A5020719351- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Adrenal Hormones and Disorders
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Renal function and acid-base balance
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- Tracheal and airway disorders
- SARS-CoV-2 and COVID-19 Research
- Pneumonia and Respiratory Infections
- Anesthesia and Sedative Agents
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- EEG and Brain-Computer Interfaces
- Hemodynamic Monitoring and Therapy
- Epilepsy research and treatment
- Heme Oxygenase-1 and Carbon Monoxide
- Voice and Speech Disorders
- Peripheral Neuropathies and Disorders
- Immune Response and Inflammation
- Thermal Regulation in Medicine
- Cardiac, Anesthesia and Surgical Outcomes
- Pharmacological Effects and Toxicity Studies
- Nosocomial Infections in ICU
Hôpital Raymond-Poincaré
2015-2024
Assistance Publique – Hôpitaux de Paris
2015-2024
Université Paris-Saclay
2018-2024
Université de Versailles Saint-Quentin-en-Yvelines
2018-2024
Inserm
2015-2024
Infection et inflammation
2017-2024
Hôpital Antoine-Béclère
2023
Institut thématique Immunologie, inflammation, infectiologie et microbiologie
2020-2022
Weatherford College
2020
Délégation Paris 7
2010-2019
Coronavirus disease 2019 (COVID-19) is associated with severe lung damage. Corticosteroids are a possible therapeutic option.
Early diagnosis of coronavirus disease 2019 (COVID-19) is the utmost importance but remains challenging. The objective current study was to characterize exhaled breath from mechanically ventilated adults with COVID-19. In this prospective observational study, we used real-time, online, proton transfer reaction time-of-flight mass spectrometry perform a metabolomic analysis expired air undergoing invasive mechanical ventilation in intensive care unit due severe COVID-19 or non-COVID-19 acute...
<h2>Abstract</h2><h3>Background</h3> Complement pathway inhibition may provide benefit for severe acute respiratory illnesses caused by viral infections such as COVID-19. We present results from a nonrandomized proof-of-concept study of complement C5 inhibitor eculizumab treatment <h3>Methods</h3> All patients (<i>N</i> = 80) with confirmed SARS-CoV-2 infection and COVID-19 admitted to our intensive care unit between March 10 May 5, 2020 were included. Forty-five treated standard 35 plus...
Abstract Background Severe acute respiratory syndrome coronavirus-2 (SARS–CoV-2)-induced distress (ARDS) causes high mortality. Umbilical cord-derived mesenchymal stromal cells (UC-MSCs) have potentially relevant immune-modulatory properties, whose place in ARDS treatment is not established. This phase 2b trial was undertaken to assess the efficacy of UC-MSCs patients with SARS–CoV-2-induced ARDS. Methods multicentre, double-blind, randomized, placebo-controlled (STROMA–CoV-2) recruited...
Sepsis is associated with increased mortality, delirium and long-term cognitive impairment in intensive care unit (ICU) patients. Electroencephalogram (EEG) abnormalities occurring at the acute stage of sepsis may correlate severity brain dysfunction. Predictive value early standard EEG for mortality ICU septic patients remains to be assessed.In this prospective, single center, observational study, was performed, analyzed classified according both Synek Young scales, consecutive acutely...
Abstract Infection with SARS-CoV-2 variant Omicron is considered to be less severe than infection Delta, rarer occurrence of disease requiring intensive care. Little information available on comorbid factors, clinical conditions and specific viral mutational patterns associated the severity infection. In this multicenter prospective cohort study, patients consecutively admitted for COVID-19 in 20 care units France between December 7th 2021 May 1st 2022 were included. Among 259 patients, we...
Severe Pneumocystis jirovecii pneumonia (PJP) requiring intensive care has been the subject of few prospective studies. It is unclear whether delayed curative antibiotic therapy may impact survival in these severe forms PJP. The corticosteroid combined with antibiotics also unclear.
Given the high risk of thrombosis and anticoagulation-related bleeding in patients with hypoxemic COVID-19 pneumonia, identifying lowest effective dose anticoagulation therapy for these is imperative.To determine whether therapeutic (TA) or high-dose prophylactic (HD-PA) decreases mortality and/or disease duration compared standard-dose (SD-PA), TA outperforms HD-PA; to compare net clinical outcomes among 3 strategies.The ANTICOVID randomized open-label trial included pneumonia requiring...
Acetazolamide has been used for decades as a respiratory stimulant patients with chronic obstructive pulmonary disease (COPD) and metabolic alkalosis, but no large randomized placebo-controlled trial is available to confirm this approach.To determine whether acetazolamide reduces mechanical ventilation duration in critically ill COPD alkalosis.The DIABOLO study, randomized, double-blind, multicenter trial, was conducted from October 2011 through July 2014 15 intensive care units (ICUs)...
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes disease 2019 (COVID-19) through excessive end organ inflammation. Despite improved understanding of the pathophysiology, management, and great efforts worldwide to produce effective drugs, death rates COVID-19 patients remain unacceptably high, treatment is unfortunately lacking. Pharmacological strategies aimed at modulating inflammation in are being evaluated worldwide. Several drug therapies targeting this...
We describe a retrospective review of 38 cases reconstruction following resection the metaphysiodiaphysis lower limb for malignant bone tumours using free vascularised fibular grafts. The mean follow-up was 7.6 years (0.4 to 18.4). Musculoskeletal Tumor Society score 27.2 (20 30). significantly higher when graft carried out in one-stage procedure after tumour rather than two stages. Bony union achieved 89% cases. overall time 1.7 (0.2 10.3). Free transfer is major operation with frequent,...