Alexandre Gaudet
A5000486822- Inflammation biomarkers and pathways
- Respiratory Support and Mechanisms
- COVID-19 Clinical Research Studies
- Pancreatitis Pathology and Treatment
- Sepsis Diagnosis and Treatment
- Nosocomial Infections in ICU
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Apelin-related biomedical research
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Diabetes and associated disorders
- Pneumonia and Respiratory Infections
- Neonatal Respiratory Health Research
- Mechanical Circulatory Support Devices
- Cardiovascular Health and Disease Prevention
- Non-Invasive Vital Sign Monitoring
- Thermal Regulation in Medicine
- Hemodynamic Monitoring and Therapy
- Chronic Kidney Disease and Diabetes
- Ion Transport and Channel Regulation
- Heart Failure Treatment and Management
- Ultrasound in Clinical Applications
- Anesthesia and Neurotoxicity Research
- Healthcare Decision-Making and Restraints
Université de Lille
2017-2024
Centre Hospitalier Universitaire de Lille
2017-2024
Center for Infection and Immunity of Lille
2017-2024
Institut Pasteur de Lille
2017-2024
Centre National de la Recherche Scientifique
2017-2024
Inserm
2017-2024
Stanford University
2021-2024
Hôpital Roger Salengro
2017-2024
Centre Hospitalier de Béthune
2023
Unité de Glycobiologie Structurale et Fonctionnelle
2022
Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/mL, in plasma diluted 1 to 10) of IFN-α and/or -ω are found about 10% patients with critical COVID-19 pneumonia, but not subjects asymptomatic infections. We detect auto-Abs 100-fold lower, more physiological, (100 pg/mL, 1/10 dilutions plasma) 13.6% 3,595 COVID-19, including 21% 374 > 80 years, and 6.5% 522 severe COVID-19. These antibodies also detected 18% the 1,124 deceased (aged 20 days-99 years; mean: 70...
Significance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It important to estimate their quantitative impact on mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence these risk death increase with higher in men. Using an unvaccinated sample 1,261 deceased patients 34,159 individuals from general population, we found against IFNs strongly increased...
Recent multicenter studies identified COVID-19 as a risk factor for invasive pulmonary aspergillosis (IPA). However, no large study has compared the incidence of IPA between and influenza patients.To determine putative in critically ill SARS-CoV-2 patients, with patients.This was planned ancillary analysis coVAPid retrospective European cohort. Consecutive adult patients requiring mechanical ventilation > 48 h pneumonia or were included. The 28-day cumulative IPA, based on Blot definition,...
Prone positioning (PP) reduces mortality of patients with acute respiratory distress syndrome (ARDS). The potential benefit prone maneuvers during venovenous extracorporeal membrane oxygenation (ECMO) is unknown. aim this study was to evaluate the association between use support and ICU in a pooled population from previous European cohort studies.We performed individual patient data analysis studies which compared treated ECMO (Prone group) "conventional" management (Supine severe ARDS.889...
Abstract Background Baricitinib has shown efficacy in hospitalized patients with COVID-19, but no placebo-controlled trials have focused specifically on severe/critical COVID, including vaccinated participants. Methods Bari-SolidAct is a phase-3, multicentre, randomised, double-blind, trial, enrolling participants from June 3, 2021 to March 7, 2022, stopped prematurely for external evidence. Patients COVID-19 were randomised 4 mg once daily or placebo, added standard of care. The primary...
La polymerase chain reaction (PCR) est une technique de biologie moléculaire d’importance fondamentale qui permet détecter et quantifier des fragments spécifiques d’acides nucléiques. En combinant plusieurs primers dans même réaction, il possible manière simultanée cibles moléculaires distinctes, ce défi nit la PCR multiplex (mPCR). L’application plus fréquente en réanimation concerne le diagnostic syndromique infections, rendu par outils diagnostiques multicibles permettent détection...
Abstract Background Differentiating Ventilator-Associated Tracheobronchitis (VAT) from Pneumonia (VAP) may be challenging for clinicians, yet their management currently differs. In this study, we evaluated the accuracy of Clinical Pulmonary Infection Score (CPIS) to differentiate VAT and VAP. Methods We performed a retrospective analysis based on data 2 independent prospective cohorts. Patients TAVeM database with diagnosis ( n = 320) or VAP 369) were included in derivation cohort. admitted...
Acute respiratory distress syndrome is a severe form of failure, occurring in up to 20% patients admitted the intensive care unit with sepsis. Dysregulated leukocyte diapedesis major contributor acute syndrome. Endocan circulating proteoglycan that binds integrin functional antigen-1 and blocks its interaction endothelial ligand, ICAM-1. The objective this study was evaluate role endocan control lung inflammation. In vitro, inhibited human transendothelial migration as well ICAM-1-dependent...
Abstract Dysregulated leukocyte diapedesis is a major contributor to acute severe inflammatory states like sepsis and respiratory distress syndrome, which are common conditions in critically ill subjects. Endocan circulating proteoglycan that binds the integrin LFA-1 blocks its interaction with endothelial ligand ICAM-1, subsequently leading inhibition of recruitment. Recent data have highlighted hypothetic role p14, endocan's catabolite found bloodstream septic patients, as potential...
Survivors after acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19) are at high risk of developing sequelae and functional impairment. The healthcare crisis caused by the pandemic hit socially disadvantaged populations. We aimed evaluate influence socio-economic status on COVID-19 ARDS. carried out a prospective multicenter study in 30 French intensive care units (ICUs), where ARDS survivors were pre-enrolled if they fulfilled Berlin criteria. For patients...
We aimed to compare the outcomes of patients under veno-venous extracorporeal membrane oxygenation (V-V ECMO) for COVID-19-Acute Respiratory Distress Syndrome (CARDS) between first and second wave. From 1 March 2020 30 November 2020, fifty requiring a V-V ECMO support CARDS were included. Patient demographics, pre-ECMO, day one, three, seven on-ECMO data collected. The 90-day mortality was 11% higher during wave (18/26 (69%)) compared (14/24 (58%) (p = 0.423). During wave, all given steroids...
Esm-1 is primarily expressed in glomerular endothelium humans. Cells expressing Esm1 exhibit a high degree of conservation the enrichment genes related to blood vessel development. In context diabetes, these cells are reduced number and show significant transcriptional shift toward chemotaxis pathway. there polarization glomerulus that reflected by deficiency.
Predictive scores assessing the risk of respiratory failure in COVID-19 mostly focused on prediction early intubation. A combined assessment clinical parameters and biomarkers endotheliopathy could allow to predict late worsening acute (ARF), subsequently warranting intubation COVID-19. Retrospective single-center derivation (n = 92 subjects) validation cohorts 59 subjects), including severe patients with non-invasive support, were assessed for at least 48 h following intensive care unit...
Background: Acute respiratory distress syndrome (ARDS) is a life-threatening condition resulting from acute pulmonary inflammation. However, no specific treatment for ARDS has yet been developed. Previous findings suggest that lung injuries related to could be regulated by endocan (Esm-1). The aim of this study was evaluate the potential efficiency in ARDS. Methods: We first compared features inflammation and severity hypoxemia tracheal LPS-induced injury (ALI) model performed knockout...