A5039023548- Inflammation biomarkers and pathways
- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- Nosocomial Infections in ICU
- Apelin-related biomedical research
- COVID-19 Clinical Research Studies
- Immune Response and Inflammation
- Cardiac Arrest and Resuscitation
- Pneumonia and Respiratory Infections
- Neonatal and Maternal Infections
- Public Health and Nutrition
- Long-Term Effects of COVID-19
- Methodologies in Health Research and Practice
- SARS-CoV-2 and COVID-19 Research
- Kawasaki Disease and Coronary Complications
- Hemodynamic Monitoring and Therapy
- Mesenchymal stem cell research
- Sports and Physical Education Research
- Vitamin C and Antioxidants Research
- Advanced Glycation End Products research
- Heart Failure Treatment and Management
- Family and Patient Care in Intensive Care Units
- Renal function and acid-base balance
- Antibiotic Resistance in Bacteria
Centre Hospitalier Régional et Universitaire de Nancy
2015-2024
Université de Lorraine
2014-2024
Imation (United States)
2006-2024
Assistance Publique – Hôpitaux de Paris
2004-2024
National and Kapodistrian University of Athens
2024
Evangelismos Hospital
2024
Hôpital Saint-Louis
2024
Inserm
2012-2023
Université de Lille
2023
Défaillance Cardiovasculaire Aiguë et Chronique
2014-2021
The diagnosis and treatment of bacterial pneumonia in patients who are receiving mechanical ventilation remain a difficult challenge. triggering receptor expressed on myeloid cells (TREM-1) is member the immunoglobulin superfamily, its expression phagocytes specifically up-regulated by microbial products. presence soluble TREM-1 (sTREM-1) bronchoalveolar-lavage fluid from may be an indicator pneumonia.
Background: Previous experimental studies have suggested that the triggering receptor expressed on myeloid cells-1 (TREM-1) is specifically upregulated in presence of microbial products. Objective: To evaluate diagnostic value plasma levels soluble form TREM-1 patients admitted with clinical suspicion infection. Design: Prospective, noninterventional study conducted between July and September 2003. Setting: Medical adult intensive care unit at a university hospital France. Participants: 76...
Although the outcome of sepsis benefits from prompt administration appropriate antibiotics on correct diagnosis, assessment infection in critically ill patients is often a challenge for clinicians. In this setting, simple biomarkers, especially when used combination, could prove useful.To determine usefulness combination biomarkers to diagnose sepsis.Three hundred consecutive were enrolled construct biologic score that was next validated an independent prospective cohort 79 another...
Whether the antiinflammatory and immunomodulatory effects of glucocorticoids may decrease mortality among patients with severe community-acquired pneumonia is unclear.In this phase 3, multicenter, double-blind, randomized, controlled trial, we assigned adults who had been admitted to intensive care unit (ICU) for receive intravenous hydrocortisone (200 mg daily either 4 or 7 days as determined by clinical improvement, followed tapering a total 8 14 days) placebo. All received standard...
Ilofotase alfa is a human recombinant alkaline phosphatase with reno-protective effects that showed improved survival and reduced Major Adverse Kidney Events by 90 days (MAKE90) in sepsis-associated acute kidney injury (SA-AKI) patients. REVIVAL, was phase-3 trial conducted to confirm its efficacy safety. In this international double-blinded randomized-controlled trial, SA-AKI patients were enrolled < 72 h on vasopressor 24 of AKI. The primary endpoint 28-day all-cause mortality. main...
The triggering receptor expressed on myeloid cells (TREM)-1 is a recently discovered the surface of neutrophils and subset monocytes. Engagement TREM-1 has been reported to trigger synthesis proinflammatory cytokines in presence microbial products. Previously, we have identified soluble form (sTREM-1) observed significant levels serum samples from septic shock patients but not controls. Here, investigated its putative role modulation inflammation during sepsis. We that sTREM-1 was secreted...
