Jean‐Christophe Lagier
A5044290242- Genomics and Phylogenetic Studies
- Bacterial Identification and Susceptibility Testing
- Gut microbiota and health
- COVID-19 Clinical Research Studies
- Clostridium difficile and Clostridium perfringens research
- SARS-CoV-2 and COVID-19 Research
- Probiotics and Fermented Foods
- Whipple's Disease and Interleukins
- Long-Term Effects of COVID-19
- Plant Pathogens and Fungal Diseases
- Mycobacterium research and diagnosis
- Bacteriophages and microbial interactions
- Microbial Community Ecology and Physiology
- SARS-CoV-2 detection and testing
- Infective Endocarditis Diagnosis and Management
- Respiratory viral infections research
- Streptococcal Infections and Treatments
- Diphtheria, Corynebacterium, and Tetanus
- COVID-19 epidemiological studies
- Microscopic Colitis
- Identification and Quantification in Food
- Viral gastroenteritis research and epidemiology
- Pneumonia and Respiratory Infections
- Microbial Metabolism and Applications
- Diabetes and associated disorders
Méditerranée Infection Foundation
2016-2025
Assistance Publique Hôpitaux de Marseille
2016-2025
Aix-Marseille Université
2016-2025
Institut de Recherche pour le Développement
2016-2025
Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes
2012-2024
Inserm
2012-2024
Centre National de la Recherche Scientifique
2011-2024
Institut de Microbiologie de la Méditerranée
2022-2023
Université Côte d'Azur
2022
Centre Hospitalier Universitaire de Nice
2010-2022
Abstract Background Chloroquine and hydroxychloroquine have been found to be efficient on SARS-CoV-2, reported in Chinese COV-19 patients. We evaluate the role of respiratory viral loads. Patients methods were included a single arm protocol receive 600mg daily their load nasal swabs was tested daily. Depending clinical presentation, azithromycin added treatment. Untreated patients from another center cases refusing as negative controls. Presence absence virus at Day6-post inclusion...
Abstract Metagenomics revolutionized the understanding of relations among human microbiome, health and diseases, but generated a countless number sequences that have not been assigned to known microorganism 1 . The pure culture prokaryotes, neglected in recent decades, remains essential elucidating role these organisms 2 We recently introduced microbial culturomics, culturing approach uses multiple conditions matrix-assisted laser desorption/ionization–time flight 16S rRNA for identification...
Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/mL, in plasma diluted 1 to 10) of IFN-α and/or -ω are found about 10% patients with critical COVID-19 pneumonia, but not subjects asymptomatic infections. We detect auto-Abs 100-fold lower, more physiological, (100 pg/mL, 1/10 dilutions plasma) 13.6% 3,595 COVID-19, including 21% 374 > 80 years, and 6.5% 522 severe COVID-19. These antibodies also detected 18% the 1,124 deceased (aged 20 days-99 years; mean: 70...
During the past 5 years, matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry (MS) has become a powerful tool for routine identification in many clinical laboratories. We analyzed our 11-year experience isolates (40 months using MALDI-TOF MS and 91 conventional phenotypic [CPI]). Among 286,842 clonal isolates, 284,899 459 species were identified. The remaining 1,951 misidentified required confirmation second 670 molecular technique 1,273 339 species....
In our institute in Marseille, France, we initiated early and massive screening for coronavirus disease 2019 (COVID-19). Hospitalization treatment with hydroxychloroquine azithromycin (HCQ-AZ) was proposed the positive cases.
The gut microbiota is an ecosystem including all bacterial species that permanently colonize the gastro intestinal tract and a large number of other microorganisms from environment. These millions may be unbalanced by external internal factors. aim this review to summarize recent findings on animal human studies effect dietary geographical provenance microbiota-composition. It includes results influence products, type diet (e.g. vegetarian omnivorous subgroups), geographic areas, as well...
Severe acute malnutrition (SAM) is associated with inadequate diet, low levels of plasma antioxidants and gut microbiota alterations. The link between redox microbial alterations, however, remains unexplored. By sequencing the microbiomes 79 children varying nutritional status from three centers in Senegal Niger, we found a dramatic depletion obligate anaerobes malnutrition. This was confirmed an individual patient data meta-analysis including 107 cases 77 controls 5 different African Asian...
Significance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It important to estimate their quantitative impact on mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence these risk death increase with higher in men. Using an unvaccinated sample 1,261 deceased patients 34,159 individuals from general population, we found against IFNs strongly increased...
Culture of Tropheryma whipplei, the agent Whipple disease (WD), was achieved in our laboratory 2000, allowing new perspectives for diagnosis this and description other potential clinical manifestations caused by microorganism. Since we have developed tools center Marseille, France, to optimize T whipplei infections. Classic WD characterized positive periodic acid-Schiff performed on duodenal biopsy. In absence histologic involvement, localized infections were defined specific polymerase...