A5018825983- Cardiac Arrest and Resuscitation
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Acute Myocardial Infarction Research
- Healthcare Systems and Challenges
- COVID-19 Clinical Research Studies
- Mechanical Circulatory Support Devices
- Diversity and Career in Medicine
- Long-Term Effects of COVID-19
- Sepsis Diagnosis and Treatment
- Cardiac Imaging and Diagnostics
- Palliative Care and End-of-Life Issues
- Herpesvirus Infections and Treatments
- Healthcare cost, quality, practices
- Respiratory viral infections research
- Heart Failure Treatment and Management
- Pneumonia and Respiratory Infections
- Survey Methodology and Nonresponse
- Cardiac, Anesthesia and Surgical Outcomes
- Hospital Admissions and Outcomes
- Focus Groups and Qualitative Methods
- SARS-CoV-2 detection and testing
- Social and Intergroup Psychology
- Clinical Nutrition and Gastroenterology
- Nosocomial Infections in ICU
Hôpital Européen Georges-Pompidou
2014-2024
Assistance Publique – Hôpitaux de Paris
2019-2024
Université Paris Cité
2014-2024
University of Mannheim
2024
Heidelberg University
2024
Société de Réanimation de Langue Française
2024
Sorbonne Paris Cité
2024
Columbia University
2018-2022
Hôpital Européen
2019-2021
Columbia University Irving Medical Center
2020
Coronavirus disease-2019 (COVID-19), a respiratory disease has been associated with ischemic complications, coagulation disorders, and an endotheliitis. To explore endothelial damage activation-related biomarkers in COVID-19 patients criteria of hospitalization for referral to intensive care unit (ICU) and/or worsening. Analysis angiogenic soluble markers plasma from at admission. Study enrolled 40 consecutive admitted emergency department that fulfilled hospitalization. Half them were...
Nasopharyngeal swab is the reference sampling method to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as recommended by World Health Organization (WHO) (1). However, nasal specimens may have a slightly lower sensitivity than nasopharyngeal (2, 3). We herein validated an alternative procedure collect secretions with routinely used in medical bacteriology for which there no risk of supply disruption order perform molecular diagnosis SARS-CoV-2 infection.
<h3>Importance</h3> Although an emergency coronary angiogram (CAG) is recommended for patients who experience out-of-hospital cardiac arrest (OHCA) with ST-segment elevation on the postresuscitation electrocardiogram (ECG), this strategy still debated in without elevation. <h3>Objective</h3> To assess 180-day survival rate Cerebral Performance Category (CPC) 1 or 2 of OHCA ECG and undergo CAG vs delayed CAG. <h3>Design, Setting, Participants</h3> The Emergency Delayed Coronary Angiogram...
Abstract Rationale COVID-19 ARDS could differ from typical forms of the syndrome. Objective Pulmonary microvascular injury and thrombosis are increasingly reported as constitutive features respiratory failure. Our aim was to study pulmonary mechanics gas exchanges in COVID-2019 patients studied early after initiating protective invasive mechanical ventilation, seeking corresponding pathophysiological biological characteristics. Methods Between March 22 30, 2020 mechanics, exchanges,...
The role of herpes simplex virus (HSV) reactivation on morbidity and mortality in patients the intensive care unit requiring mechanical ventilation remains unknown.To determine whether preemptive treatment with intravenous acyclovir reduces duration HSV oropharyngeal reactivation.A double-blind, placebo-controlled randomized clinical trial was conducted 16 units France. Participants included 239 adults (age, >18 years) who received for at least 96 hours continued to receive 48 or more,...
As the population ages and cancer therapies improve, there is an increased call for elderly patients to be admitted intensive care unit (ICU). This study aimed assess short-term survival prognostic factors in critically ill with solid tumors aged ≥65 years. We conducted a retrospective study. The primary endpoint was ICU mortality. Resumption of anticancer therapy who survived stay 90-day mortality were secondary endpoints. All years Georges Pompidou Hospital (Paris, France) between 2009...
Cardiogenic shock (CS) is the most severe form of acute heart failure. Discrepancies have been reported between sexes regarding delays, pathways and invasive strategies in CS complicating myocardial infarction. However, effect sex on prognosis unselected remains controversial.
Critically ill patients display a state of immunosuppression that has been attributed in part to decreased plasma arginine concentrations. However, we and other authors have failed demonstrate clinical benefit L-arginine supplementation. We hypothesize that, these critically patients, low levels may be secondary the presence granulocytic myeloid-derived suppressor cells (gMDSC), which express arginase known convert into nitric oxide (NO) citrulline. Indeed, series 28 non-surgical showed...