Objective: To describe the course of plasma sTREM (soluble triggering receptor expressed on myeloid cells)-1, procalcitonin (PCT), and C-reactive protein (CRP) concentrations during sepsis their clinical informative value in predicting outcome. Design: Prospective, noninterventional study. Setting: Medical adult intensive care unit at a university hospital France. Patients: Sixty-three critically ill patients with sepsis, severe or septic shock. Interventions: None. Measurements Main...
During septic shock, muscle produces lactate by way of an exaggerated NaK-adenosine triphosphatase (ATPase)-stimulated aerobic glycolysis associated with epinephrine stimulation possibly through beta2 adrenoreceptor involvement. It therefore seems logical that a proportion hyperlactatemia in low cardiac output states would be also related to this mechanism. Thus, low-flow and normal-to-high-flow models we investigate (1) whether (2) production is linked adrenergic Na+K+-ATPase. We locally...
Metformin-associated lactic acidosis (MALA) is a classic side effect of metformin and known to be severe disease with high mortality rate. The treatment MALA dialysis controversial the subject many case reports in literature. We aimed assess prevalence 16-bed, university-affiliated, intensive care unit (ICU), on patient outcome.Over five-year period, we retrospectively identified all patients who were either admitted ICU as usual medication, or attempted suicide by ingestion. Within this...
Rationale: Optimal outcome after myocardial infarction (MI) depends on a coordinated healing response in which both debris removal and repair of the extracellular matrix play major role. However, adverse remodeling excessive inflammation can promote heart failure, positioning leucocytes as central protagonists potential therapeutic targets tissue wound MI. Objective: In this study, we examined role triggering receptor expressed myeloid cells-1(TREM-1) orchestrating inflammatory that follows...
Primary objective was to identify leukocyte subsets that could predict the early evolution of sepsis at 48 hours (i.e., deterioration or stability/improvement). Secondary objectives were evaluate prognostic value on mortality and immunosuppressive properties immature granulocytes.Twenty-three peripheral blood analyzed using a new-generation 10-color flow cytometry. T-cell killing activity granulocytes explored sorting method specifically developed.ICUs emergency departments.All patients...
Abstract During sepsis, neutrophil activation induces endothelial cell (EC) dysfunction partly through extracellular trap (NET) release. The triggering receptor expressed on myeloid cell-1 (TREM-1) is an orphan immune that amplifies the inflammatory response mediated by Toll-like receptor-4 (TLR4) engagement. Although key role of TLR4 signaling in NETosis known, TREM-1 this process has not yet been investigated. Here, we report potentiates NET release human and murine neutrophils a component...
Abstract Background Ventilator-associated pneumonia caused by Pseudomonas aeruginosa (PA) in hospitalised patients is associated with high mortality. The effectiveness of the bivalent, bispecific mAb MEDI3902 (gremubamab) preventing PA nosocomial was assessed PA-colonised mechanically ventilated subjects. Methods EVADE (NCT02696902) a phase 2, randomised, parallel-group, double-blind, placebo-controlled study Europe, Turkey, Israel, and USA. Subjects ≥ 18 years old, ventilated, tracheally...
Objective Genetic differences in immune responses may affect susceptibility to and outcome of septic shock. CD14 seems be an important part the innate system, initiating antimicrobial response. We evaluated frequency a recently discovered promoter gene polymorphism (C T transition at base pair −159) among patients with shock compared those control group. Design Multiple-center study. Setting Hospital research department. Patients Ninety consecutive white were included. The group consisted...
Abstract Triggering receptor expressed on myeloid cells-1 (TREM-1) is a recently identified molecule involved in the amplification of inflammation. To determine regulation TREM-1, we studied TREM-1 expression and soluble plasma levels upon i.v. LPS challenge healthy humans vivo vitro. Granulocyte was high at baseline immediately down-regulated exposure along with an increase TREM-1. Monocytes displayed gradual up-regulation In vitro studies extended these findings to highly purified...