A5081876737- Cardiac Valve Diseases and Treatments
- Respiratory Support and Mechanisms
- Cardiac Imaging and Diagnostics
- Nosocomial Infections in ICU
- Cardiovascular Function and Risk Factors
- Aortic Disease and Treatment Approaches
- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- Ultrasound in Clinical Applications
- Pneumonia and Respiratory Infections
- Infective Endocarditis Diagnosis and Management
- Intensive Care Unit Cognitive Disorders
- Pulmonary Hypertension Research and Treatments
- Cardiomyopathy and Myosin Studies
- Sepsis Diagnosis and Treatment
- Tracheal and airway disorders
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrest and Resuscitation
- Inhalation and Respiratory Drug Delivery
- Airway Management and Intubation Techniques
- Antibiotic Resistance in Bacteria
- Cardiac pacing and defibrillation studies
- Antibiotics Pharmacokinetics and Efficacy
- Cardiac Structural Anomalies and Repair
- Radiation Dose and Imaging
Hôpital Nord
2024
Centre Hospitalier Universitaire de Limoges
2011-2021
Hospital Clínic de Barcelona
2019
Universitat de Barcelona
2019
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2019
Hôpital Universitaire Dupuytren
2008-2019
Inserm
2011-2017
Hôpital Dupuytren
2008-2017
Assistance Publique – Hôpitaux de Paris
2017
Sorbonne Université
2017
Previous trials involving patients with the acute respiratory distress syndrome (ARDS) have failed to show a beneficial effect of prone positioning during mechanical ventilatory support on outcomes. We evaluated early application outcomes in severe ARDS.In this multicenter, prospective, randomized, controlled trial, we randomly assigned 466 ARDS undergo prone-positioning sessions at least 16 hours or be left supine position. Severe was defined as ratio partial pressure arterial oxygen...
Many patients with severe acute respiratory distress syndrome (ARDS) caused by influenza A(H1N1) infection receive extracorporeal membrane oxygenation (ECMO) as a rescue therapy.To analyze factors associated death in ECMO-treated and the influence of ECMO on intensive care unit (ICU) mortality.Data from admitted for H1N1-associated ARDS to French ICUs were prospectively collected 2009 2011 through national REVA registry. We analyzed in-ICU recipients, potential benefit using propensity...
Reignier, Jean*†; Mercier, Emmanuelle‡; Le Gouge, Amelie§; Boulain, Thierry║; Desachy, Arnaud¶; Bellec, Frederic#; Clavel, Marc**; Frat, Jean-Pierre††; Plantefeve, Gaetan‡‡; Quenot, Jean-Pierre§§; Lascarrou, Jean-Baptiste* For the Clinical Research in Intensive Care and Sepsis Group Author Information
To assess the ability of ultrasonography to identify presence and volume pleural effusion in intensive care unit setting.Prospective descriptive clinical study.Medical-surgical a teaching hospital.Initial study group (group I) consisted 97 patients (mean [+/-SD] Simplified Acute Physiology Score II, 40 +/- 14) with clinically suspected effusion. Fifty-one were mechanically ventilated 55 underwent unilateral or bilateral thoracentesis (58 procedures). All supine chest radiography at bedside....
The aim of this study was to compare a 7-day course doripenem 10-day imipenem-cilastatin for ventilator-associated pneumonia (VAP) due Gram-negative bacteria.This prospective, double-blinded, randomized trial comparing fixed one gram as four-hour infusion every eight hours with one-hour (April 2008 through June 2011).The stopped prematurely at the recommendation Independent Data Monitoring Committee that blinded treatment arm assignment and performed scheduled review data which showed...
Aminoglycosides aerosolization might achieve better diffusion into the alveolar compartment than intravenous use. The objective of this multicenter study was to evaluate aerosol-delivered amikacin penetration epithelial lining fluid (ELF) using a new vibrating mesh nebulizer (Pulmonary Drug Delivery System (PDDS), Nektar Therapeutics), which delivers high doses lungs.Nebulized (400 mg bid) delivered lungs 28 mechanically ventilated patients with Gram-negative VAP for 7-14 days, adjunctive...
Non-invasive evaluation of left ventricular filling pressure has been scarcely studied in critically ill patients. Accordingly, we prospectively assessed the ability transoesophageal echocardiography (TEE) Doppler to predict an invasive pulmonary artery occlusion (PAOP) < or = 18 mmHg ventilated patients.During two consecutive 3-year periods, TEE parameters were compared right heart catheterisation derived PAOP used as reference 88 patients, haemodynamically stable and sinus rhythm (age: 63...
The role of herpes simplex virus (HSV) reactivation on morbidity and mortality in patients the intensive care unit requiring mechanical ventilation remains unknown.To determine whether preemptive treatment with intravenous acyclovir reduces duration HSV oropharyngeal reactivation.A double-blind, placebo-controlled randomized clinical trial was conducted 16 units France. Participants included 239 adults (age, >18 years) who received for at least 96 hours continued to receive 48 or more,...
Acetazolamide has been used for decades as a respiratory stimulant patients with chronic obstructive pulmonary disease (COPD) and metabolic alkalosis, but no large randomized placebo-controlled trial is available to confirm this approach.To determine whether acetazolamide reduces mechanical ventilation duration in critically ill COPD alkalosis.The DIABOLO study, randomized, double-blind, multicenter trial, was conducted from October 2011 through July 2014 15 intensive care units (ICUs)...
Patient-ventilator asynchrony is associated with a poorer outcome. The prevalence and severity of during the early phase weaning has never been specifically described. authors' first aim was to evaluate prognosis impact factors asynchrony. Their second compare according two methods detection: visual inspection signals computerized method integrating electromyographic activity diaphragm.This an ancillary study multicenter, randomized controlled trial comparing neurally adjusted ventilatory...
Assessment of cardiac function is key in the management intensive care unit (ICU) patients and frequently relies on use standard transthoracic echocardiography (TTE). A commercially available new generation ultrasound system with two-dimensional imaging capability, which has roughly size a mobile phone, adequately suited to extend physical examination. The primary endpoint this study was evaluate additional value miniaturized device used as an ultrasonic stethoscope (US) for determination...
Abstract: This report involves a 54‐year‐old man who died following refractory ventricular fibrillation after ingestion of plant in suicide attempt. Repeated direct‐current cardioversions were unsuccessful and no single anti‐arrhythmic agent was effective for arrhythmia control. The routine blood toxicological screening negative. Aconitine, the main toxin Aconitum napellus identified using specific liquid chromatography‐tandem mass spectrometry (LC‐MS/MS) method. whole concentration (24...