Abstract Background The STROMA-CoV-2 study was a French phase 2b, multicenter, double-blind, randomized, placebo-controlled clinical trial that did not identify significant efficacy of umbilical cord-derived mesenchymal stromal cells in patients with SARS-CoV-2-induced acute respiratory distress syndrome. Safety on day 28 found to be good. aim our extended assess the 6- and 12-month safety UC-MSCs administration cohort. Methods A detailed multi-domain assessment conducted at 6 12 months...
Abstract Background The medical workforce has been feminized for the last two decades worldwide. Nonetheless, women remain under-represented among intensivists. We conducted a survey French intensivists to assess their professional and personal quality of life perception potential gender discrimination at work. Methods an observational descriptive study by sending survey, designed group FEMMIR (FEmmes Médecins en Médecine Intensive Réanimation), in France, using primarily Société de...
Describe the prevalence of acute cerebral dysfunction and assess prognostic value an early clinical electroencephalography (EEG) assessment in ICU COVID-19 patients.Prospective observational study.Two tertiary critical care units Paris, France, between April December 2020.Adult critically ill patients with respiratory distress syndrome.Neurologic examination EEG at two time points during stay, first under sedation second 4-7 days after discontinuation.Association abnormalities (background...
The decision for withholding and withdrawing of life-sustaining treatments (LSTs) in COVID-19 patients is currently based on a collegial mainly clinical assessment. In the context global pandemic overwhelmed health system, question LST support using prognostic biomarkers arises.In multicenter study 24 French hospitals, 2878 hospitalized medical departments from 26 February to 20 April 2020 were included. propensity-matched population, we compared clinical, biological, management...
Background: The role of herpes simplex virus (HSV) reactivation on morbidity/mortality in intensive care unit patients requiring mechanical ventilation remains controversial.Methods: In this multicentre study, non-immunosuppressed adults >18 years old, mechanically ventilated for at least 96 hours and expected to remain ≥48 hours, with HSV oropharyngeal reactivation, were double-blindly randomized receive intravenous acyclovir (5 mg/kg tid, 14 days) or a matching placebo (controls)....
Les réanimateurs sont régulièrement amenés à donner des avis en dehors de leur service. Deux circonstances distinctes l’origine ces consultations et les enjeux éthiques très différents. Dans le premier cas il s’agit d’évaluer l’état clinique d’un patient avec une défaillance d’organe ou risque dégradation. C’est alors expertise technique qui est demandée, comme pour tout autre spécialiste d’organe. la deuxième circonstance, demande discussion limitation et/ou d’arrêt traitement. Qu’il...
Pulmonary intravascular thrombus formation has been widely observed in patients with respiratory failure, for example, SARS-CoV-2 infection (COVID-19). The aim of this study was to evaluate the efficacy/safety alteplase thrombolysis COVID-19 severe hypoxemic failure. In multicenter, open-label study, were randomized receive (low- or high-dose) over 5 days plus standard care (SOC), SOC alone. primary endpoint time clinical improvement (≥ 2-point decrease on WHO Clinical Progression Scale,...
Prolonged stays in ICU have been associated with overconsumption of resources but little is known about their epidemiology. We aimed to identify predictors and prognostic factors extended stays, studying a long-stay population.We present retrospective cohort study between July 2000 December 2013 comparing patients hospitalized medical for ≥30 days (long-stay patients-LSP) <30 (short-stay patients-SSP). Admission characteristics were collected from the local database every patient evolution...
Despite advances in asthma treatments, severe exacerbation (SAE) remains a life-threatening condition adults, and there is lack of data derived from adult patients admitted to intensive care units (ICUs) for SAE. The current study investigated changes patient characteristics, management, outcomes SAE over 20-year period 40 ICUs the greater Paris area. In this retrospective observational study, admissions area January 1, 1997, December 31, 2016 were analyzed. primary outcome was proportion...
Introduction: In adults, the most common cause of out-of-hospital cardiac arrests (OHCA) is coronary artery disease. If an immediate angiogram (CAG) recommended for survivors presenting a ST segment elevation (ST +) on electrocardiogram (ECG) performed after resuscitation, there still debate regarding best strategy in patients without +. Hypothesis: Performing CAG OHCA + post-resuscitation ECG and no obvious non-cardiac arrest leads to better outcome. Methods: The EMERGE trial multicenter,...