisms and Treatments
- Adrenal Hormones and Disorders
Assistance Publique – Hôpitaux de Paris
2016-2025
Université Paris-Saclay
2021-2025
Université de Versailles Saint-Quentin-en-Yvelines
2016-2025
Hôpital Raymond-Poincaré
2016-2025
Inserm
2016-2025
Handicap neuromusculaire : Physiopathologie, Biothérapie et Pharmacologie appliquées
2019-2024
PHENIX laboratory
2022
Hôpitaux Universitaires Paris-Ouest
2013-2021
Physiol (Belgium)
2020
Centre de Référence des Maladies Autoinflammatoires et des Amyloses
2019
<b><i>Background:</i></b> Mechanical insufflation-exsufflation (MI-E), more commonly known as ‘cough assist therapy', is a method which produces inspiratory and expiratory assistance to improve cough performances. However, other alternatives or combinations are possible. <b><i>Objective:</i></b> The objective was compare the effects of mechanical insufflation combined with manually assisted coughing (MAC), alone MAC in neuromuscular patients...
To estimate the effect of prophylactic angiotensin-converting enzyme inhibitors (ACEi) on survival in Duchenne muscular dystrophy (DMD).We analysed data from French multicentre DMD Heart Registry (ClinicalTrials.gov: NCT03443115). We estimated association between prescription ACEi and event-free 668 patients aged 8 to 13 years, with normal left ventricular function, using (i) a Cox model intervention as time-dependent covariate, (ii) propensity-based analysis comparing treatment vs. no...
The tapering of prednisone therapy in generalized myasthenia gravis (MG) presents a therapeutic dilemma; however, the recommended regimen has not yet been validated.To compare efficacy standard slow-tapering with rapid-tapering regimen.From June 1, 2009, to July 31, 2013, multicenter, parallel, single-blind randomized trial was conducted 2 regimens tapering. Data analysis from February 18, 2019, January 23, 2020. A total 2291 adults confirmed diagnosis moderate severe MG at 7 specialized...
Background Type 2C and 2D limb girdle muscular dystrophies (LGMD) are a group of autosomal recessive manifested by proximal myopathy, impaired respiratory muscle function cardiomyopathy. The correlation the prognostic impact heart impairment poorly described. We aimed to describe long-term cardiac follow-up these patients determine predictive factors cardio-respiratory events mortality in LGMD 2D. Methods reviewed charts 34 patients, followed from 2005 2015, obtain echocardiographic, sleep...
Functional imaging studies in normal humans have shown that the supplementary motor area (SMA) and primary cortex (PMC) are coactivated during various breathing tasks. It is not known whether a direct pathway from SMA to diaphragm exists, if so what properties it has. Using transcranial magnetic stimulation (TMS) site at vertex, representing cortex, has been identified. TMS mapping revealed second 3 cm anterior vertex overlying SMA, which had rapidly conducting (mean latency 16.7 +/- 2.4...
<h3>BACKGROUND:</h3> Pulse oximetry alone has been suggested to determine which patients on home mechanical ventilation (MV) require further investigation of nocturnal gas exchange. In with neuromuscular diseases, alveolar hypoventilation (AH) is rarely accompanied ventilation-perfusion ratio heterogeneity, and, therefore, may be less sensitive for detecting AH than in lung disease. <h3>OBJECTIVE:</h3> To whether pulse (S<sub>pO<sub>2</sub></sub>) and transcutaneous carbon dioxide...
Restrictive respiratory failure is a major cause of morbidity and mortality in neuromuscular diseases (NMD). Home mechanical ventilation (HMV) used to treat hypoventilation, its efficiency mostly assessed by daytime blood gases or nocturnal oxygen saturation monitoring (SpO2). Non-invasive transcutaneous measure CO2 (TcCO2) allows directly assess hypercapnia detect residual hypoventilation with higher sensitivity than SpO2. We aimed compare the prognostic value SpO2 TcCO2 ventilated adult...
Background In patients with neuromuscular disorders, assessment of respiratory function relies on forced vital capacity (FVC) measurements. Providing complementary outcomes may be useful for clinical trials. Diaphragm sniff ultrasound (US) is a noninvasive technique that can assess diaphragm affected in disorders. Purpose We aimed to provide normal values ultrasound, the relationship between US, (VC) and nasal pressure. Additionally, we evaluate diagnostic accuracy US predicting restrictive...